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IKZF2

Official Full Name

IKAROS family zinc finger 2 (Helios)
Overview

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
Synonyms

IKZF2; IKAROS family zinc finger 2 (Helios); zinc finger protein, subfamily 1A, 2 (Helios) , ZNFN1A2; zinc finger protein Helios; Helios; ikaros family zinc finger protein 2; zinc finger DNA binding protein Helios; zinc finger protein, subfamily 1A, 2 (Helios); ANF1A2; ZNF1A2; ZNFN1A2; MGC34330;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IKZF2-5252HCL	Recombinant Human IKZF2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	IKZF2-32H	Recombinant Human IKZF2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	IKZF2-8105M	Recombinant Mouse IKZF2 Protein	Mammalian Cell	His		Inquiry
Mouse	Ikzf2-3089M	Recombinant Mouse Ikzf2 protein, His&Myc-tagged	E.coli	His&Myc	1-526aa	Inquiry
Mouse	IKZF2-4487M	Recombinant Mouse IKZF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	IKZF2-4487M-B	Recombinant Mouse IKZF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	IKZF2-2226R	Recombinant Rhesus monkey IKZF2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	IKZF2-2047R	Recombinant Rhesus Macaque IKZF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	IKZF2-2047R-B	Recombinant Rhesus Macaque IKZF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	IKZF2-6175C	Recombinant Chicken IKZF2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
IKZF2 Related Research Area

IKZF2 involved in several pathways and played different roles in them. We selected most pathways IKZF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IKZF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

IKZF2 has several biochemical functions, for example, metal ion binding, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKZF2 itself. We selected most functions IKZF2 had, and list some proteins which have the same functions with IKZF2. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	LTN1;RHEBL1;FEZF2;CYP2AA12;ZFP879;BMPR1A;SP6;ZBTB11;VSNL1A
molecular_function	ARXES2;VMN1R139;GM3258;SNAPC1A;RPL37;Sez6l;SPSB2;PRRT3;SKINT9
protein binding	ZNF202;ROBO2;NR1H2;ZBTB7C;ZFP64;KCTD6;TTYH2;ELANE;FSHB
protein heterodimerization activity	BMP6;SYT10;JAM2A;BMP7A;GABPB1;PPP3CB;PVRL1;Bcl2a1b;SUPT5H
protein homodimerization activity	AMICA1;PDK2;NTRK2;FIGF;SLC16A1;PVRL1B;DMRT2;ADRB3;FASN
transcription factor activity, sequence-specific DNA binding	CREM;UBN2A;VED;SLC26A3;PLAGX;ZBTB48;FOXO3B;MYCLB;KLF10
transcription regulatory region DNA binding	SOX6;SALL4;TP73;KLF2A;ARID5A;Ar;ZBTB14;NR1H3;XRCC5

IKZF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKZF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IKZF2.

Hoxa1; AQP1; CTBP2; LONRF1; CTBP2; MYC; HDAC1

Hematopoietic Stem Cell Transcription Factors and Regulators