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IL1B

  • Official Full Name

    interleukin 1 beta

  • Overview

    Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. This antibody is a human monoclonal anti-human IL1Beta antibody of the IgG1/ Kappa isotype. It binds to human IL1Beta and neutralizes its activity by blocking its interaction with IL1 receptors, but it does not bind IL1α or IL1 receptor antagonist (IL1 ra).
  • Synonyms

    Il1b; RP23-384K11.2; IL-1beta; Il-1b; Catabolin; IL-1; Lymphocyte-activating factor; LAF; Endogenous Pyrogen; EP; Leukocyte Endogenous Mediator; LEM; Mononuclear Cell Factor; MCF; IL1F2, Interleukin-1 beta; pro-interleukin-1-beta; Interleukin-1 beta precursor; preinterleukin 1 beta; H1; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL-1 beta; IL1 BETA; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; Interleukin-1 beta; OAF; Osteoclast activating factor; OTTHUMP00000162031; Preinterleukin beta; Pro interleukin 1 beta; Gene name: IL1B; NM_000576.2; NP_000567.1; UniProt ID: P01584; P01584; 2q14; Canakinumab; Ilaris; Entrez: 3553; Entrez Gene: 3553; Gene ID: 3553; MIM: 147720; IL1-BETA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Transfected Stable Cell Lines
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Cattle
  • Chicken
  • Cotton Rat
  • Cynomolgus
  • Cynomolgus Monkey
  • Dog
  • Feline
  • Guinea pig
  • Horse
  • Human
  • Monkey
  • Mouse
  • Ovine
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Sheep
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human cells
  • Human Cells
  • Mammalian Cell
  • Mammalian cells
  • Monkey
  • Rabbit
  • Yeast
  • C
  • His
  • Fc
  • Flag
  • GST
  • HIgG1 Fc
  • His (Fc)
  • Avi
  • Myc
  • His(C
  • ter)
  • His|GST
  • His|S
  • His|T7
  • SUMO
  • Met
  • DDK
  • MYC
  • N/A
  • N
  • No tag
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL1B-9908H Active Recombinant Human IL1B CHO N/A
Human Il1B-464H Active Recombinant Human Il1B, HIgG1 Fc-tagged, mutant CHO Fc
Human IL1B-027E Active Recombinant Human IL1B (117-269aa) E.coli N/A
Human IL1B-465H Active Recombinant Human IL1B, MIgG2a Fc-tagged CHO Fc
Human IL1B-23H Active Recombinant Human IL1B E.coli N/A
Human IL1B-339H Active Recombinant Human IL1B Human N/A
Human IL1B-461H Active Recombinant Human Interleukin 1, Beta E.coli N/A
Human IL1B-02H Recombinant Human IL1B protein E.coli N/A 153
Human IL1B-134H Recombinant Human Interleukin 1, Beta, His-tagged E.coli His
Human IL1B-744H Active Recombinant Human IL1B protein(Met1-Ser269), His-tagged E. coli N-His Met1-Ser269
Human IL1B-14167H Recombinant Human IL1B, GST-tagged E.coli GST 1-269a.a.
Human IL1b-82H Recombinant Human IL-1 beta Yeast N/A
Human IL1B-60H Recombinant Human IL1B, His-tagged E.coli His
Human Il1B-466H Recombinant Human Il1B, HIgG1 Fc-tagged CHO HIgG1 Fc
Human IL1B-132H Active Recombinant Human IL1B Protein E. coli N/A
Human IL1B-460H Recombinant Human IL1B protein, His-tagged HEK293 His Ala117-Ser269
Human IL1B-321H Recombinant Human IL1B, His-tagged E.coli His
Human IL1B-853HCL Recombinant Human IL1B cell lysate N/A
Human CAB11564RH Rabbit Anti-Human IL1B / IL1F2 Monoclonal Antibody Rabbit N/A
