IL13
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Official Full Name
interleukin 13
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Overview
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. -
Synonyms
ALRH; BHR1; P600; IL-13; interleukin-13; allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma); NC30; Tralokinumab; 1044515-88-9; Lebrikizumab; 953400-68-5; Anrukinzumab (= IMA-638); 910649-32-0;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- GMP Proteins
- Antibody
- Therapeutic Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Canine
- Cattle
- Chicken
- Cotton Rat
- Cynomolgus
- Cynomolgus Monkey
- Dog
- Equine
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus
- Rhesus Macaque
- Rhesus monkey
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293F
- Human
- Human Cell
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- Rat
- Yeast
- APC
- C
- Fc
- His
- hFc
- Myc
- HIgG1 Fc
- tagged
- His (Fc)
- Avi
- His(C
- ter)
- His|Biotin
- His|DDK
- His|GST
- His|T7
- human|IgG1|Fc
- mFc
- N/A
- N
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- IL13 Related Articles
- IL13 Related Gene Family
IL13 involved in several pathways and played different roles in them. We selected most pathways IL13 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Fc epsilon RI signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | ACKR3B;EGFRA;PDGFB;CCL19B;NGFRB;IL24;PRP2;IFNGR2;IFNPHI1 |
Jak-STAT signaling pathway | Ifnlr1;IFNK;GFAP;IL22RA2;IL24;CSF3;Ifnl2;IL6ST;HRASB |
Fc epsilon RI signaling pathway | PLA2G4A;PIK3CD;FCER1G;VAV2;RAF1;MAPK3;MAP2K6;MAP2K2;TNF |
Measles | CCND1;AKT1;IFNA13;Il2;IL2RB;OAS1;IFNA17;CD3E;IRAK1 |
Asthma | FCER1A;EPX;HLA-DRB1;CD40;HLA-DOA;HLA-DPB1;HLA-DMB;IL5;HLA-DMA |
Inflammatory bowel disease (IBD) | HLA-DPB1;IL23R;IL2RG;HLA-DRB1;IL1A;IL4R;IFNGR1;RORC;IL21 |
IL13 has several biochemical functions, for example, cytokine activity, interleukin-13 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL13 itself. We selected most functions IL13 had, and list some proteins which have the same functions with IL13. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | SPP1;IL7;IL21;HMGB1B;CMTM2;IL1RN;IL36B;CCL20A.3;CCL19A.1 |
interleukin-13 receptor binding | |
protein binding | LRP5;ARVCF;EAF2;MED9;ABCF1;TPD52;COMP;SENP1;TUBA1C |
IL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL13.
IL13RA1
- Q&As
- Reviews
Q&As (10)
Ask a questionFlow cytometry quantifies IL13 receptor expression on cells.
Transgenic models illuminate IL13's in vivo functions.
ELISA quantifies IL13 secretion in cell cultures accurately.
siRNA knockdown uncovers IL13's specific cellular effects.
Co-immunoprecipitation identifies IL13 signaling partners.
Differential techniques distinguish IL13 and IL4 signaling pathways.
Reporter gene assays gauge IL13-driven transcription.
Microarray analysis profiles IL13-induced gene expression.
Experimental methods reveal IL13's impact on tissue remodeling.
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
Customer Reviews (3)
Write a reviewEffective in Th2 cell differentiation.
Good for cytokine assays.
High yield in expression.
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