INPP5D
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Official Full Name
inositol polyphosphate-5-phosphatase, 145kDa
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Overview
SHIP-1 p145 (SH2-containing-inositol phosphatase), an effector molecule, associates with activated Fms oncogenes. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1, 3, 4, 5 -tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways. -
Synonyms
INPP5D; inositol polyphosphate-5-phosphatase, 145kDa; inositol polyphosphate 5 phosphatase, 145kD; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; hp51CN; SHIP; SHIP-1; p150Ship; SH2 domain-containing inositol phosphatase 1; SH2 containing inositol phosphatase, isoform b; SH2 domain-containing inositol 5-phosphatase 1; SH2 domain-containing inositol-5-phosphatase 1; inositol polyphosphate-5-phosphatase of 145 kDa; signaling inositol polyphosphate 5 phosphatase SIP-145; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SHIP1; SIP-145; MGC104855; MGC142140; MGC142142;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- INPP5D Related Research Area
INPP5D involved in several pathways and played different roles in them. We selected most pathways INPP5D participated on our site, such as Inositol phosphate metabolism, Phosphatidylinositol signaling system, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | INPP4AB;ITPK1;MINPP1B;SYNJ2;PIP4K2AA;PIP5K1C;INPP5B;SYNJ1;PLCD3 |
| Phosphatidylinositol signaling system | INPPL1;DGKD;MTMR1;CALM1;INPP4AB;ITPR1;PI4K2A;PI4KB;MTMR7 |
| B cell receptor signaling pathway | PPP3CA;PIK3CA;HRAS;SYK;AKT1;CD79A;PILRB;MAP2K1;MAPK3 |
| Fc epsilon RI signaling pathway | IL5;MAP2K1;NRAS;PIK3CD;LCP2;AKT1;IL4;RAC3;RAC1 |
| Fc gamma R-mediated phagocytosis | BIN1;INPP5D;MAPK1;PIK3R5;PIP5K1A;DOCK2;PRKCB;FCGR2A;VAV1 |
INPP5D has several biochemical functions, for example, PTB domain binding, SH3 domain binding, inositol-polyphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5D itself. We selected most functions INPP5D had, and list some proteins which have the same functions with INPP5D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PTB domain binding | NUP62;INPP5D;INSR;APP |
| SH3 domain binding | EVLB;ABL1;CRB3;CBL;SOS1;EPS15;KHDRBS3;QKI2;PTPN12 |
| inositol-polyphosphate 5-phosphatase activity | INPP5E;INPP5J;INPP5K;INPP5A;INPPL1;INPP5D |
| phosphatidylinositol trisphosphate phosphatase activity | INPP5D;INPP5K;INPP4B |
| protein binding | PTGDS;LHFPL5;BLOC1S2;LTBP2;PPP6R2;ITGB4;DNASE1;TMEM171;CASP7 |
INPP5D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5D here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5D.
KHDRBS3; FCGR2B; KRTAP10-7; KRTAP10-9; KRT31; KRT40
- Q&As
- Reviews
Q&As (7)
Ask a questionINPP5D has specific domains that are responsible for its phosphatase activity, and understanding its structural details is important for comprehending its function in inositol phosphate metabolism.
INPP5D is an enzyme involved in the dephosphorylation of inositol phosphates, specifically in the conversion of inositol 1,3,4,5-tetrakisphosphate (IP4) to inositol 1,3,4-trisphosphate (IP3).
INPP5D is a subject of research, particularly in the context of cancer therapy and immunotherapy, as its modulation may affect immune cell function and cancer progression.
INPP5D is involved in regulating processes like cell growth, immune responses, and cytoskeletal dynamics by modulating inositol phosphate signaling.
The activity of INPP5D can be regulated through post-translational modifications and interactions with other proteins.
Dysregulation of INPP5D can impact various cellular functions and has been associated with immune-related disorders and cancer.
INPP5D is primarily located in the cytoplasm and plays a role in regulating inositol phosphate levels within the cell.
Customer Reviews (3)
Write a reviewThe responsive customer support team provided quick resolutions to any queries or issues we encountered.
We valued the product's safety profile, which ensured the well-being of our researchers and the integrity of our experiments.
Consistency in its performance over time made it a reliable resource for ongoing experiments.
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