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ILKAP

  • Official Full Name

    integrin-linked kinase-associated serine/threonine phosphatase

  • Overview

    The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.
  • Synonyms

    ILKAP; integrin-linked kinase-associated serine/threonine phosphatase; integrin linked kinase associated serine/threonine phosphatase 2C; integrin-linked kinase-associated serine/threonine phosphatase 2C; DKFZP434J2031; FLJ10181; protein phosphatase 2c, d;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ILKAP-1126H Recombinant Human ILKAP, His tagged Human Cell His
Human ILKAP-14217H Recombinant Human ILKAP, His-tagged E.coli His 1-392a.a.
Human ILKAP-1855HCL Recombinant Human ILKAP cell lysate Human Cell N/A
Human ILKAP-3111H Recombinant Human ILKAP protein, His-SUMO-tagged E.coli His-SUMO 1-392aa
Human ILKAP-2174H Recombinant Human ILKAP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ILKAP-5156H Recombinant Human ILKAP Protein, GST-tagged Wheat Germ GST
Human ILKAP-5797HF Recombinant Full Length Human ILKAP Protein, GST-tagged In Vitro Cell Free System GST 392 amino acids
Human ILKAP-1677H Recombinant Human ILKAP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse ILKAP-8188M Recombinant Mouse ILKAP Protein Mammalian Cell His
Mouse ILKAP-4526M Recombinant Mouse ILKAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ilkap-3526M Recombinant Mouse Ilkap Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ILKAP-4526M-B Recombinant Mouse ILKAP Protein Pre-coupled Magnetic Beads HEK293
Rat ILKAP-3053R Recombinant Rat ILKAP Protein Mammalian Cell His
Rat ILKAP-2709R Recombinant Rat ILKAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ILKAP-2709R-B Recombinant Rat ILKAP Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ILKAP Related Articles
  • ILKAP Related Research Area

ILKAP involved in several pathways and played different roles in them. We selected most pathways ILKAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ILKAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ILKAP has several biochemical functions, for example, metal ion binding, protein binding, protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ILKAP itself. We selected most functions ILKAP had, and list some proteins which have the same functions with ILKAP. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZFP458;TANK;ZNF74;ZNF615;TRIM35-31;PAPOLG;JMJD5;ZNF718;SAP30
protein bindingRPF1;ARFIP2;KLHDC3;Raet1c;CCDC88A;FTL;HENMT1;HIP1;BAP1
protein serine/threonine phosphatase activityCDC14C;PPP5C;MTMR3;PPM1A;LCK;CTDNEP1A;TAB1;PPP1CC;DULLARD

ILKAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILKAP here. Most of them are supplied by our site. Hope this information will be useful for your research of ILKAP.

ILK; pi3p; 15-deoxy-delta(12,14; LTN1; STAT5A; C21orf59; PDK1; CHST15; Wdr48; FBXO18; CERK

Arroyo-Berdugo, Y; Alonso, S; et al. Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma. PLOS ONE 9:-(2014).
Zhou, W; Cao, H; et al. Characterization of Nuclear Localization Signal in the N Terminus of Integrin-linked Kinase-associated Phosphatase (ILKAP) and Its Essential Role in the Down-regulation of RSK2 Protein Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 288:6259-6271(2013).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the function of ILKAP? What is the localization inside the cell? 10/02/2019

ILKAP is a serine/threonine protein phosphatase that is intracellular localized in the cytoplasm and cytoskeleton and interacts with Integrin-linked kinase (ILK).

Which signaling pathways are involved in ILKAP? 08/19/2019

It has been shown that ILKAP may interact with NF-κB and JAK/STAT signaling pathways, but further studies are needed to clarify the specific role and mechanism.

How does ILKAP play a role in immune regulation? 08/06/2019

ILKAP may be involved in the process of immune regulation and affect the activity and response of immune cells, but the specific role needs to be further studied.

Is ILKAP expression level correlated with tumor prognosis? 05/08/2019

Some studies have shown that ILKAP expression level decreased in some tumors may be associated with poor prognosis of tumour, but the specific mechanism still need more study.

What is the role of ILKAP in apoptosis? 04/19/2019

Several studies have suggested that ILKAP may play a role in apoptosis, thereby affecting cell survival and proliferation.

How do ILKAP and ILK interact with each other? 03/17/2019

The interaction between ILKAP and ILK, and may be involved in cell adhesion, movement and biological processes such as signal transmission.

Customer Reviews (3)

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Reviews
11/04/2022

    No doping impurities, the experimental results are very good, will recommend to other students.

    05/26/2022

      The sensitivity is very high, the experimental results are very good, and the unnecessary trouble is reduced.

      09/30/2021

        Not easy to inactivate, tried a variety of experimental conditions, still active.

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