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HSPA1B

Official Full Name

heat shock 70kDa protein 1B
Overview

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
Synonyms

HSPA1B; heat shock 70kDa protein 1B; heat shock 70kD protein 1B; heat shock 70 kDa protein 1A/1B; HSP70 2; HSP70-1/HSP70-2; HSP70.1/HSP70.2; heat shock 70 kDa protein 1/2; HSPA1A; HSP70-2; HSP70-1B; FLJ54328;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Cattle
Human
Mouse

Source

E. coli
E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

C
His
GST
His (Fc)
Avi
SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HSPA1B-5102H	Recombinant Human HSPA1B Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HSPA1B-29401TH	Recombinant Human HSPA1B		N/A		Inquiry
Human	HSPA1B-28995TH	Recombinant Human HSPA1B	E.coli	N/A		Inquiry
Human	HSPA1B-29397TH	Recombinant Human HSPA1B	E.coli	N/A		Inquiry
Human	HSPA1B-29402TH	Recombinant Human HSPA1B	E.coli	N/A		Inquiry
Human	HSPA1B-29395TH	Recombinant Human HSPA1B, His-tagged	E.coli	His		Inquiry
Human	HSPA1B-29399TH	Recombinant Human HSPA1B, His-tagged		His		Inquiry
Human	HSPA1B-2623H	Recombinant Human HSPA1B protein(381-610 aa), C-His-tagged	E. coli	C-His	381-610 aa	Inquiry
Mouse	HSPA1B-7905M	Recombinant Mouse HSPA1B Protein	Mammalian Cell	His		Inquiry
Mouse	Hspa1b-403M	Recombinant Mouse Hspa1b Protein, His-tagged	E.coli	His	Met1~Asp642	Inquiry
Mouse	HSPA1B-4355M	Recombinant Mouse HSPA1B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	HSPA1B-4355M-B	Recombinant Mouse HSPA1B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Hspa1b-3057M	Recombinant Mouse Hspa1b protein, His-SUMO-tagged	E.coli	His-SUMO	2-642aa	Inquiry
Cattle	HSPA1B-402C	Recombinant Cattle HSPA1B Protein, His-tagged	E.coli	His	Met1~Asp641	Inquiry

Involved Pathway
Protein Function
Interacting Protein
HSPA1B Related Articles

HSPA1B involved in several pathways and played different roles in them. We selected most pathways HSPA1B participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Spliceosome	SF3A1;PCBP1;LSM2;PRPF38B;SNRPD1;CRNKL1;PHF5A;TRA2B;LSM8
MAPK signaling pathway	RPS6KA6;MAPT;PLA2G4D;PLA2G4AA;RELA;AKT1;FGF22;NTF3;FGF3
Protein processing in endoplasmic reticulum	CKAP4;PRKCSH;MAN1A1;CRYABA;UBE2E1;YOD1;NFE2L2A;HYOU1;HNF4B
Endocytosis	SH3GLB2;CXCR4B;SH3GLB2B;WAS;CCDC53;HRAS;HLA-B;PIP5KL1;KDR
Antigen processing and presentation	HSPA1L;IFI30;HLA-DRB4;HLA-DRA;KLRC3;H2-AA;CD8B1;KIR2DS5;NFYA
Estrogen signaling pathway	MMP2;PIK3R1;PIK3R2;SRC;GNAI3;SP1;CREB5;KRAS;ATF6B
Legionellosis	RAB1A;BNIP3;TLR5;CYCS;PYCARD;CASP9;ITGAM;NAIP6;HSPA6
Toxoplasmosis	HLA-DRB3;HLA-DRB1;CASP9;HLA-DOB;PIK3R3;IKBKG;HLA-DMB;IL12B;BCL2L1
Measles	TNFRSF10C;CD3D;IFNA5;PIK3R2;RAB9B;HSPA6;TBK1;EIF2AK4;MX1
Influenza A	ICAM1;MAPK11;MAP2K2;DNAJB1;Ifna15;IFNA8;MAP2K6;MAP2K4;BMA1
Epstein-Barr virus infection	POLR3F;GTF2E2;MAPK8;POLR3K;GSK3B;AKT2;PRKACB;NFKBIB;SFPI1

HSPA1B has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1B itself. We selected most functions HSPA1B had, and list some proteins which have the same functions with HSPA1B. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ABCG3;DGKAA;HNRNPU;KIF25;ERCC3;MCM8;MAT1A;ULK1;TGFBR1A
ATPase activity	HSPA8;ABCA1B;ABCG2A;KIF13B;ABCD1;INO80;KIF1B;DNA2;ATAD1A
ATPase activity, coupled	HSPA1B;HSPA6;PEX1;ABCB1A;MYO1E;MYH3;HSP104;CCT8;NSF
C3HC4-type RING finger domain binding	DNAJA1;HSPA1B;PINK1;HSPA1A;KCNH2;HSPA8
G-protein coupled receptor binding	RLN3;PACRG;POMC;PARK2;GNA13A;QRFP;SAA1;UCN2;PROK1
enzyme binding	EGLN1;FOXO4;NOS1;WWOX;SUPT5H;TBP;TULP3;SLPI;PRKCA
heat shock protein binding	LMAN2;PACRG;DNAJA2L;IRAK1;DNAJC7;PDXP;DNAJA3B;CDC37L1;PPID
protein binding	ADAM22;UHMK1;WNT3;SGOL2;NR2C2AP;GALR1;FXR2;DAO;FASLG
protein binding involved in protein folding	PFDN1;HSPA1B;DNAJB8;PDCL3;CALR3;CD74;CLGN;HSPA1A;RIC3
receptor binding	CSK;CCL13;LRRC4B;GIPC1;HMGCL;SNX17;ADCYAP1;F2;CAV1
ubiquitin protein ligase binding	AICDA;DERL1;AMBRA1;SQSTM1;RPA3;KDM4A;RAD18;MFN2;GPI1
unfolded protein binding	AFG3L2;ERLEC1;CALR3B;TOR1A;TCP1;CCT3;SYVN1;DNAJB5;CCT2
virus receptor activity	CD4;HSPA1B;EFNB3;LAMP1;MOG;CD209A;DPP4;SERPINB3;SLC10A1

HSPA1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1B.

EGFR; STUB1; SNCA; HSP90AA1

Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).

Lenna, S; Townsend, DM; et al. HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells. JOURNAL OF IMMUNOLOGY 184:4654-4661(2010).