Background
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs;with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its;receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of;low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript;variants encoding different isoforms have been described for this gene, and one variant has been associated with;retinal arterial macroaneurysm (PMID:21835307).