IMPA1
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Official Full Name
inositol(myo)-1(or 4)-monophosphatase 1
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Overview
This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009] -
Synonyms
IMPA1; inositol(myo)-1(or 4)-monophosphatase 1; IMP; IMPA; inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- IMPA1 Related Articles
- IMPA1 Related Research Area
IMPA1 involved in several pathways and played different roles in them. We selected most pathways IMPA1 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PLCZ1;MTMR8;MTMR4;SYNJ2;MINPP1B;PIP4K2A;NUDT3B;PIKFYVE;INPP4A |
| Metabolic pathways | POLR2H;NDUFB1;MAT2A;PLCB1;ATP6V0B;DEGS2;PFAS;GALE;ALG14 |
| Phosphatidylinositol signaling system | CALM2;PIK3R5;CALM3A;SYNJ1;PRKCBB;CALM;PPIP5K1;PIK3R2;IP6K1 |
IMPA1 has several biochemical functions, for example, identical protein binding, inositol monophosphate 1-phosphatase activity, inositol monophosphate 3-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA1 itself. We selected most functions IMPA1 had, and list some proteins which have the same functions with IMPA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | PICK1;MAP1S;LCK;GM5077;NFKBIA;TOPBP1;BIRC5;NOL3;DIAPH1 |
| inositol monophosphate 1-phosphatase activity | IMPA1;IMPA2;IMPAD1 |
| inositol monophosphate 3-phosphatase activity | IMPA2;IMPA1;IMPAD1 |
| inositol monophosphate 4-phosphatase activity | IMPAD1;IMPA1;IMPA2 |
| inositol monophosphate phosphatase activity | |
| lithium ion binding | IMPA1;PDXK |
| magnesium ion binding | DYRK2;OPA1;PPM1AB;ZAK;NT5C1A;HPRT1L;PAPOLA;NT5C1AA;IMPA2 |
| manganese ion binding | TDP2B;PPEF1;DCP2;FAM20C;WRN;TDP2;ABL1;FEN1;ATP2C1 |
| protein binding | EIF4EBP1;CCDC22;OFD1;HFE;ALKBH4;CDC42EP1;TFF3;CDK2;BRD9 |
| protein homodimerization activity | TBC1D22A;SYNDIG1;XPNPEP1;SQSTM1;GOT2;CHRNA7;ANXA1;HMOX1;PVRL2L |
IMPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA1.
IMPA2; Impa1; E2F3
- Q&As
- Reviews
Q&As (6)
Ask a questionThis protein in the treatment of schizophrenia, bipolar disorder and mental disorders such as autism and muscle disease and potential application in organ transplantation.
This protein plays an important role in autism by regulating the glutamate signaling pathway and neuronal activity, affecting the development of the disease and the performance of social interaction.
It can regulate phosphocreatine cycle and energy metabolism, and is associated with muscle diseases such as myasthenia and muscular atrophy.
IMPA1 can regulate folate metabolism pathway and TH1/TH2 immune balance, and participate in the immune regulation of organ transplantation and the control of inflammatory response in vivo.
It plays an important role in schizophrenia, which can regulate the glutamate signaling pathway and the level of creatine in the brain, and affect the development of the disease and the performance of symptoms.
This plays an important role in bipolar disorder, which can regulate the creatine cycle and glutamate signaling pathway, and affect the development of the disease and the stability of neurons.
Customer Reviews (3)
Write a reviewIt has good stability in different environments, and has thermal stability and acid-base stability.
The storage method is simple and no special environment is required.
In the experiment, the effect is remarkable, and it has strong stability.
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