IKBKB
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Official Full Name
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
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Overview
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). -
Synonyms
IKBKB; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; OTTHUMP00000225854; OTTHUMP00000225858; OTTHUMP00000225860; OTTHUMP00000225865; OTTHUMP00000225866; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- S.frugiperda
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- Flag
- GST
- GST|His
- His (Fc)
- Avi
- His|GST
- His|T7
- MYC
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
IKBKB involved in several pathways and played different roles in them. We selected most pathways IKBKB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | GNA12A;PLA2G4C;PRKACAB;IL1R1;HSPA2;FGF6A;NGF;RASGRF2B;PPP3CA |
| Ras signaling pathway | FGFR1;ETS2;PAK3;PLA2G4C;RAB5C;GNG8;RGL2;PIK3R2;FIGF |
| Chemokine signaling pathway | CXCL6;CCL1;BRAF;CCR3;Ccl21c;VAV3;GM2506;RAC1;WAS |
| NF-kappa B signaling pathway | SYK;CCL4L1;TNFSF13B;LTA;Ccl21a;GM13304;XIAP;IKBKB;Ccl21c |
| FoxO signaling pathway | GABARAPL1;PRKAG3B;INS2;TGFBR1B;PRKAB1A;RAG2;SGK2A;RAF1B;MDM2 |
| mTOR signaling pathway | TSC2;RHEB;AKT3A;VEGFA;PRKCB;RRAGD;TSC1B;PIK3R5;RPTOR |
| PIK-Akt signaling pathway | IFNAR1;G6PC3;NGF;PDPK1;FGF6;IL7R;CCNE2;INS;COL6A4 |
| Apoptosis | BCL2L1;PIK3CA;HMGB2A;BAD;NFKBIAB;ATM;MYD88;BADB;NFKBIAA |
| Osteoclast differentiation | CSF1;SIRPB1;MAPK13;RAC1;FOS;MAPK8;PPP3CC;ITGB3;CYLD |
| Toll-like receptor signaling pathway | MAP3K7;IFNA4;TLR2-1;IFNA10;TLR2;CXCL10;TLR4;Ifna15;MYD88 |
| NOD-like receptor signaling pathway | HSP90B1;CXCL2;PYCARD;TRIP6;CXCL1;PYDC1;NAIP1;MAPK3;NLRP3 |
| RIG-I-like receptor signaling pathway | IRF3;Ifna11;IFNA17;IFNA13;RIPK1;MAP3K1;IL-8;IFNB1;IFNA6 |
| Cytosolic DNA-sensing pathway | POLR3C;MAVS;IFNA4;IFNA7;POLR3E;RIPK1;IKBKB;IL6;IL1B |
| T cell receptor signaling pathway | NFKBIB;CD3E;IKBKB;PLCG1;LCP2;GRAPA;LCK;VAV2;AKT2 |
| B cell receptor signaling pathway | CSK;LYN;DAPP1;MAPK3;CD81;NRAS;CARD11;MAP4K1;CDK4 |
| TNF signaling pathway | MAP3K7IP3;RELA;CREB3L3;CXCL2;MAP3K14;MMP9;TNFRSF1A;TRADD;CXCL5 |
| Neurotrophin signaling pathway | NTRK1;RHOA;KRAS;SH2B3;BDNF;NTRK3;BCL2;YWHAE;MAPK9 |
| Insulin signaling pathway | HRASA;HK2;PHKA1;CBLB;PRKACG;AKT2L;IRS4;GRB2A;TSC1 |
| Adipocytokine signaling pathway | MAPK9;ADIPOR2;ACSL3A;PRKAB1B;RXRAA;G6PCA.1;PRKAA2;ACSL1B;JAK2B |
| Type II diabetes mellitus | PIK3CB;INS2;CACNA1G;IRS1;TNF;PKM;HK2;ADIPOQ;PRKCE |
| Insulin resistance | INSB;SLC2A1;SOCS3B;TNFRSF1A;PTENB;PPARAB;MAPK9;MAPK10;PPP1R3A |
| Non-alcoholic fatty liver disease (NAFLD) | FAS;IL6;PRKAG2;PIK3R5;NDUFV2;IL1A;NDUFV1;NDUFB9;INS |
| Epithelial cell signaling in Helicobacter pylori infection | MAPK9;CXCR2;RELA;NFKB1;ATP6V1C1;TCIRG1;CXCR1;MAPK10;PTPN11 |
| Shigellosis | ACTG1;IKBKG;MAPK9;U2AF1L4;RHOG;ABL1;DIAPH1;WAS;PFN1 |
| Chagas disease (American trypanosomiasis) | FOS;PPP2R2A;PIK3CD;TLR4;BDKRB2;CCL2;TNFRSF1A;IRAK1;GNAI2 |
| Toxoplasmosis | IL12A;TLR2;IRAK4;IL12B;ITGB1;RELA;IRGM;H2-AB1;PIK3R1 |
