INPP5E
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Official Full Name
inositol polyphosphate-5-phosphatase, 72 kDa
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Overview
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. -
Synonyms
INPP5E; inositol polyphosphate-5-phosphatase, 72 kDa; JBTS1, Joubert syndrome 1; 72 kDa inositol polyphosphate 5-phosphatase; CORS1; PPI5PIV; Inositol polyphosphate 5 phosphatase; Phosphatidylinositol (4,5) bisphosphate 5 phosphatase; Phosphatidylinositol polyphosphate 5 phosphatase type IV; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; phosphatidylinositol (4,5) bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV; CPD4; JBTS1; MORMS;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E. coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- INPP5E Related Articles
INPP5E involved in several pathways and played different roles in them. We selected most pathways INPP5E participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | MTMR6;ITPK1A;IMPA2;IPPK;PLCZ1;MTMR1B;ITPKB;INPP5L;MTMR1 |
| Metabolic pathways | CYP4A10;GULO;AGXTA;TBXAS1;GNPDA1;PDHA2;GCNT4;UGT2A2;POLD2 |
| Phosphatidylinositol signaling system | ITPR3;PIK3R3B;CALM1B;PLCD4;PIK3C2A;INPP4AB;PIP5K1C;PRKCB;MTMR4 |
INPP5E has several biochemical functions, for example, inositol-polyphosphate 5-phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5E itself. We selected most functions INPP5E had, and list some proteins which have the same functions with INPP5E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol-polyphosphate 5-phosphatase activity | INPP5J;INPP5A;INPP5D;INPPL1;INPP5E;INPP5K |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | SYNJ2;PTPMT1;EPM2A;INPP5E;INPP5B;OCRL |
INPP5E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5E here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5E.
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, partly through an AKT-dependent mechanism, the interaction between INPP5E and AURKA affects the downregulation of AURKA.
INPP5E plays a significant role in ciliary biology and is associated with ciliopathies like Joubert and MORM syndromes.
INPP5E's increased 5-phosphatase activity promotes transcriptional downregulation of AURKA.
INPP5E interacts with AURKA, a centrosomal kinase that regulates mitosis and ciliary disassembly.
This interaction establishes the first direct link between AURKA and phosphoinositide signaling.
The interaction between INPP5E and AURKA is crucial for maintaining the stability of primary cilia.
AURKA phosphorylates INPP5E, enhancing its 5-phosphatase activity.
Customer Reviews (3)
Write a reviewWe felt well-supported throughout our usage of the product, thanks to the dedicated customer service.
Its ease of use allowed us to focus more on data analysis and interpretation, rather than technical challenges.
The product's ability to accelerate research progress made it invaluable for time-critical projects.
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