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IKBKB

  • Official Full Name

    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

  • Overview

    NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
  • Synonyms

    IKBKB; IKK2; IKKB; NFKBIKB; FLJ33771; FLJ36218; FLJ38368; FLJ40509; IKK-beta; MGC131801; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; OTTHUMP00000225854; OTTHUMP00000225858; OTTHUMP00000225860; OTTHUMP00000225865; OTTHUMP00000225866; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • S.frugiperda
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IKBKB-88H Active Recombinant Human IKKB-beta Sf9 Insect Cell GST/His
Human IKBKB-87H Recombinant Human IKBKB Protein, His-tagged E. coli His 1-756aa
Human IKBKB-1027H Recombinant Human Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta, GST-tagged Sf9 Insect Cell GST
Human IKBKB-14132H Recombinant Human IKBKB, GST-tagged E.coli GST 1-256a.a.
Human IKBKB-53H Recombinant Human IKBKB protein, Flag-tagged, Biotinylated Insect Cell Flag
Human IKBKB-89H Recombinant Human IKB-beta E.coli GST
Human IKBKB-501H Recombinant Human IKBKB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IKBKB-125H Recombinant Human IKBKB protein, GST-tagged Insect Cell GST
Human IKBKB-760H Recombinant Human IKBKB, His-S S.frugiperda His
Human IKBKB-28877TH Recombinant Human IKBKB Wheat Germ N/A 256 amino acids
Human IKBKB-2661H Recombinant Human IKBKB, GST-His Sf9 Insect Cell GST
Human IKBKB-849HCL Recombinant Human IKBKB cell lysate N/A
Human IKBKB-1162H-B Recombinant Human IKBKB Protein Pre-coupled Magnetic Beads HEK293
Human IKBKB-3571H Recombinant Human IKBKB protein, His-tagged E.coli His 1-256 aa
Human IKBKB-1720H Recombinant Human IKBKB protein, His & GST-tagged E.coli His/GST Asp246~Val528 (Accession # O14920)
Human IKBKB-255HF Recombinant Full Length Human IKBKB Protein In Vitro Cell Free System 256 amino acids
Human IKBKB-2231H Recombinant Human IKBKB protein, His-tagged Yeast His 1-756aa
Human IKBKB-1064H Recombinant Human IKBKB Protein (S695-S756), Tag Free Insect Cell No tag S695-S756
Human IKBKB-421HFL Active Recombinant Full Length Human IKBKB Protein, C-Flag-tagged Mammalian cells Flag
Human IKBKB-1162H Recombinant Human IKBKB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IKBKB-1065H Recombinant Human IKBKB Protein (S695-S756), GST tagged Insect Cell GST S695-S756
Mouse Ikbkb-1721M Recombinant Mouse Ikbkb protein, His & T7-tagged E.coli His/T7 Met1~Trp231 (Accession # O88351)
Mouse Ikbkb-5691M Recombinant Mouse Ikbkb Protein (Ser2-Asp757), C-His tagged E.coli C-His Ser2-Asp757
Mouse Ikbkb-1232M Recombinant Mouse Ikbkb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque IKBKB-2225R Recombinant Rhesus monkey IKBKB Protein, His-tagged Mammalian Cell His
Rhesus Macaque IKBKB-2046R Recombinant Rhesus Macaque IKBKB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IKBKB-2046R-B Recombinant Rhesus Macaque IKBKB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IKBKB-6658Z Recombinant Zebrafish IKBKB Mammalian Cell His
Chicken IKBKB-3048C Recombinant Chicken IKBKB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

