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HRK

  • Official Full Name

    harakiri, BCL2 interacting protein (contains only BH3 domain)

  • Overview

    Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL
  • Synonyms

    HRK; DP5; HARAKIRI; harakiri, BCL2 interacting protein (contains only BH3 domain); activator of apoptosis hara-kiri; activator of apoptosis Hrk; Neuronal death protein DP5; BCL2-interacting protein; BH3-interacting domain-containing protein 3; death protein 5; harakiri, BCL2-interacting protein (contains only BH3 domain); BID3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HRK-645H Recombinant Human HRK Mammalian Cell His
Human HRK-3114H Recombinant Human HRK, GST-tagged E.Coli or Yeast GST 91
Human HRK-5039H Recombinant Human HRK Protein, GST-tagged Wheat Germ GST
Human HRK-5391HCL Recombinant Human HRK 293 Cell Lysate HEK293 N/A
Human HRK-3124H Recombinant Human HRK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HRK-3670HF Recombinant Full Length Human HRK Protein, GST-tagged In Vitro Cell Free System GST 91 amino acids
Human HRK-3124H-B Recombinant Human HRK Protein Pre-coupled Magnetic Beads HEK293
Rat HRK-2914R Recombinant Rat HRK Protein Mammalian Cell His
Rat HRK-2569R Recombinant Rat HRK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HRK-2569R-B Recombinant Rat HRK Protein Pre-coupled Magnetic Beads HEK293
Bovine Hrk-3115B Recombinant Bovine Hrk, GST-tagged E.Coli or Yeast GST 92
Homo sapiens (Human) RFL3129HF Recombinant Full Length Human Activator Of Apoptosis Harakiri(Hrk) Protein, His-Tagged E.coli expression system His Full Length (1-91)
Mus musculus (Mouse) RFL33284MF Recombinant Full Length Mouse Activator Of Apoptosis Harakiri(Hrk) Protein, His-Tagged E.coli expression system His Full Length (1-92)
Rattus norvegicus (Rat) RFL7252RF Recombinant Full Length Rat Activator Of Apoptosis Harakiri(Hrk) Protein, His-Tagged E.coli expression system His Full Length (1-92)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HRK Related Articles
  • HRK Related Research Area

HRK involved in several pathways and played different roles in them. We selected most pathways HRK participated on our site, such as ATF-2 transcription factor network, Apoptosis, Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ATF-2 transcription factor networkHRK;DUSP5;GADD45A;POU2F1;DDIT3;MAPK14;CBFB;JDP2;CSRP2
ApoptosisDIABLO;PANK1A;IRAK4;CAPN2B;JUN;DBNLB;APAF1;IKBKG;Gzmg
Apoptosis Modulation and SignalingDIABLO;SEPT4;CDKN2A;DAXX;HN1;BCL2L11;BIK;BLK;BAG3

HRK has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HRK itself. We selected most functions HRK had, and list some proteins which have the same functions with HRK. You can find most of the proteins on our site.

Function Related Protein
protein bindingUPRT;MZB1;RAI1;ELK1;MCM10;PRDX6;RPS6KA5;ROCK2A;DDC

HRK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRK here. Most of them are supplied by our site. Hope this information will be useful for your research of HRK.

BCL2L1; C1QBP; Bcl2a1; BCL2L1; BCL2L2; Bcl2l1; C1QBP; MCL1

Jurisicova, A; Antenos, M; et al. Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation. MOLECULAR HUMAN REPRODUCTION 9:133-141(2003).
Sanz, C; Horita, M; et al. Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells. HAEMATOLOGICA 87:903-907(2002).
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