INADL
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Official Full Name
InaD-like (Drosophila)
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Overview
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. -
Synonyms
INADL; InaD-like (Drosophila); inaD-like protein; Cipp; PATJ; Channel interacting PDZ domain protein; FLJ26982; hINADL; Inactivation no after potential D like protein; INAD like; InaD like Drosophila; INAD like protein; INADL protein; PALS 1 associated tight junction protein; PALS1 associated tight junction protein; PDZ domain protein; PDZ domain protein Drosophila inaD like; Post synaptic density 95 / discs large / zonula occludens 1 domain protein; Protein associated to tight junctions; channel-interacting PDZ domain protein; PALS1-associated tight junction protein; inactivation no after-potential D-like protein; InaD-like;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | INADL-108H | Recombinant Human INADL, His-tagged | E.coli | His | 737-1079aa | |
| Human | INADL-5136H | Recombinant Human INADL Protein, GST-tagged | Wheat Germ | GST |
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| Mouse | INADL-8203M | Recombinant Mouse INADL Protein | Mammalian Cell | His |
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| Mouse | INADL-4539M-B | Recombinant Mouse INADL Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | INADL-4539M | Recombinant Mouse INADL Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Zebrafish | INADL-6771Z | Recombinant Zebrafish INADL | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
INADL involved in several pathways and played different roles in them. We selected most pathways INADL participated on our site, such as Cell junction organization, Cell-Cell communication, Cell-cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with INADL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell junction organization | CDH3;CDH6;DST;ITGB1B.1;CLDN16;JUP;CDH8;LIMS1;CD151 |
| Cell-Cell communication | F11R.2;CDH2;CDH11;CDH17;CLDN16;CDH5;DSCAM;CDH24;PVRL1A |
| Cell-cell junction organization | CDH11;CDH24;CDH8;CDH10;CDH3;CDH17;JUP;ANG;CADM2B |
| Hippo signaling pathway | BMP6;WNT8B;WNT5A;SAV1;TGFBR1;BMPR1A;PRKCI;TGFB2;MPP5 |
| Tight junction | CLDN20;CLDN16;PPP2R2BB;ZAK;MYL12.1;ACTN1;TJP2;CLDN7A;PPP2R1A |
| Tight junction interactions | CLDN20;CLDN3;CLDN4;INADL;CLDN16;CLDN23;CLDN7 |
INADL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INADL itself. We selected most functions INADL had, and list some proteins which have the same functions with INADL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LCE4A;POLR2A;HNRNPM;GAL;IRS2;HIST1H2BB;NEURL1B;F8;MYC |
INADL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INADL here. Most of them are supplied by our site. Hope this information will be useful for your research of INADL.
MPP5; YAP1; TJP3; CRB1; NF2; F2RL2; AMOT
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, the INADL protein is related to the central cone connection of retinal cells and can promote the organization establishment and stabilization of the central cone.
The mechanism by which INADL proteins are involved in regulating cell migration and invasion is still unclear and needs to be confirmed by further studies.
Yes. Some studies have shown that INADL may be associated with Parkinson's disease. This, however, further studies are needed to determine its function and molecular mechanism of concrete.
Yes, INADL interact with multiple proteins, such as protein PKA, TRP and salt bridge. These effects help regulate the conduction of signaling pathways and the maintenance of cell polarity.
Yes, several studies have suggested that INADL may be involved in auditory signal transduction and the onset and progression of deafness.
There is no report about INADL mutations can lead to human disease, but there are some studies have shown that INADL may play a role in some neurological diseases.
Customer Reviews (3)
Write a reviewHigh safety, high expression level, ideal for laboratory and practical applications.
Qualitative is very strong, even after a lot of use can still maintain its structural and functional stability, which shows its excellent quality and reliability.
The anti-interference ability in Western blot is very strong, which can effectively resist the influence of endogenous interference factors.
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