Human IL1B-83H Human Interleukin-1 Beta (rDNA derived) Reference standard N/A
Human IL1B-4316HG GMP Recombinant Human IL1B protein E.coli N/A 153
Human Il1B-39H Recombinant Human Il1B protein, low endotoxin E.coli Ala117-Ser269
Human IL1B-059H Active Recombinant Human IL1B Protein E. coli
Human IL1B-102HG Active GMP Recombinant Human IL1B Protein E. coli
Human IL1B-364H Active Recombinant Human IL1B Protein Human Cells N/A
Human IL1B-5955H Recombinant Human IL1B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL1B-05H Active Recombinant Human IL1B Protein, Pre-aliquoted E.coli Ala117-Ser269
Human IL1B-2121H Active Recombinant Human IL1B protein, Fc-tagged HEK293 Fc Ala117-Ser269
Human IL1B-3097H Recombinant Human IL1B protein, GST-tagged E.coli GST 117-269aa
Human IL1B-3096H Recombinant Human IL1B protein, His-SUMO-tagged E.coli His-SUMO 117-269aa
Human IL1B-29H Active Recombinant Human IL1B Protein, Animal Free Human cells
Human IL1B-162H Recombinant Active Human IL1B Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL1B-40H Recombinant Human IL1B Protein E.coli
Human IL1B-250I Active Recombinant Human IL1B Protein CHO
Human IL1B-28HG Active Recombinant Human IL1B Protein (Ala117-Ser269), GMP Grade, Animal-Free E.coli Ala117-Ser269
Human IL1B-150H Active Recombinant Human IL1B Protein E.coli
Human IL1B-52H Recombinant Human IL1B Protein, GST-tagged E.coli GST
Human IL1B-366I Active Recombinant Human IL1B Protein (153 aa) E.coli 153
Human IL1B-2466H Recombinant Human IL1B Protein (Ala117-Ser268), His tagged E.coli His Ala117-Ser268
Human IL1B-69H Recombinant Human IL1B Protein E.coli Ala117-Ser269
Human IL1B-313HFL Recombinant Full Length Human IL1B Protein, C-Flag-tagged Mammalian cells Flag
Human IL1B-101I Active Recombinant Human IL1B Protein (153 aa) E.coli 153
Human IL1B-1170H Recombinant Human IL1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL1B-0849H Recombinant Human IL1B Protein (A117-S269), Tag Free E.coli No tag A117-S269
Human IL1B-1170H-B Recombinant Human IL1B Protein Pre-coupled Magnetic Beads HEK293
Human IL1B-0850H Recombinant Human IL1B Protein (A117-S269), His tagged E.coli His A117-S269
Human IL1B-1602H Active Recombinant Human IL1B protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala117-Ser269
Human IL1B-244H Active Recombinant Human IL1B Protein E.coli Tag Free
Human IL1B-2465H Recombinant Human IL1B Protein (Ala117-Ser269), C-His tagged E.coli C-His Ala117-Ser269
Human IL1B-163H Active Recombinant Human IL1B Protein (Ala117-Ser269), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala117-Ser269
Mouse Il1b-040E Active Recombinant Mouse Il1b (118-269aa), Met tagged E.coli N/A
Mouse Il1b-462M Active Recombinant Mouse Interleukin 1 Beta E.coli N/A
Mouse Il1b-603M Active Recombinant Mouse Il1b E.coli Met Val118-Ser269
Mouse Il1b-8899M Active Recombinant Mouse Il1b CHO N/A
Mouse IL1b-01M Active Recombinant Mouse IL1b Protein, His-Tagged E.coli His
Mouse Il1b-105M Recombinant Mouse Interleukin 1 Beta, His-tagged E.coli His
Mouse Il1b-383M Active Recombinant Mouse Il1b protein E.coli N/A Val118-Ser269
Mouse Il1b-04M Recombinant Mouse Il1b protein E.coli N/A 152
