IMPA2
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Official Full Name
inositol(myo)-1(or 4)-monophosphatase 2
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Overview
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011] -
Synonyms
IMPA2; inositol(myo)-1(or 4)-monophosphatase 2; inositol monophosphatase 2; IMP 2; IMPase 2; inosine monophosphatase 2; myo-inositol monophosphatase A2; inositol monophosphatase 2 variant 1; inositol monophosphatase 2 variant 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- IMPA2 Related Articles
IMPA2 involved in several pathways and played different roles in them. We selected most pathways IMPA2 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PLCG2;MTMR4;NUDT3B;MTMR7A;IP6K3;PIP5K1C;MTM1;PIK3C2B;PIKFYVE |
| Metabolic pathways | ATP6V1A;UROD;UGT1A4;PPCDC;ALAS1;SLC27A5;COX7C;MTMR7A;PRODH |
| Phosphatidylinositol signaling system | PLCD1B;CALM1B;PIK3C3;PTENB;PIP5K1BB;INPP5K;PRKCA;MTMR2;PIK3CD |
IMPA2 has several biochemical functions, for example, inositol monophosphate 1-phosphatase activity, inositol monophosphate 3-phosphatase activity, inositol monophosphate 4-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPA2 itself. We selected most functions IMPA2 had, and list some proteins which have the same functions with IMPA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol monophosphate 1-phosphatase activity | IMPA1;IMPAD1;IMPA2 |
| inositol monophosphate 3-phosphatase activity | IMPA1;IMPA2;IMPAD1 |
| inositol monophosphate 4-phosphatase activity | IMPA1;IMPAD1;IMPA2 |
| magnesium ion binding | RNASEH1;DCTPP1;ADPRH;PPA1;HPRT1;CLYBL;ENDOV;TREX2;NT5C1BA |
| protein binding | SULT1B1;LMX1A;SMAD5;AGTR1A;MYL12A;PSMC1;TRMT112;NOP2;DSCC1 |
| protein homodimerization activity | PLD6;NAMPT;FBXO4;GPD1A;CHMP1A;HSD17B4;EPHX2;VPS4B;DMRT1 |
IMPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPA2.
IMPA1; UBA3; CCT6A; HERPUD1; q8ckm5_yerpe; TNFRSF14
- Q&As
- Reviews
Q&As (6)
Ask a questionIMPA2, short for Inositol monophosphatase 2, is the gene encoding the related enzyme. It is widely expressed in the human body, but the specific expression pattern may vary among tissues and organs.
The association between IMPA2 and neurodegenerative diseases may be related to its role in the intracellular inositol metabolic pathway. More research is needed to advance our understanding of this association.
No drugs have been identified that directly regulate IMPA2 activity. However, there are other ways to regulate the intracellular inositol metabolic pathway to affect the function of IMPA2.
Several studies have suggested that IMPA2 may be associated with psychiatric disorders such as bipolar disorder and schizophrenia, as well as neurological disorders such as degenerative neurological disorders and neurodysplasia.
It is involved in the intracellular inositol metabolic pathway, which is one of the key biological processes for intracellular signaling and neurotransmitter synthesis.
IMPA2 may be involved in physiological mechanisms related to neurotransmitter synthesis and neurotransmission in psychiatric disorders. The specific mechanism and regulation mode need to be further studied.
Customer Reviews (3)
Write a reviewPurity and biological activity are very good, which makes its products have extremely high reliability.
After using this recombinant protein, my experiment repeatability is very good, which is convenient for subsequent data analysis and experimental operation.
The background in the Western blot was very clean and showed good antibody specificity.
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