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IMPDH1

  • Official Full Name

    IMP (inosine 5-monophosphate) dehydrogenase 1

  • Overview

    The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
  • Synonyms

    IMPDH1; IMP (inosine 5-monophosphate) dehydrogenase 1; IMPD; RP10; IMPD1; LCA11; sWSS2608; inosine-5-monophosphate dehydrogenase 1; IMPD 1; IMPDH 1; IMPDH-I; IMP dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf21 insect cells
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IMPDH1-01H Active Recombinant Human IMPDH1 Protein, His-Tagged Sf21 insect cells His
Human IMPDH1-2580H Recombinant Human IMPDH1, His-tagged E.coli His
Human IMPDH1-28268TH Recombinant Human IMPDH1, His-tagged E.coli His 514 amino acids
Human IMPDH1-5211HCL Recombinant Human IMPDH1 293 Cell Lysate HEK293 N/A
Human IMPDH1-5212HCL Recombinant Human IMPDH1 293 Cell Lysate HEK293 N/A
Human IMPDH1-5140H Recombinant Human IMPDH1 Protein, GST-tagged Wheat Germ GST
Human IMPDH1-5865HF Recombinant Full Length Human IMPDH1 Protein, GST-tagged In Vitro Cell Free System GST 563 amino acids
Human IMPDH1-4548H Recombinant Human IMPDH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IMPDH1-280H Recombinant Human IMPDH1 protein, His-tagged E. coli His 170-235 aa
Mouse IMPDH1-8198M Recombinant Mouse IMPDH1 Protein Mammalian Cell His
Mouse IMPDH1-4534M Recombinant Mouse IMPDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Impdh1-3531M Recombinant Mouse Impdh1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse IMPDH1-4534M-B Recombinant Mouse IMPDH1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

IMPDH1 involved in several pathways and played different roles in them. We selected most pathways IMPDH1 participated on our site, such as Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLE4;POLE;Adcy4;POLA2;ADSS;NPR1;PRPS1B;AK7B;TWISTNB
Drug metabolism - other enzymesUCK2A;IMPDH1A;DPYS;IMPDH1;UGT1A3;TPMT.1;CES1C;UGT1A6;DPYDB
Metabolic pathwaysGCNT3;CMASA;B4GALT7;ADK;MSMO1;GCDH;PLCZ1;POLR2B;PLA2G12A

IMPDH1 has several biochemical functions, for example, DNA binding, IMP dehydrogenase activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPDH1 itself. We selected most functions IMPDH1 had, and list some proteins which have the same functions with IMPDH1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingASXL2;ZBTB7A;NFYA;HIST1H2A9;ZNF789;FOXC1B;NFE2L2;GM14478;CHST13
IMP dehydrogenase activityIMPDH1A;IMPDH1B;IMPDH2;IMPDH1
RNA bindingWDHD1;IFIT10;TTC6;THUMPD3;IFIT1;HNRNPAB;DDX11;NR0B1;HNRPK
metal ion bindingITPK1A;MUS81;ZBTB2A;ZNF606;UQCRC2A;JADE3;MAP3K15;TGM2A;ZFP768
nucleic acid bindingZNF45L;ZFP385C;AEN;ZNRD1;ZBTB46;BHLHE22;MARF1;SETD1BA;SFRS3B

IMPDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPDH1.

GMNN; q7cfv5_yerpe; HTRA1; MYO1C; SEC16A; XRCC3; Junb; Lgals3bp; EMC2; Rpl35; MMGT1

  • Q&As
  • Reviews

Q&As (6)

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In which tissues or organs is IMPDH1 expressed? 12/13/2019

It is expressed in a wide range of tissues and organs, including liver, kidney, heart, muscle and immune system, among others.

What role does IMPDH1 play in immune regulation? 12/13/2019

This is involved in the regulation of purine metabolism in immune cells, affecting T cell activation and immune cell function.

What is the role of IMPDH1 in tumors? 12/02/2019

It is highly expressed in tumor cells. It is involved in the regulation of purine metabolism and nucleic acid synthesis, and plays an important role in cell proliferation and survival.

Are mutations in IMPDH1 associated with drug resistance? 10/10/2019

IMPDH1 mutations may be associated with some drug resistance, because IMPDH1 is a key enzyme in purine nucleotide synthesis and plays an important role in drug treatment.

Does IMPDH1 interact with signaling pathways or molecules? 07/06/2019

The interacts with molecules such as mTOR signaling pathway, GTpase-activating proteins and uric acid.

Are IMPDH1 mutations associated with inherited diseases? 07/05/2019

Mutations in IMPDH1 can cause genetic diseases such as carnivorous syphilis, immune-related diseases and neurological disorders.

Customer Reviews (3)

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Reviews
02/15/2020

    The operation method is very simple, and accurate experimental results can be obtained easily.

    04/25/2019

      Strong anti-pollution ability, not easy to pollute, to ensure the accuracy of the experiment.

      04/12/2019

        High sensitivity, small amount can successfully complete the experiment.

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