Mouse Il1b-2831M Recombinant Mouse Il1b protein, His & T7-tagged E.coli His/T7 Val118~Ser269 (Accession # P10749)
Mouse Il1b-509M Recombinant Mouse Il1b protein, His-tagged HEK293F His Val118~Ser269
Mouse IL1B-8135M Recombinant Mouse IL1B Protein Mammalian Cell His
Mouse Il1b-2830M Recombinant Mouse Il1b protein, His & GST-tagged E.coli His/GST Val118~Ser269 (Accession # P10749)
Mouse IL1B-4503M Recombinant Mouse IL1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IL1B-4503M-B Recombinant Mouse IL1B Protein Pre-coupled Magnetic Beads HEK293
Mouse Il1b-55M Active Recombinant Mouse Il1b Protein (Val118-Ser269), C-His tagged, Animal-free, Carrier-free E.coli C-His Val118-Ser269
Mouse Il1b-100M Active Recombinant Mouse Il1b Protein E.coli
Mouse Il1b-249I Active Recombinant Mouse Il1b Protein CHO
Mouse IL1B-1603M Active Recombinant Mouse IL1B protein, His-tagged E.coli His Val118-Ser269
Mouse Il1b-365I Active Recombinant Mouse Il1b Protein (153 aa) E.coli 153
Mouse Il1b-101M Active Recombinant Mouse Il1b Protein E.coli
Mouse Il1b-103M Recombinant Mouse Il1b Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Il1b-6735M Recombinant Mouse Il1b Protein (Val118-Ser269) E.coli Tag Free Val118-Ser269
Mouse Il1b-632M Active Recombinant Mouse Il1b Protein E.coli Tag Free
Mouse IL1B-151M Active Recombinant Mouse IL1B Protein E.coli
Mouse Il1b-5314M Recombinant Mouse Il1b protein, His-tagged E.coli His 119-268aa
Mouse Il1b-161M Recombinant Active Mouse IL1B Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il1b-030I Active Recombinant Mouse Il1b Protein (153 aa) E.coli 153
Mouse Il1b-7238M Recombinant Mouse Il1b Protein, His-tagged E.coli His 118-269
Mouse Il1b-102M Active Recombinant Mouse Il1b Protein E.coli
Mouse Il1b-133M Mouse Interleukin-1 beta (rDNA derived) Reference standard N/A
Rat Il1b-463R Active Recombinant Rat Interleukin-1 beta E.coli N/A
Rat Il1b-93R Recombinant Rat Il1b protein E.coli N/A 153
Rat Il1b-384R Recombinant Rat Il1b protein(Met1-Ser268), His-tagged E. coli N-His Met1-Ser268
Rat IL1B-577R Recombinant Rat IL1B, His tagged E.coli His
Rat Il1b-1019R Recombinant Rat Il1b Protein, His-tagged HEK293F N-His Val117-Ser268
Rat Il1b-180I Active Recombinant Rat Il1b Protein HEK293
Rat Il1b-1020R Recombinant Rat Il1b Protein, His-tagged HEK293F N-His Val117-Ser268
Rat Il1b-363I Active Recombinant Rat Il1b Protein (152 aa) E.coli 152
Rat IL1B-152R Active Recombinant Rat IL1B Protein E.coli
Monkey IL1B-394M Active Recombinant Monkey Interleukin 1 Beta Monkey N/A
Rabbit IL1B-667R Active Recombinant Rabbit IL1B protein(Ala117-Ser268) E. coli N/A Ala117-Ser268
Rabbit IL1B-2834R Recombinant Rabbit IL1B protein, His & T7-tagged E.coli His/T7 Val118~Ser268 (Accession # P14628)
Dog IL1B-2827D Recombinant Dog IL1B protein, His-tagged E.coli His Cys103~Thr260 (Accession # Q2VCE2)
Dog IL1B-019D Active Recombinant Dog IL1B Protein E. coli
Bovine IL1B-232B Recombinant Bovine Interleukin 1, Beta Yeast N/A
Canine IL1B-656C Active Recombinant Canine IL1B E.coli N/A
Canine IL1B-243C Recombinant Canine Interleukin 1, Beta Yeast N/A
Canine Il1b-25C Recombinant Canine IL-1 beta Yeast N/A