IKBKB involved in several pathways and played different roles in them. We selected most pathways IKBKB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNA2D2;RAF1B;MAP2K6;PPP3CCA;MAPK12A;CACNB4A;FGF9;GRB2;TNFRSF1A
Ras signaling pathwayPRKCB;RALBP1;CALML3;RASA4;RASSF5;RALGDS;GRIN2A;PLA2G3;ANGPT4
Chemokine signaling pathwayCXCL1;CCR6;PIK3CD;CCL25;GNB1;CX3CL1;GNG8;CXCL5;PIK3CB
NF-kappa B signaling pathwayCD40LG;TRAF3;RIPK1;IL1B;GM10591;CD40;PIAS4;PIDD1;ICAM1
FoxO signaling pathwayHRASB;PLK1;MAPK14A;TGFB1;AKT2;SGK2A;PRKAG2A;NLK2;PRMT1
mTOR signaling pathwayRPS6;ULK1;STK11;PIK3R1;PRKCBA;PDPK1;PIK3CD;RRAGD;RICTOR
PIK-Akt signaling pathwaySOS1;IFNB1;SGK3;AKT2;IL2RB;LPAR6;HGF;ITGB7;ITGB8
ApoptosisDSG2;PIK3CD;FASLG;STK24;FAS;IL1A;IKBKB;IKBKG;BOK
Osteoclast differentiationTGFB2;LCP2;SIRPG;SIRPA;PPP3CC;FCGR1A;RAC1;TGFBR1;IFNAR1
Toll-like receptor signaling pathwayIFNPHI3;MAP2K4A;MAPK13;TLR1LB;MAPK9;IFNAR2;CASP8;Ifna11;IFNA2
NOD-like receptor signaling pathwayMAPK12B;CARD8;IL6;NFKBIAB;MAPK14A;IKBKB;RELA;NFKBIAA;CASPA
RIG-I-like receptor signaling pathwayNFKBIA;IFIH1;CXCL8B.3;TBKBP1;MAPK8B;Ifna11;PIN1;MAPK12A;TRAF3
Cytosolic DNA-sensing pathwayPOLR3G;IFNA2;CASPA;IFNA8;IFNB;IL1B;NFKB1;IFNA21;IFNA7
T cell receptor signaling pathwaySOS1;PLCG1;RELA;NFKB1;GSK3B;EVLB;KRAS;PAK1;CD8B
B cell receptor signaling pathwayRASGRP3;MAPK3;LCP2A;GRB2;CDK2;BLNK;ITK;IFITM1;VAV3
TNF signaling pathwayAKT1;IL18R1;MAPK1;CASP7;PIK3R5;MLKL;LTA;CASP8;CREB3L2
Neurotrophin signaling pathwayBRAF;MAP2K2;NFKBIE;HRAS;PIK3R5;MAP2K5;SH2B3;MAP2K7;IRAK4
Insulin signaling pathwayPRKAG3B;PRKAR2AA;PTPRF;PRKAR1A;PRKAA2;CALM3;PRKACBB;CBLC;SOCS3
Adipocytokine signaling pathwayACSL1;LEP;G6PC;ACSL5;TRAF2;PPARA;MAPK9;MAPK8B;NPY
Type II diabetes mellitusHK1;MTOR;MAPK3;PRKCE;PIK3CA;SOCS4;IRS1;PRKCD;MAPK10
Insulin resistancePRKCBB;PTPN11;NFKBIAA;PPP1CAA;IRS1;NR1H2;PYGL;PPP1R3A;PIK3R3B
Non-alcoholic fatty liver disease (NAFLD)COX8C;NDUFB7;NDUFA11;PIK3CA;IL1B;CASP7;GSK3A;SREBF1;SOCS3
Epithelial cell signaling in Helicobacter pylori infectionTJP1;NOD1;MAPK9;GIT1;ATP6V1G1;ATP6AP1;SRC;PLCG2;ATP6V1E2
ShigellosisDIAPH1;ROCK1;HCLS1;PFN3;ACTG1;PFN4;WASL;ELMO2;ITGA5
Chagas disease (American trypanosomiasis)PPP2R2D;AKT2;C3;GNAI1;TGFB3;IL12A;IL1B2;PIK3R5;IKBKB
ToxoplasmosisToxoplasma Gondii Profilin Family Protein;TLR4;BCL2L1;GNAI2;LDLR;LAMB3;CD40;HLA-DPA1;PIK3R1
Hepatitis CMAPK1;NFKBIA;IFNB1;RXRA;EIF2AK2;GSK3B;MAPK10;RAF1;IFNA2
Hepatitis BPTEN;STAT3;PRKCA;STAT5A;EP300;HSPG2;MAP2K1;IFNA5;MAP2K2
Influenza ASTAT2;CXCL8;DDX39B;TLR7;IFNB1;PIK3CD;EIF2AK1;NXT2;TMPRSS2
HTLV-I infectionHLA-DRB1;HLA-DRA;CCND1;CANX;PDGFRB;WNT16;ANAPC7;Il2;KAT2A
Herpes simplex infectionSRSF4;MAPK8;BLB2;IFNA5;TNFB;C5;SRSF1;HLA-DQA2;CYCSB
Epstein-Barr virus infectionPOLR1D;HLA-DQA1;CD58;IFNG;CDK1;PTMA;CCNA2;GTF2B;EIF2AK4
Pathways in cancerKIT;PTGER3;CTBP2;TGFB3;SOS1;VEGFA;LAMA2;PPARD;CTNNA3
MicroRNAs in cancerPdgfa&Pdgfb;MMP16;EP300;PIM1;GLS2;Casp3;SOCS1;MAPK7;CDC25B
Pancreatic cancerPLD1;CCND1;CDC42;SMAD2;TGFB3;IKBKB;RAC2;ERBB2;PIK3R2
Prostate cancerINSRR;RB1;NFKB1;HSP90AB1;HRAS;PIK3R2;RAF1;INS;ARID1A
Chronic myeloid leukemiaTRP53;PIK3R5;BCR;ARAF;NFKBIA;TP53;SHC3;PIK3R1;AKT1
Acute myeloid leukemiaMAP2K2;SOS1;PIK3R1;RPS6KB1;PIM1;FLT3;ARAF;CEBPA;STAT5B
Small cell lung cancerPIAS2;LAMA4;PTEN;PIK3R1;FN1;BCL2;BCL2L1;LAMB3;IKBKG

