ILKAP
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Official Full Name
integrin-linked kinase-associated serine/threonine phosphatase
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Overview
The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. -
Synonyms
ILKAP; integrin-linked kinase-associated serine/threonine phosphatase; integrin linked kinase associated serine/threonine phosphatase 2C; integrin-linked kinase-associated serine/threonine phosphatase 2C; DKFZP434J2031; FLJ10181; protein phosphatase 2c, d;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ILKAP Related Articles
- ILKAP Related Research Area
ILKAP involved in several pathways and played different roles in them. We selected most pathways ILKAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ILKAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ILKAP has several biochemical functions, for example, metal ion binding, protein binding, protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ILKAP itself. We selected most functions ILKAP had, and list some proteins which have the same functions with ILKAP. You can find most of the proteins on our site.
Function | Related Protein |
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metal ion binding | ZFP458;TANK;ZNF74;ZNF615;TRIM35-31;PAPOLG;JMJD5;ZNF718;SAP30 |
protein binding | RPF1;ARFIP2;KLHDC3;Raet1c;CCDC88A;FTL;HENMT1;HIP1;BAP1 |
protein serine/threonine phosphatase activity | CDC14C;PPP5C;MTMR3;PPM1A;LCK;CTDNEP1A;TAB1;PPP1CC;DULLARD |
ILKAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILKAP here. Most of them are supplied by our site. Hope this information will be useful for your research of ILKAP.
ILK; pi3p; 15-deoxy-delta(12,14; LTN1; STAT5A; C21orf59; PDK1; CHST15; Wdr48; FBXO18; CERK
- Q&As
- Reviews
Q&As (6)
Ask a questionILKAP is a serine/threonine protein phosphatase that is intracellular localized in the cytoplasm and cytoskeleton and interacts with Integrin-linked kinase (ILK).
It has been shown that ILKAP may interact with NF-κB and JAK/STAT signaling pathways, but further studies are needed to clarify the specific role and mechanism.
ILKAP may be involved in the process of immune regulation and affect the activity and response of immune cells, but the specific role needs to be further studied.
Some studies have shown that ILKAP expression level decreased in some tumors may be associated with poor prognosis of tumour, but the specific mechanism still need more study.
Several studies have suggested that ILKAP may play a role in apoptosis, thereby affecting cell survival and proliferation.
The interaction between ILKAP and ILK, and may be involved in cell adhesion, movement and biological processes such as signal transmission.
Customer Reviews (3)
Write a reviewNo doping impurities, the experimental results are very good, will recommend to other students.
The sensitivity is very high, the experimental results are very good, and the unnecessary trouble is reduced.
Not easy to inactivate, tried a variety of experimental conditions, still active.
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