Canine IL1B-920C Active Recombinant Canine IL1B Protein (Ala115-Ser266) E.coli N/A Ala115-Ser266
Cattle IL1B-2826C Recombinant Cattle IL1B protein, His & T7-tagged E.coli His/T7 Met1~Pro266 (Accession # P09428)
Cattle IL1B-1022C Recombinant Cattle IL1B Protein, His-tagged E.coli N-His Ile109-Val251
Cotton Rat Il1b-390C Active Recombinant Cotton Rat Il1b, Met-tagged E.coli Met
Cynomolgus IL1B-2166C Recombinant Cynomolgus IL1B protein, His-tagged E.coli His Ala 117 - Ser 268
Cynomolgus Monkey IL1B-1167C Active Recombinant Cynomolgus IL1B Protein E.coli N/A
Feline IL1B-1030F Active Recombinant Feline IL1B protein(Ala116-Ser267) E. coli N/A Ala116-Ser267
Feline IL1B-259F Recombinant Feline Interleukin 1, Beta Yeast N/A
Guinea pig Il1b-2829G Recombinant Guinea pig Il1b protein, His & S-tagged E.coli His/S Thr115~Ser266 (Accession # Q9WVG1)
Horse IL1B-251E Recombinant Horse IL1B protein E.coli N/A 153
Horse IL1B-2828H Recombinant Horse IL1B protein, His-tagged E.coli His His63~Val247 (Accession # Q28386)
Ovine IL1b-56O Recombinant Ovine IL-1 beta Yeast N/A
Porcine IL1B-01P Active GMP Recombinant Porcine IL1B Protein, His-Tagged E.coli His
Rhesus IL1B-1167R Active Recombinant Rhesus IL1B Protein E.coli N/A Ala117-Ser269
Rhesus IL1B-559R Recombinant Rhesus IL1B protein E.coli N/A 153
Rhesus Macaque IL1B-2239R Recombinant Rhesus monkey IL1B Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL1B-2060R-B Recombinant Rhesus Macaque IL1B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL1B-2060R Recombinant Rhesus Macaque IL1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sheep IL1B-2832S Recombinant Sheep IL1B protein, His & T7-tagged E.coli His/T7 Met1~Pro266 (Accession # P21621)
Sheep IL1B-5445S Recombinant Sheep IL1B protein, His-tagged Yeast His 114-266aa
Sheep IL1B-3098S Recombinant Sheep IL1B protein, His-tagged E.coli His 114-266aa
Zebrafish IL1B-12106Z Recombinant Zebrafish IL1B Mammalian Cell His
Zebrafish il1b-2298Z Recombinant Zebrafish il1b Protein, His-tagged E.coli N-His Met1-Ile273
Zebrafish il1b-3668Z Recombinant Zebrafish il1b protein, His-tagged E.coli His 41-272aa
Zebrafish il1b-3669Z Recombinant Zebrafish il1b protein, His&Myc-tagged E.coli His&Myc 41-272aa
Pig IL1B-1024P Active Recombinant Pig IL1B Protein E.coli N/A
Pig IL1B-2833P Recombinant Pig IL1B protein, His-tagged E.coli His Val95~Met262
Pig IL1β-82P Recombinant Porcine Interleukin-1 beta E.coli N/A
Pig IL1B-82P Recombinant Pig IL1B protein E.coli N/A 153
Pig IL1B-364I Active Recombinant Pig IL1B Protein (154 aa) E.coli 154
Pig IL1B-163P Recombinant Active Pig IL1B Protein, His-tagged(C-ter) E.coli His(C-ter)
Pig IL1B-205P Active Recombinant Pig IL1B Protein (Ala115-Pro267), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala115-Pro267
Chicken IL1B-6093C Recombinant Chicken IL1B Mammalian Cell His
Chicken IL1B-589C Recombinant Chicken Interleukin 1, Beta E.coli N/A
Chicken IL1B-1021C Recombinant Chicken IL1B Protein, His-tagged E.coli N-His Ser13-Leu242
Chicken IL1B-1782C Recombinant Chicken IL1B protein, His-tagged E.coli His Arg110~Lys263
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL1B Related Articles
  • IL1B Related Research Area

