Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

HYOU1

Official Full Name

hypoxia up-regulated 1
Overview

The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription;start sites. A cis-acting segment found in the 5 UTR is involved in stress-dependent induction, resulting in the;accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this;gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein;is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in;hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast;tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation;site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is;only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the;cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by;an amino-terminal targeting signal.
Synonyms

HYOU1; hypoxia up-regulated 1; hypoxia up-regulated protein 1; glucose regulated protein 170; Grp170; HSP12A; ORP150; glucose-regulated protein 170; 150 kDa oxygen-regulated protein; oxygen regulated protein (150kD); 170 kDa glucose-regulated protein; GRP; GRP-170; ORP-150;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Human Cell
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

C
10×His
GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HYOU1-3255H	Recombinant Human HYOU1 protein, His-tagged	HEK293	His	Met695-Leu994	Inquiry
Human	HYOU1-30518TH	Recombinant Human HYOU1, His-tagged	E.coli	His		Inquiry
Human	HYOU1-2295HCL	Recombinant Human HYOU1 cell lysate	Human Cell	N/A		Inquiry
Human	HYOU1-5215H	Recombinant Human HYOU1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HYOU1-2742H	Recombinant Human HYOU1 Protein (Met695-Leu999), C-10×His tagged	Mammalian cells	C-10×His	Met695-Leu999	Inquiry
Human	HYOU1-5744HF	Recombinant Full Length Human HYOU1 Protein, GST-tagged	In Vitro Cell Free System	GST	36-147 amino acids	Inquiry
Human	HYOU1-2743H	Recombinant Human HYOU1 Protein (Met695-Leu994), N-His tagged	E.coli	N-His	Met695-Leu994	Inquiry
Mouse	HYOU1-7961M	Recombinant Mouse HYOU1 Protein	Mammalian Cell	His		Inquiry
Mouse	HYOU1-4395M	Recombinant Mouse HYOU1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	HYOU1-4395M-B	Recombinant Mouse HYOU1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	HYOU1-11978Z	Recombinant Zebrafish HYOU1	Mammalian Cell	His		Inquiry
Chicken	HYOU1-1725C	Recombinant Chicken HYOU1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

HYOU1 involved in several pathways and played different roles in them. We selected most pathways HYOU1 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, IRE1alpha activates chaperones, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYOU1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Binding and Uptake of Ligands by Scavenger Receptors	COL1A2;APOBB.1;HP;HPX;SPARC;CD163;Alb;IGLC2;SAA1
IRE1alpha activates chaperones	FKBP14;DNAJB9;CXXC1;PDIA6;HYOU1;ASNA1;SERP1;DDX11;ADD1
Metabolism of proteins	ADAMTS3;ADAMTSL1;MPDU1;EEF1D;RNF2;F9A;IGFBP6;KIFC3;COX17
Protein processing in endoplasmic reticulum	SEC62;UBE2G1B;CAPN1;GSBP9;UBE2D1B;CKAP4;DERL1;CAPN2L;HSPA5
Scavenging by Class F Receptors	HYOU1;HSPH1
Unfolded Protein Response (UPR)	DNAJB9;TPP1;SEC63;HYOU1;C19orf10;YY2;CXXC1;KLHDC3;YIF1A
Vesicle-mediated transport	RALAA;BLOC1S1;MYO6B;CLINT1;BLOC1S6;TRAPPC3;PLDN;SEC16B;CX30.3
XBP1(S) activates chaperone genes	TPP1;YIF1A;DNAJB9;PDIA6;DDX11;WIPI1;SERP1;KDELR3;FKBP14

HYOU1 has several biochemical functions, for example, ATP binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HYOU1 itself. We selected most functions HYOU1 had, and list some proteins which have the same functions with HYOU1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MYH15;KIF3C;MKNK1;AK3;MAPKAPK2;TGFBR1;ABCA5;STK35L;UBE2KA
chaperone binding	SERPINA7;PRNP;DNAJA1;ERP29;CXorf41;GET4;STIP1;SDF2L1;DNAJB7

HYOU1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYOU1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYOU1.

SGK1; MCC; HLA-A; HLA-A; VHL; ARF6; IKBKE; EXT2; TNFRSF10D; TRAF6; ere_dna; cona_canen; ESR1; GBA; env; Itgb1; HSPA5; H2AFX; NSS