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ING4

  • Official Full Name

    inhibitor of growth family, member 4

  • Overview

    This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
  • Synonyms

    ING4; inhibitor of growth family, member 4; inhibitor of growth protein 4; my036; p29ING4; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; MGC12557;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc|His
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ING4-455H Recombinant Human ING4, His tagged E.coli Fc/His
Human ING4-113H Recombinant Human ING4 protein(Met1-Lys249), His-tagged E. coli N-His Met1-Lys249
Human ING4-5206HCL Recombinant Human ING4 293 Cell Lysate HEK293 N/A
Human ING4-4127H Recombinant Human ING4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ING4-5126H Recombinant Human ING4 Protein, GST-tagged Wheat Germ GST
Human ING4-5878HF Recombinant Full Length Human ING4 Protein, GST-tagged In Vitro Cell Free System GST 249 amino acids
Human ING4-2717H Recombinant Human ING4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ING4-1670HFL Recombinant Full Length Human ING4 Protein, C-Flag-tagged Mammalian cells Flag
Human ING4-1183H Recombinant Human ING4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ING4-1183H-B Recombinant Human ING4 Protein Pre-coupled Magnetic Beads HEK293
Mouse ING4-8210M Recombinant Mouse ING4 Protein Mammalian Cell His
Mouse ING4-4545M-B Recombinant Mouse ING4 Protein Pre-coupled Magnetic Beads HEK293
Mouse ING4-4545M Recombinant Mouse ING4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ING4-2674Z Recombinant Zebrafish ING4 Mammalian Cell His
Chicken ING4-1398C Recombinant Chicken ING4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ING4 Related Articles

ING4 involved in several pathways and played different roles in them. We selected most pathways ING4 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesKANSL3;SUZ12A;MBD3B;EHMT2;YEATS4;TADA1;TADA3;SAP30L;MSL2A
Chromatin organizationKDM5A;BRPF3;KDM4B;GATAD2AB;SAP30L;DPY30;PRMT7;DR1;DNMT3A
HATs acetylate histonesEPC1;EP400;TADA2A;C3orf75;ATXN7L3;JADE1;RBB4L;PAX3A;ELP2

ING4 has several biochemical functions, for example, methylated histone binding, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ING4 itself. We selected most functions ING4 had, and list some proteins which have the same functions with ING4. You can find most of the proteins on our site.

Function Related Protein
methylated histone bindingCHD8;CBX5;WDR92;MTF2;MSL3;CDYL2;SUZ12;CCDC101;ING1
protein bindingPRKAA1;MRPL20;BATF2;HEYL;ELP4;SEMG2;PFN2;CCND2;NSG1
transcription coactivator activityPOU2AF1;KLF7;WWC1;TFAP2A;NR5A1;TADA2A;SUB1A;PQBP1;PARK7
zinc ion bindingZCCHC9;APOBEC2B;PAPLNB;ADAM15;MEP1A;BTR12;ADAM9;ZNF638;CAR6

ING4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING4.

HNRNPD; NAV2; HIST1H3D; HNRNPD; HNRNPD; HNRNPD; HNRNPD

Byron, SA; Min, E; et al. Negative Regulation of NF-kappa B by the ING4 Tumor Suppressor in Breast Cancer. PLOS ONE 7:-(2012).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the molecular weight of the ING4 protein? 07/24/2021

The molecular weight of ING4 is approximately 36 kDa.

What is the subcellular localization of ING4? 12/02/2019

ING4 is mainly found in the nucleus of cells.

Which gene encodes the ING4 protein? 07/15/2019

The ING4 protein is encoded by the ING4 gene.

Are there any known mutations in the ING4 gene linked to disease? 03/20/2019

Yes, mutations in the ING4 gene have been associated with certain cancers.

What is the function of ING4 in cells? 03/19/2019

ING4 is involved in regulating cell growth, apoptosis, and DNA repair.

What is the full name of the ING4 protein? 09/21/2017

ING4 stands for “Inhibitor of Growth 4

Is ING4 associated with cancer? 08/27/2016

Yes, ING4 is considered a tumor suppressor and its loss of function can contribute to cancer development.

Customer Reviews (3)

Write a review
Reviews
06/02/2022

    Comprehensive documentation streamlined the integration of the product into our experimental workflow.

    07/17/2021

      Replicating results underscored the reliability and relevance of the product's effects.

      08/27/2019

        Minimal background noise in our assays was indicative of the product's superior quality.

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