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IDH3A

  • Official Full Name

    isocitrate dehydrogenase 3 (NAD+) alpha

  • Overview

    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong;to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five;isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the;mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other;predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated;rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha;subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one;isozyme of NAD(+)-dependent isocitrate dehydrogenase.
  • Synonyms

    IDH3A; isocitrate dehydrogenase 3 (NAD+) alpha; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; H IDH alpha; isocitrate dehydrogenase (NAD+) alpha chain; isocitrate dehydrogenase [NAD] subunit alpha; mitochondrial; isocitric dehydrogenase; NAD(H) specific isocitrate dehydrogenase alpha subunit; NAD+ specific ICDH; EC 1.1.1.41; HIDH alpha; IDH3A_HUMAN; Isocitrate dehydrogenase (NAD+) alpha chain precursor; Isocitrate dehydrogenase [NAD] subunit alpha mitochondrial; Isocitrate dehydrogenase; Isocitric dehydrogenase subunit alpha; NAD; NAD(+)-specific ICDH subunit alpha; NAD(H) specific isocitrate dehydrogenase alpha subunit precursor; NADsubunit alpha mitochondrial precursor; OTTHUMP00000184906; H-IDH alpha; NAD+-specific ICDH; NAD(H)-specific isocitrate dehydrogenase alpha subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IDH3A-28925TH Recombinant Human IDH3A Wheat Germ N/A 366 amino acids
Human IDH3A-5305HCL Recombinant Human IDH3A 293 Cell Lysate HEK293 N/A
Human IDH3A-1136H Recombinant Human IDH3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IDH3A-1136H-B Recombinant Human IDH3A Protein Pre-coupled Magnetic Beads HEK293
Human IDH3A-2376H Recombinant Human IDH3A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IDH3A-251HF Recombinant Full Length Human IDH3A Protein In Vitro Cell Free System 366 amino acids
Human IDH3A-1349HFL Recombinant Full Length Human IDH3A Protein, C-Flag-tagged Mammalian cells Flag
Mouse IDH3A-7986M Recombinant Mouse IDH3A Protein Mammalian Cell His
Mouse IDH3A-4411M Recombinant Mouse IDH3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IDH3A-4411M-B Recombinant Mouse IDH3A Protein Pre-coupled Magnetic Beads HEK293
Mouse Idh3a-3473M Recombinant Mouse Idh3a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat IDH3A-2987R Recombinant Rat IDH3A Protein Mammalian Cell His
Rat IDH3A-2642R Recombinant Rat IDH3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IDH3A-2642R-B Recombinant Rat IDH3A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IDH3A-2193R Recombinant Rhesus monkey IDH3A Protein, His-tagged Mammalian Cell His
Rhesus Macaque IDH3A-2014R Recombinant Rhesus Macaque IDH3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IDH3A-2014R-B Recombinant Rhesus Macaque IDH3A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IDH3A-11188Z Recombinant Zebrafish IDH3A Mammalian Cell His
Chicken IDH3A-1255C Recombinant Chicken IDH3A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IDH3A Related Articles

IDH3A involved in several pathways and played different roles in them. We selected most pathways IDH3A participated on our site, such as Citrate cycle (TCA cycle), Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Citrate cycle (TCA cycle)SUCLG2;SDHDB;DLDH;DLD;ACO2;SDHDA;PC;ACLYA;MDH2
Metabolic pathwaysMECR;LDHAL6A;HSD17B12A;AOX1;PAFAH1B1A;CRYL1;NFS1;NDST3;HDC
Carbon metabolismHIBCH;GLUD1B;FBP1;ENO3;TPI1;PFKM;OGDH;SUCLG2;ALDOAA
-Oxocarboxylic acid metabolismIDH1;IDH2;IDH3B;GOT2;ACO2;IDH3A;BCAT1;AADAT;IDH3G
Biosynthesis of amino acidsGLULB;PHGDH;ALDOC;BCAT2;MAT2AA;SDS;PRPS1L1;GM5506;ALDH7A1

IDH3A has several biochemical functions, for example, NAD binding, isocitrate dehydrogenase (NAD+) activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH3A itself. We selected most functions IDH3A had, and list some proteins which have the same functions with IDH3A. You can find most of the proteins on our site.

Function Related Protein
NAD bindingHIBADH;MDH1;CTBP2A;CTBP2L;ADH4;AOX1;GRHPRA;GPD1C;HPGD
isocitrate dehydrogenase (NAD+) activityIDH3B;IDH3G;IDH3A
magnesium ion bindingPRTFDC1;ENO1A;ITPK1;RPS6KA6;RNASEH1;ENO1;COMT;FARS2;MAPK12

IDH3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH3A here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH3A.

IDH3B; IDH3G; adp; DMWD; DDA1; IKBKG; RAB4A; glgA; MBNL1; MYC; gag-pol

Chen, XH; Wei, P; et al. A Novel Carbonyl Reductase with Anti-Prelog Stereospecificity from Acetobacter sp CCTCC M209061: Purification and Characterization. PLOS ONE 9:-(2014).
Yang, C; Fan, J; et al. The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit alpha in AFB(1) induced liver lesion. TOXICOLOGY LETTERS 224:371-379(2014).
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