INPP5A
-
Official Full Name
inositol polyphosphate-5-phosphatase, 40kDa
-
Overview
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. -
Synonyms
INPP5A; inositol polyphosphate-5-phosphatase, 40kDa; inositol polyphosphate 5 phosphatase, 40kD; type I inositol-1,4,5-trisphosphate 5-phosphatase; 5PTASE; 43 kDa inositol polyphosphate 5 phophatase; CTCL tumor antigen HD CL 02; inositol polyphosphate 5 phophatase; 40kDa; InsP3 5 phosphatase; type I inositol 1; 4; 5 trisphosphate 5 phosphatase; 43 kDa inositol polyphosphate 5-phophatase; 5-trisphosphate 5-phosphatase; CTCL tumor antigen HD-CL-02; DKFZp434A1721; I5P1; I5P1_HUMAN; Inositol polyphosphate 5 phosphatase; inositol polyphosphate-5-phosphatase A; inositol trisphosphate-5-phosphatase; INPP5A inositol polyphosphate-5-phosphatase; InsP3 5-phosphatase; MGC116947; MGC116949; Type I inositol-1; type I inositol-1,4,5-trisphosphate 5-phophatase; OTTHUMP00000020775; OTTHUMP00000020776; OTTHUMP00000020777; inositol trisphosphate-5-phosphatase, 40kD; type I inosito;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His|SUMO
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | INPP5A-27622TH | Recombinant Human INPP5A | Wheat Germ | N/A | 100 amino acids |
|
| Human | INPP5A-5199HCL | Recombinant Human INPP5A 293 Cell Lysate | HEK293 | N/A |
|
|
| Human | INPP5A-5108H | Recombinant Human INPP5A Protein, GST-tagged | Wheat Germ | GST |
|
|
| Human | INPP5A-1012H | Recombinant Human INPP5A Protein (1-409 aa), His-SUMO-tagged | E.coli | His/SUMO | 1-409 aa |
|
| Human | INPP5A-3623H | Recombinant Human INPP5A Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
|
|
| Human | INPP5A-3375H | Recombinant Human INPP5A Protein (Met1-Val410), C-His tagged | Mammalian cells | C-His | Met1-Val410 |
|
| Human | INPP5A-012H | Recombinant Human INPP5A Protien, His-tagged | E. coli | His | 99-412 aa | |
| Human | INPP5A-5953HF | Recombinant Full Length Human INPP5A Protein, GST-tagged | In Vitro Cell Free System | GST | 412 amino acids |
|
| Human | INPP5A-013H | Recombinant Human INPP5A Protein, His-tagged | HEK293 | His | Met1-Val410 |
|
| Mouse | Inpp5a-3546M | Recombinant Mouse Inpp5a Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
|
- Involved Pathway
- Protein Function
- Interacting Protein
- INPP5A Related Articles
INPP5A involved in several pathways and played different roles in them. We selected most pathways INPP5A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PTEN;PLCB4;PI4K2B;ITPK1;INPP1;INPP5A;INPP5K;MTMR7B;PLCD1A |
| Metabolic pathways | ATP6V0A1B;PTGESL;AGLA;CHIA.3;CSGALNACT1;AOX2P;FUT6;FH1;mt-Atp8 |
| Phosphatidylinositol signaling system | PIP5K2;PRKCG;CALM4;INPPL1A;PTENB;PI4KAA;MTMR2;INPP4B;PIK3CD |
INPP5A has several biochemical functions, for example, PH domain binding, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5A itself. We selected most functions INPP5A had, and list some proteins which have the same functions with INPP5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PH domain binding | EPB41L2;INPP5A;EPHA4 |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | INPP5K;INPP5J;INPP5A |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | INPP5A;INPP5B;INPP5J;INPP5K |
| inositol-polyphosphate 5-phosphatase activity | INPP5J;INPP5K;INPP5E;INPP5A;INPPL1;INPP5D |
| protein binding | DGCR6L;DGKQ;DDX3X;DUSP21;VIPAS39;GAB3;SKAP2;BLOC1S5;TEAD1 |
INPP5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5A here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5A.
PLEK
- Q&As
- Reviews
Q&As (7)
Ask a questionAccording to Entrez, the protein encoded by INPP5A is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase.
INPP5A plays a crucial role in the survival of cerebellar Purkinje cells.
INPP5A specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.
INPP5A is a phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.
INPP5A has a specific catalytic domain that is responsible for its phosphatase activity. The structural details of INPP5A are important for understanding its function in inositol phosphate metabolism.
INPP5A functions as a hydrolase.
INPP5A regulates cellular signaling by controlling the levels of inositol phosphates, which are important secondary messengers in many cellular pathways.
Customer Reviews (3)
Write a reviewThe product's rapid action in triggering cellular responses significantly expedited our experiments.
The user-friendly design of the product made it accessible to researchers with varying levels of expertise.
The availability of technical experts for consultations greatly aided in optimizing our experiments.
Ask a Question for All INPP5A Products
Required fields are marked with *
My Review for All INPP5A Products
Required fields are marked with *