IL1B involved in several pathways and played different roles in them. We selected most pathways IL1B participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPM1BA;RASA1;MKNK1;TGFB3;CDC42L2;PTPRR;TGFBR1B;FGF14;RELA
Cytokine-cytokine receptor interactionTNFRSF12A;CXCR3.2;TNFRSF10D;FLT3;IFNG1-2;TGFBR2;CXCL13;IFNA10;TNFSF14
NF-kappa B signaling pathwayTNFSF14;TNFRSF1A;PTGS2;TNF;BCL2A1;CD40LG;IKBKG;RIPK1;CXCL2
ApoptosisCYCS;CASP6L1;TNFRSFA;RIPK1L;Fasl;OCLN;DYNLL2;PIK3R3B;BIRC8
Osteoclast differentiationcgr2b;FOS;SQSTM1;PIK3R3;IFNG;TNFRSF1A;SIRPB1;FHL2;PIK3CA
Toll-like receptor signaling pathwayMAP2K6;MAP2K4B;TLR1;TLR1LA;PIK3R5;IFNA1;MAPK3;TLR4BA;MAP2K4
NOD-like receptor signaling pathwayCARD9;TRAF6;SUGT1;MAPK8;MAPK1;MAPK14A;NFKBIAB;NAIP6;NFKBIB
Cytosolic DNA-sensing pathwayIL33;IKBKE;POLR3H;POLR1D;IFNB1;IFN-a;NFKBIAB;POLR3E;MAVS
Hematopoietic cell lineageCD1E;ITGB3;GP1BA;GP1BB;CD4;CD34;IL5;Fcer2a;Cd24a
TNF signaling pathwayCCL2;CREB5;TRAF2;Casp3;MAPK1;MAP3K14;AKT1;BIRC2;IL18R1
Inflammatory mediator regulation of TRP channelsNTRK1;PLA2G4F;PIK3R1;CYP2C55;PRKCQ;MAPK10;PLA2G4D;MAPK12;PLCB4
Non-alcoholic fatty liver disease (NAFLD)PIK3CD;NDUFA6;NDUFA5;NDUFS8;SDHB;NDUFB8;PIK3CA;IRS1;NDUFA1
Type I diabetes mellitusHLA-A;HLA-DQA1;H2-AB1;H2-Q10;Fasl;HLA-DOA;CD80;CPE;HLA-DRA
Alzheimers diseaseMAPK3;NDUFB5;TNF;NCSTN;NDUFS1;ATP5J;CALML5;NAE1;NDUFA8
Prion diseasesHc;PRKACB;PRNP;MAPK3;ELK1;C1QB;C9;STIP1;MAP2K1
Salmonella infectionWASF1;ARPC4L;ARPC5A;NOS2;ARPC5B;PYCARD;DYNC1LI1;RAC1;DYNC1LI2
PertussisITGA5;NFKB1;TNF;C4BP;C4BPB;CFL2;IL12B;C1QB;MAPK1
LegionellosisIL-8;VCP;HBS1L;CYCS;SAR1A;NAIP6;MYD88;RAB1;HSF1
LeishmaniasisPRKCB;TNF;TGFB2;HLA-DPB1;TRAF6;NCF1;FCGR4;STAT1;PTGS2
Chagas disease (American trypanosomiasis)IL12A;FOS;FASLG;GNAQ;CD247;PIK3R2;CCL3;Il2;NFKB1
African trypanosomiasisPRKCG;PLCB3;FASLG;TLR9;FAS;HBB-B2;THOP1;PRKCA;PLCB4
MalariaSDC1;HBA2;ITGB2L;THBS4;COMP;TGFB3;ICAM1;GYPC;KLRB1
AmoebiasisCOL1A2;IL10;ADCY1;IL6;C8G;SERPINB13;PIK3R2;PLCB2;VCL
TuberculosisSTAT1;ATP6V0D2;FCGR2B;CASP9;TRAF6;ATP6V0A2;HLA-DQA2;CD74;MAPK11
MeaslesIFNA4;IFNA1;IFIH1;CD209A;IL12A;IL6;RELA;HSPA1B;PIK3CG
Influenza AIFNA5;IRF3;TRIM25;TLR3;TNFSF10;IFNA10;OAS1A;RNASEL;SLC25A6
Herpes simplex infectionCYCSB;PPP1CAB;IRF3;MAPK9;PILRA;IFNA4;SRSF3;OAS3;TAP1
Inflammatory bowel disease (IBD)HLA-DQA1;TLR5;HLA-DQB1;TNF;HLA-DQA2;RORA;IFNG;IL18;IL12B
Rheumatoid arthritisHLA-DRB1;CD80;ATP6V1F;CCL20;ATP6V1C2;ATP6V0A2;ATP6V1G2;Ctsl;IL6
Graft-versus-host diseaseKLRD1;HLA-DRB3;HLA-DRB4;HLA-DRA;HLA-DMB;HLA-DOB;HLA-B;HLA-C;IL6