| Hepatitis C | IFIT1;IRF1;OAS1A;IKBKG;IFNA10;PIK3R1;NFKB1;CLDN6;STAT2 |
| Hepatitis B | IFNA4;HSPG2;IFN-a;IFNA2;PRKCG;MAPK1;PIK3CB;BAD;CREB3L1 |
| Influenza A | TNFRSF10D;TNFSF10;RAE1;CCL5;IFNA4;NFKB1;IFNA8;LOC100686744;IFNG |
| HTLV-I infection | NFKB1;PPP3R2;IL15RA;PRKACA;POLD1;HLA-DRB3;H2-AA;HLA-DRA;IL2RA |
| Herpes simplex infection | C3;HLA-DRA;PVRL2;TRAF1;CFP;TYK2;TNFRSF1A;POU2F3;MHC2DEB |
| Epstein-Barr virus infection | ICAM1;HLA-DRA;HSPA2;HLA-DPA1;HDAC4;POLR2L;HSPA1B;HDAC5;HLA-DRB1 |
| Pathways in cancer | ITGA3;LAMB3;GNG12;LPAR6;GNB3;RHOA;NKX3;MMP1A;CBLC |
| MicroRNAs in cancer | BRCA1;CCNE1;NOTCH1;CDCA5;BMI1;KRAS;MAPK7;UBE2I;ERBB2 |
| Pancreatic cancer | TGFB3;RALGDS;RAC3;BAD;KRAS;TGFBR1;AKT2;TRP53;IKBKG |
| Prostate cancer | CCNE1;BAD;FGFR1;NOXA1;HRAS;NRAS;RAF1;CREB3L2;IGF1 |
| Chronic myeloid leukemia | PIK3CB;MDM2;BCR;HDAC1;RELA;TGFB3;PIK3CA;PIK3R5;PIK3R2 |
| Acute myeloid leukemia | PIK3CB;MTOR;AKT1;PIK3R1;NFKB1;STAT3;KRAS;JUP;RAF1 |
| Small cell lung cancer | APAF1;SKP2;PIK3CD;LAMA1;COL4A1;LAMB1;AKT1;PIK3CA;PTEN |
IKBKB has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKB itself. We selected most functions IKBKB had, and list some proteins which have the same functions with IKBKB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PSTK;MTHFD1;PIK3CB;cka1;KIF13B;P2RY4;PRKX;BBS10;PDPK1A |
| IkappaB kinase activity | IKBKE;IKBKB;CHUK |
| protein binding | FGF19;NFS1;Car8;KRTAP3-2;CTNNB1;AGXT2L2;TXNL4B;ZNF567;CD8B |
| protein heterodimerization activity | CHUK;SYCP3;SOX5;BAK1;SMAD4;GCLC;SMAD1;PPP3CB;PEF1 |
| protein homodimerization activity | AXIN1;CHMP4A;IDE;LMLN;MASP1;UGT1A2;EFR3A;CD4;GABRR1 |
| protein kinase activity | RPS6KA6;PRKAG1;PRKACAB;NEK12;RIPK4;LTK;INSRB;CAMK2B1;PDK1 |
| protein kinase binding | NR4A3;TOM1L1;SLC12A7;TBL2;SYN1;GSK3B;PARK2;STK39;ACTA2 |
| protein serine/threonine kinase activity | ACVR1;RPS6KA1;TSSK2;cka1;DAPK3;NUAK1;GRK1A;STK39;SQSTM1 |
| scaffold protein binding | MDM2;KRT15;PARK7;P2RY1;CACNA1H;LRP4;DSP;TREM2;CRIPT |
IKBKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKB here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKB.
IKBKG
- Q&As
- Reviews
Q&As (5)
Ask a questionIKBKB protein is a key regulator of the NF-κB pathway, which plays a central role in the inflammatory response. Dysregulation of IKBKB can contribute to the development of inflammatory diseases.
Yes, dysregulation of IKBKB protein and the NF-κB pathway has been implicated in neuroinflammation and the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
Yes, targeting IKBKB protein or the NF-κB pathway is being explored as a potential strategy for treating autoimmune diseases by modulating the inflammatory response.
IKBKB protein activates the NF-κB pathway, which can promote cell survival and inhibit apoptosis in response to various stimuli, making it a potential target for cancer therapy.
Yes, mutations in the IKBKB gene have been associated with immunodeficiency disorders and inflammatory diseases, highlighting the importance of IKBKB protein in immune system function.
Customer Reviews (3)
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