IL15RA
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Official Full Name
interleukin 15 receptor, alpha chain
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Overview
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and -
Synonyms
IL15RA; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; CD215; I15RA_HUMAN; IL 15R alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; Interleukin 15 receptor alpha; Interleukin 15 receptor subunit alpha; MGC104179; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA; Soluble interleukin 15 receptor subunit alpha; Soluble interleukin-15 receptor subunit alpha; OTTMUSP00000011997; OTTMUSP00000011998; OTTMUSP00000011999; OTTMUSP00000051896; OTTMUSP00000051897; OTTMUSP00000051898; OTTMUSP00000051899; OTTMUSP00000051901; OTTMUSP00000051907; IL-15 receptor subunit al; AA690181;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- CHO
- CHO cells
- E. coli
- E.coli
- HEK293
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Mouse myeloma cell line
- Sf21 Insect Cell
- Wheat Germ
- C
- Fc
- His
- Avi
- Fc|His
- His (Fc)
- Myc
- His|HIgG
- human|IgG1|Fc
- N/A
- N
- GST
- Involved Pathway
- Protein Function
- Interacting Protein
- IL15RA Related Articles
- IL15RA Related Gene Family
- IL15RA Related Research Area
IL15RA involved in several pathways and played different roles in them. We selected most pathways IL15RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL15RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | GM2002;BMP7;BMPR1BA;TGFB2;PDGFA;EDA2R;EPO;BMPR2A;BMP2 |
| Jak-STAT signaling pathway | IFNAR1;IFNA10;IFNA12;SOCS5;STAT1A;M17;SOCS4;CCND3;LIF |
| Intestinal i | ICOSLG;CD86;TNFRSF13B;HLA-DPA1;CXCL12B;MADCAM1;IL-15RA;IL5;HLA-DRB4 |
| ne network for IgA production | MHC2DEB;BLB2;HLA-DRB1;ICOS;CD28;CCR10;HLA-DRB5;BLA;CXCL12A |
| HTLV-I infection | TSPO;VAC14;ICAM1;NFKBIA;ELK1;TP53;TNFRSF1A;MAP3K1;TBP |
IL15RA has several biochemical functions, for example, cytokine receptor activity, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL15RA itself. We selected most functions IL15RA had, and list some proteins which have the same functions with IL15RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine receptor activity | IL12RB1;IL2RGA;IL15RA;LIFRA;LEPR;IL21R.2;IL31RA;GHR;F3B |
| protein binding | PLD2;BMI1;HOXA1;SERPINF2;APOE;KLHL38;LSM6;RPS6KA2;DIEXF |
| signal transducer activity | SLC35B2;NFKBIB;GPR139;AIP;ADRA1BB;VMN1R47;OLFR10;PTK2AA;OLFR78 |
IL15RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL15RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL15RA.
IL15; IL2RB; IL2RG; CASK; BCL10; CDK4; CDK2; RCVRN; PIAS4
- Q&As
- Reviews
Q&As (10)
Ask a questionImmunoprecipitation validates IL15RA's binding to IL2RB in cells.
CRISPR/Cas9 technology aids in generating IL15RA knockout models.
Approaches unravel IL15RA's implication in autoimmune disease mechanisms.
Methods discern IL15RA's distinct roles in innate and adaptive immunity.
RT-PCR and Western blotting assess IL15RA isoform expression patterns.
Binding affinity of IL15RA to IL15 quantified through surface plasmon resonance.
Proliferation assays investigate IL15RA's contribution to immune cell growth.
IL15RA's interaction with JAK/STAT pathways probed using immunoblotting.
siRNA knockdown studies unveil IL15RA's impact on downstream signaling.
FRET assays employed to elucidate IL15RA dimerization kinetics.
Customer Reviews (3)
Write a reviewEffective in T-cell assays.
High purity levels.
Consistent receptor binding.
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