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IKBKAP

Official Full Name

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Overview

IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKa, IKK?, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation.
Synonyms

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; IKBKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1; FLJ12497; DKFZp781H1425; elongator complex protein 1; p150; OTTHUMP00000021869; IKK complex-associated protein; ikappaB kinase complex-associated protein;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	IKBKAP-497H	Recombinant Human IKBKAP Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Mouse	IKBKAP-8100M	Recombinant Mouse IKBKAP Protein	Mammalian Cell	His	Inquiry
Mouse	IKBKAP-4485M	Recombinant Mouse IKBKAP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	IKBKAP-4485M-B	Recombinant Mouse IKBKAP Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	IKBKAP-3021R	Recombinant Rat IKBKAP Protein	Mammalian Cell	His	Inquiry
Rat	IKBKAP-2676R	Recombinant Rat IKBKAP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	IKBKAP-2676R-B	Recombinant Rat IKBKAP Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein

IKBKAP involved in several pathways and played different roles in them. We selected most pathways IKBKAP participated on our site, such as IL-1 Signaling Pathway, TNF-alpha NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
IL-1 Signaling Pathway	IKBKAP;IL1RN;SIRPA
TNF-alpha NF-kB Signaling Pathway	SMARCA4A;SMARCB1A;NLRP4E;IKBKAP;TRAF4A;SMARCC1;TRPC4APA;CAPN3A;MTIF2

IKBKAP has several biochemical functions, for example, ATP binding, contributes_to RNA polymerase II core binding, phosphorylase kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKAP itself. We selected most functions IKBKAP had, and list some proteins which have the same functions with IKBKAP. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DHX58;RPS6KB1B;HIPK4;PAPSS2;DDX55;ROS1;TNK2B;BCKDK;P2RX3B
contributes_to RNA polymerase II core binding	ELP3;IKBKAP;ELP2;ELP4
phosphorylase kinase regulator activity	IKBKAP;ELP4;ELP3;PRKAG2
protein kinase activity	PRKCG;NEK5;TRIM28;MAP2K4B;VSIG8B;SMOK2B;OXSR1B;MAPKAPK2;FASTKD3

IKBKAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKAP.

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