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INMT

  • Official Full Name

    indolethylamine N-methyltransferase

  • Overview

    N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene.
  • Synonyms

    INMT; indolethylamine N-methyltransferase; Amine N methyltransferase; Amine N-methyltransferase; Aromatic alkylamine N methyltransferase; Aromatic alkylamine N-methyltransferase; Arylamine N methyltransferase; Arylamine N-methyltransferase; Indolamine N-methyltransferase; Indolethylamine N methyltransferase; INMT_HUMAN; nicotine N methyltransferase; thioester S methyltransferase like; nicotine N-methyltransferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INMT-115H Recombinant Human INMT, GST-tagged E.coli GST C-198aa
Human INMT-347HCL Recombinant Human INMT lysate HEK293 N/A
Human INMT-5114H Recombinant Human INMT Protein, GST-tagged Wheat Germ GST
Human INMT-1184H Recombinant Human INMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human INMT-2400H Recombinant Human INMT Protein, His-tagged E.coli His
Human INMT-2399H Recombinant Human INMT Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human INMT-3771H Recombinant Human INMT protein, GST-tagged E.coli GST 67-263 aa
Human INMT-6553H Recombinant Human INMT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human INMT-584H Recombinant Human INMT Protein (1-263 aa), His-SUMO-tagged E.coli His/SUMO 1-263 aa
Human INMT-1894HFL Recombinant Full Length Human INMT Protein, C-Flag-tagged Mammalian cells Flag
Human INMT-1184H-B Recombinant Human INMT Protein Pre-coupled Magnetic Beads HEK293
Mouse INMT-8217M Recombinant Mouse INMT Protein Mammalian Cell His
Mouse INMT-4551M Recombinant Mouse INMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Inmt-3541M Recombinant Mouse Inmt Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse INMT-4551M-B Recombinant Mouse INMT Protein Pre-coupled Magnetic Beads HEK293
Rat INMT-104R Recombinant Rat INMT Protein, His-tagged E.coli His
Rabbit INMT-99R Recombinant Rabbit INMT Protein, His-tagged E.coli His
Rhesus Macaque INMT-2272R Recombinant Rhesus monkey INMT Protein, His-tagged Mammalian Cell His
Rhesus Macaque INMT-2093R-B Recombinant Rhesus Macaque INMT Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque INMT-2093R Recombinant Rhesus Macaque INMT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • INMT Related Articles

INMT involved in several pathways and played different roles in them. We selected most pathways INMT participated on our site, such as Selenocompound metabolism, Tryptophan metabolism, nicotine degradation IV, which may be useful for your reference. Also, other proteins which involved in the same pathway with INMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Selenocompound metabolismMTR;CCBL2;TRR1;TXNRD3;TXNRD1;SEPSECS;TXNRD2;PSTK;SPS2
Tryptophan metabolismOGDH;TPH1;CCBL2;CYP1A;CYP4F12;AOX2P;TDO2;CMTM2A;ACAT1
nicotine degradation IV

INMT has several biochemical functions, for example, amine N-methyltransferase activity, protein binding, thioether S-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INMT itself. We selected most functions INMT had, and list some proteins which have the same functions with INMT. You can find most of the proteins on our site.

Function Related Protein
amine N-methyltransferase activity
protein bindingMED10;EDNRA;MEAF6;SSX2;CD36;SPATC1;SNX17;USP19;RNF6
thioether S-methyltransferase activity

INMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INMT here. Most of them are supplied by our site. Hope this information will be useful for your research of INMT.

KLHL12

Bashiri, A; Heo, HJ; et al. Pregnancy complicated by obesity induces global transcript expression alterations in visceral and subcutaneous fat. MOLECULAR GENETICS AND GENOMICS 289:695-705(2014).
Chu, UB; Vorperian, SK; et al. Noncompetitive Inhibition of Indolethylamine-N-methyltransferase by N,N-Dimethyltryptannine and N,N-Dimethylaminopropyltryptamine. BIOCHEMISTRY 53:2956-2965(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the molecular function of INMT? 10/11/2022

INMT is classified as a methyltransferase and functions as a transferase enzyme.

Why is the N-methylation of tryptamine and related compounds significant? 09/07/2020

This reaction has relevance in various biochemical and physiological processes.

What is the specific enzymatic reaction catalyzed by INMT? 06/02/2020

INMT catalyzes the N-methylation of tryptamine and structurally related compounds.

What is the primary function of INMT in terms of chemical reactions? 07/05/2018

It functions as a thioether S-methyltransferase, acting on various thioethers and related selenium and tellurium compounds.

What is the full name of the INMT protein? 07/26/2017

Indolethylamine N-methyltransferase.

What role does INMT play in the detoxification of selenium compounds? 06/20/2017

INMT is involved in the detoxification of selenium compounds.

Can you provide examples of the compounds INMT is active with? 05/30/2017

INMT is active with compounds like 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide, and diethyl sulfide.

Customer Reviews (3)

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Reviews
01/28/2020

    The product's customizability allowed us to fine-tune experiments to match our specific research objectives.

    06/28/2018

      The product's versatility allowed us to apply it to a wide range of experimental techniques and research areas.

      01/26/2016

        We appreciated the product's efforts to minimize its environmental footprint through sustainable manufacturing practices.

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