IL1B has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1B itself. We selected most functions IL1B had, and list some proteins which have the same functions with IL1B. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIFNA14;GDF10;GDF6;TNFRSF11B;Il1f8;IL1B;IL34;IL24;LIF
interleukin-1 receptor bindingIL36A;IRAK4;TRIP6;IL36G;IL1B;IL1A;IRAK1;IL1RN;IL1F10
protein domain specific bindingMED12;KCNN2;ATP1A1;CASP2;HIST1H4B;YWHAQB;SERPINB1A;ARHGEF4;UNC13A

IL1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1B.

IL1RAP; saicar; PKM; IL1R1; A2M; IKBKG; MYC

McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
Leal, RF; Planell, N; et al. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNF alpha therapy. GUT 64:233-242(2015).
  • Q&As
  • Reviews

Q&As (10)

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How does IL-1β initiate inflammasome assembly, and which experimental techniques unravel this intricate process? 07/30/2022

Inflammasome assembly initiated by IL-1β is deciphered using techniques like co-immunoprecipitation, proximity ligation assays, and super-resolution microscopy.

What are the specific mechanisms underlying IL-1β's priming of immune cells, and how can flow cytometry and gene expression analyses decipher these molecular pathways? 07/08/2021

IL-1β's priming of immune cells is dissected through flow cytometry, RNA sequencing, and chromatin immunoprecipitation, revealing its epigenetic and transcriptional effects.

How do post-translational modifications regulate IL-1β's biological activity, and how can mass spectrometry-based phosphoproteomics provide insights into these modifications? 06/06/2020

Mass spectrometry-based phosphoproteomics deciphers IL-1β's post-translational modifications, revealing regulatory sites crucial for its activation and signaling.

How can advanced bioinformatics tools be applied to multi-omics data to comprehensively understand the intricate roles of IL-1β in health and disease? 04/16/2020

Bioinformatics tools integrate multi-omics data to provide a comprehensive understanding of IL-1β's roles, revealing its intricate contributions to health and disease.

What is the significance of IL-1β's epigenetic regulation in chronic inflammatory diseases, and how can ChIP-seq and DNA methylation profiling uncover these regulatory elements? 11/01/2019

ChIP-seq and DNA methylation profiling uncover IL-1β's epigenetic impact on target genes, shedding light on its role in shaping chronic inflammatory states.

How does IL-1β interact with its downstream effectors to induce the production of pro-inflammatory cytokines, and how can dual-luciferase reporter assays reveal these intricate interactions? 03/31/2019

IL-1β's interactions with downstream effectors are unveiled using dual-luciferase reporter assays, surface plasmon resonance, and co-crystallization studies.

What are the complex feedback loops between IL-1β and other cytokines, and how can systems biology approaches like network analysis dissect these dynamic interactions? 01/24/2019

Network analysis integrates omics data to unravel IL-1β's intricate cross-talk with other cytokines, mapping out complex regulatory loops in inflammation.

What is the role of IL-1β in modulating the tumor microenvironment, and how can advanced imaging techniques like intravital microscopy elucidate its impact on immune cell dynamics? 08/08/2017

IL-1β's impact on the tumor microenvironment is studied using intravital microscopy, 3D culture models, and single-cell RNA sequencing to capture dynamic cell behavior.

What are the mechanisms underlying IL-1β's non-canonical signaling pathways, and how can CRISPR-Cas9 screening identify key mediators of these alternative pathways? 04/18/2017

CRISPR-Cas9 screening identifies IL-1β's non-canonical signaling mediators through functional genomics, revealing alternative pathways in cellular responses.

How does IL-1β's signaling adapt to different cellular contexts, and how can single-cell RNA sequencing uncover cell-specific responses to this cytokine? 01/03/2017

Single-cell RNA sequencing unveils IL-1β's context-specific responses, exposing cell type-specific signaling and gene expression patterns.

Customer Reviews (3)

Write a review
Reviews
11/08/2021

    Effective in inflammation studies.

    04/23/2021

      High specificity.

      06/30/2020

        Suitable for cytokine assays.

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