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HSD17B6

  • Official Full Name

    hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)

  • Overview

    NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone.
  • Synonyms

    HSD17B6; hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); HSE; RODH; SDR9C6; 17-beta-hydroxysteroid dehydrogenase type 6; 17-beta-HSD6; 17-beta-HSD 6; oxidoreductase; 3-alpha->beta-HSE; retinol dehydrogenase; 3-hydroxysteroid epimerase; 3-alpha->beta-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; oxidative 3-alpha hydroxysteroid dehydrogenase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; short chain dehydrogenase/reductase family 9C, member 6; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSD17B6-13961H Recombinant Human HSD17B6, GST-tagged E.coli GST 1-317a.a.
Human HSD17B6-5072H Recombinant Human HSD17B6 Protein, GST-tagged Wheat Germ GST
Human HSD17B6-5372HCL Recombinant Human HSD17B6 293 Cell Lysate HEK293 N/A
Human HSD17B6-3703H Recombinant Human HSD17B6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HSD17B6-3872HF Recombinant Full Length Human HSD17B6 Protein, GST-tagged In Vitro Cell Free System GST 317 amino acids
Human HSD17B6-01H Recombinant Human 3-alpha(17-beta)-hydroxysteroid dehydrogenase protein, His-tagged E.coli His 307
Human HSD17B6-1107H-B Recombinant Human HSD17B6 Protein Pre-coupled Magnetic Beads HEK293
Human HSD17B6-1703HFL Recombinant Full Length Human HSD17B6 Protein, C-Flag-tagged Mammalian cells Flag
Human HSD17B6-1107H Recombinant Human HSD17B6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HSD17B6-7880M Recombinant Mouse HSD17B6 Protein Mammalian Cell His
Mouse Hsd17b6-3444M Recombinant Mouse Hsd17b6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HSD17B6-4337M-B Recombinant Mouse HSD17B6 Protein Pre-coupled Magnetic Beads HEK293
Mouse HSD17B6-4337M Recombinant Mouse HSD17B6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSD17B6-2929R Recombinant Rat HSD17B6 Protein Mammalian Cell His
Rat HSD17B6-2584R Recombinant Rat HSD17B6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HSD17B6-2584R-B Recombinant Rat HSD17B6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HSD17B6-2156R Recombinant Rhesus monkey HSD17B6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HSD17B6-1977R-B Recombinant Rhesus Macaque HSD17B6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HSD17B6-1977R Recombinant Rhesus Macaque HSD17B6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSD17B6 Related Articles

HSD17B6 involved in several pathways and played different roles in them. We selected most pathways HSD17B6 participated on our site, such as Steroid hormone biosynthesis, Retinol metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Steroid hormone biosynthesisCOMTA;CYP19A1A;CYP2C70;HSD11B2;HSD11B1;STS;CYP2D26;UGT2A1;UGT1A6
Retinol metabolismRETSATL;CYP2C50;CYP26C1;CYP3A7;SDR16C5;DHRS3;CYP2C70;UGT1A7C;HSD17B6
Metabolic pathwaysGALCB;UGT1AB;UCK2A;SDHC;SPTLC2;NDUFA5;SCP2A;MTR;ybaS

HSD17B6 has several biochemical functions, for example, catalytic activity, electron carrier activity, estradiol 17-beta-dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B6 itself. We selected most functions HSD17B6 had, and list some proteins which have the same functions with HSD17B6. You can find most of the proteins on our site.

Function Related Protein
catalytic activityPARP3;PPM1NB;PPM1AB;PPM1BB;ACSM2;OLFM4;CWF19L2;CKMB;PNP6
electron carrier activityACAD9;AKR7A2;HAAO;NDUFS6;IVD;POR;ADH5;SDHD;NDUFS2
estradiol 17-beta-dehydrogenase activityH2-KE6;HSD17B12B;HSD17B12A;HSD17B14;HSD17B11;RDH8;HSD17B10;HSD17B8;HSD17B12
oxidoreductase activityAKR7A5;QDPRB2;DMGDH;CYP2P7;CYP19A1B;P4HA1A;DPYDB;RFESD;CYP21A1
retinol dehydrogenase activityRDH12;HSD17B6;RDH5;ADH1;SDR9C7;RDH7;ADH4;ADH7;AKR1C3
testosterone dehydrogenase (NAD+) activityH2-KE6;HSD17B8;HSD17B1;AKR1C3;HSD17B2;DHRS9;HSD17B6

HSD17B6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B6.

Ju, R; Wu, W; et al. Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:227-233(2015).
Al-Bader, M; Kilarkaje, N; et al. Effects of bleomycin, etoposide and cisplatin treatment on Leydig cell structure and transcription of steroidogenic enzymes in rat testis. EUROPEAN JOURNAL OF PHARMACOLOGY 747:150-159(2015).
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