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IDH3B

  • Official Full Name

    isocitrate dehydrogenase 3 (NAD+) beta

  • Overview

    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. NADP-specific isocitrate dehydrogenase (ICDH).
  • Synonyms

    IDH3B; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; mitochondrial; FLJ11043; H-IDHB; IDH3B_HUMAN; Isocitrate dehydrogenase [NAD] subunit beta; isocitrate dehydrogenase 3, beta subunit; Isocitric dehydrogenase; Isocitric dehydrogenase subunit beta; MGC903; NAD(+)-specific ICDH; NAD(+)-specific ICDH subunit beta; NAD+-specific isocitrate dehydrogenase b subunit; NAD+-specific isocitrate dehydrogenase beta; OTTHUMP00000030023; OTTHUMP00000030024; RP46; NAD+-specific ICDH; isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, beta subunit; Isocitrate Dehydrogenase (NADP +); Isocitrate Dehydrogenase; IDP; PICD; IDH; IDCD; IDPC; EC 1.1.1.42; Isocitrate dehydrogenase [NADP] cytoplasmic; Cytosolic NADP-isocitrate dehydrogenase; Oxalosuccinate decarboxylase; NADP(+)-specific ICDH; NADP+-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrog enase, peroxisomal; isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase (NADP+); isocitrate dehydrogenase (NADP); oxalsuccinic decarboxylase; isocitrate (NADP) dehydrogenase; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase; NADP-specific isocitrate dehydrogenase; NADP-linked isocitrate dehydrogenase; NADP-dependent isocitrate dehydrogenase; NADP isocitric dehydrogenase; isocitrate dehydrogenase (NADP-dependent); NADP-dependent isocitric dehydrogenase; triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase; NADP+-linked isocitrate dehydrogenase; IDH (ambiguous); dual-cofactor-specific isocitrate dehydrogenase; IDP1; IDP2; IDP3; isocitrate: NADP+ oxidoreductase (decarboxylating);

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Pig
  • Rat
  • Rhesus Macaque
  • S.cerevisiae
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Porcine Heart
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IDH3B-5304HCL Recombinant Human IDH3B 293 Cell Lysate HEK293 N/A
Human IDH3B-566H Recombinant Human IDH3B Protein (35-385 aa), GST-tagged E.coli GST 35-385 aa
Rat IDH3B-2988R Recombinant Rat IDH3B Protein Mammalian Cell His
Rat IDH3B-2643R-B Recombinant Rat IDH3B Protein Pre-coupled Magnetic Beads HEK293
Rat IDH3B-2643R Recombinant Rat IDH3B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey IDH3B-610C Recombinant Cynomolgus IDH3B Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IDH3B-356C-B Recombinant Cynomolgus Monkey IDH3B Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey IDH3B-356C Recombinant Cynomolgus Monkey IDH3B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IDH3B-2194R Recombinant Rhesus monkey IDH3B Protein, His-tagged Mammalian Cell His
Rhesus Macaque IDH3B-2015R-B Recombinant Rhesus Macaque IDH3B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IDH3B-2015R Recombinant Rhesus Macaque IDH3B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
S.cerevisiae ICDH-81 Active Recombinant Saccharomyces Cerevisiae ICDH protein Yeast N/A
Zebrafish IDH3B-381Z Recombinant Zebrafish IDH3B Mammalian Cell His
Pig ICDH-209S Active Native Swine Isocitrate Dehydrogenase Porcine Heart N/A
Chicken IDH3B-3038C Recombinant Chicken IDH3B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IDH3B Related Articles

IDH3B involved in several pathways and played different roles in them. We selected most pathways IDH3B participated on our site, such as Citrate cycle (TCA cycle), Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Citrate cycle (TCA cycle)PCK1;ACO2;MDH1AA;DLD;OGDHL;SDHA;IDH3A;PDHA1;MDH1
Metabolic pathwaysAMY2B;AMY1B;LSS;Amy1;GLUL;ALDH1B1;ATP5B;ATP6AP1;HADH
Carbon metabolismACADS;ENO1;PRPS2;ackA;PDHA2;SDSL;PRPS1;GPI1;ADPGK
-Oxocarboxylic acid metabolismIDH3G;IDH3A;ACO1;AADAT;GPT;BCAT2;GOT2A;GPT2;ACY1
Biosynthesis of amino acidsALDH7A1;GOT2A;THA1;RPE;ACY1;GOT2;GLUL;PYCR1A;GOT2B

IDH3B has several biochemical functions, for example, NAD binding, electron carrier activity, isocitrate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH3B itself. We selected most functions IDH3B had, and list some proteins which have the same functions with IDH3B. You can find most of the proteins on our site.

Function Related Protein
NAD bindingPHGDH;ME3;CTBP2A;NNT;AOX3L1;GPD1A;LDHB;HIBADHA;HSD11B2
electron carrier activityAKR7A2;FDX1;ME2;NOX4;SRD5A1;ALDH4A1;ACOX2;SDHD;COX7A3
isocitrate dehydrogenase (NAD+) activityIDH3B;IDH3G;IDH3A
magnesium ion bindingCIB3;PPA1A;STK11;ERN1;RRAGC;FDXACB1;NIM1K;RPS6KA4;IDH3A

IDH3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH3B here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH3B.

PHLDA3; RAB35; MAPK6; ATXN2; PRMT1; MYC; CLPP

Guay, C; Joly, E; et al. A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic beta-Cells. PLOS ONE 8:-(2013).
Li, HH; Su, JH; et al. Proteomic Investigation of the Sinulariolide-Treated Melanoma Cells A375: Effects on the Cell Apoptosis through Mitochondrial-Related Pathway and Activation of Caspase Cascade. MARINE DRUGS 11:2625-2642(2013).
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