IKBKB has several biochemical functions, for example, ATP binding, IkappaB kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKB itself. We selected most functions IKBKB had, and list some proteins which have the same functions with IKBKB. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPIP4K2C;CLCN4-2;SMC1A;RAF1A;ALK;ABCG2;DTYMK;CAMK1D;ERCC6
IkappaB kinase activityIKBKB;CHUK;IKBKE
protein bindingTARS;SVIL;CRKL;RET;PLA2G16;SNW1;ISY1;SETD7;TRIM9
protein heterodimerization activityHIST1H2AC;GRIN1;XBP1;HIST1H4A;IKZF2;RAB3GAP2;CEBPE;HIST3H3;TBX18
protein homodimerization activityVPS25;Bcl2a1b;TENM1;CALCOCO2;DMRTC1B;CD226;PEX11A;SNF8;ERN1
protein kinase activityMAP3K11;STK26;AURKC;STK24;TEX14;LMTK3;PTK2BB;PRKG2;PKN1
protein kinase bindingCCNY;CRY1;RAD9A;SPDYA;ADAM10;FAM83D;SPDYE2;CACNB4;CDK5RAP2
protein serine/threonine kinase activitySMOK2B;MYO3A;SYK;STK3;MAP3K12;WNK1;SNRKA;DCLK1;PRKG1A
scaffold protein bindingCASP8;CHUK;KCNH2;CHRNA7;NLGN3;TREM1;P2RY1;CAV2;KRT15

IKBKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKB here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKB.

IKBKG

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is IKBKB protein involved in inflammatory diseases? 02/24/2023

IKBKB protein is a key regulator of the NF-κB pathway, which plays a central role in the inflammatory response. Dysregulation of IKBKB can contribute to the development of inflammatory diseases.

Can dysregulation of IKBKB protein contribute to neurodegenerative diseases? 11/05/2020

Yes, dysregulation of IKBKB protein and the NF-κB pathway has been implicated in neuroinflammation and the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Is there any potential for targeting IKBKB protein in the treatment of autoimmune diseases? 08/21/2020

Yes, targeting IKBKB protein or the NF-κB pathway is being explored as a potential strategy for treating autoimmune diseases by modulating the inflammatory response.

How is IKBKB protein involved in the regulation of cell survival and apoptosis? 08/28/2019

IKBKB protein activates the NF-κB pathway, which can promote cell survival and inhibit apoptosis in response to various stimuli, making it a potential target for cancer therapy.

Can mutations in the IKBKB gene lead to human diseases? 12/23/2018

Yes, mutations in the IKBKB gene have been associated with immunodeficiency disorders and inflammatory diseases, highlighting the importance of IKBKB protein in immune system function.

Customer Reviews (3)

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Reviews
04/26/2020

    Their team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.

    09/24/2018

      Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.

      04/13/2016

        This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.

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