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INPPL1

  • Official Full Name

    inositol polyphosphate phosphatase-like 1

  • Overview

    SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and tw
  • Synonyms

    INPPL1; inositol polyphosphate phosphatase-like 1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; 51C protein; SHIP2; SHIP-2; INPPL-1; protein 51C; SH2 domain-containing inositol 5-phosphatase 2; SH2 domain-containing inositol-5-phosphatase 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INPPL1-5101H Recombinant Human INPPL1 Protein, GST-tagged Wheat Germ GST
Human INPPL1-2891H Recombinant Human INPPL1 protein, His-tagged E.coli His 74-366 aa
Mouse INPPL1-8232M Recombinant Mouse INPPL1 Protein Mammalian Cell His
Mouse INPPL1-4559M Recombinant Mouse INPPL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse INPPL1-4559M-B Recombinant Mouse INPPL1 Protein Pre-coupled Magnetic Beads HEK293
Rat INPPL1-3075R Recombinant Rat INPPL1 Protein Mammalian Cell His
Rat INPPL1-2731R-B Recombinant Rat INPPL1 Protein Pre-coupled Magnetic Beads HEK293
Rat INPPL1-2731R Recombinant Rat INPPL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque INPPL1-2278R Recombinant Rhesus monkey INPPL1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque INPPL1-2099R-B Recombinant Rhesus Macaque INPPL1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque INPPL1-2099R Recombinant Rhesus Macaque INPPL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • INPPL1 Related Articles
  • INPPL1 Related Research Area

INPPL1 involved in several pathways and played different roles in them. We selected most pathways INPPL1 participated on our site, such as Inositol phosphate metabolism, Phosphatidylinositol signaling system, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inositol phosphate metabolismIMPA1;INPP5B;INPP4AB;MTMR2;PIK3CD;NUDT4B;PI4K2B;PLCE1;INPP5J
Phosphatidylinositol signaling systemPIK3R3B;DGKE;INPP5KA;CALML5;OCRL;PIK3R1;MTM1;SYNJ2;MTMR8
B cell receptor signaling pathwaySYK;TTC6;CD19;CD79A;GRB2;MAP2K2;ARPC1B;CDK4;PIK3AP1
Fc gamma R-mediated phagocytosisPPAP2A;FCGR1A;PLCG2;PLA2G6;PLCG1;MARCKS;CDC42;cgr2b;PIP5K1B
Insulin signaling pathwayPRKAG3B;PTPRFB;MAPK3;RAF1;FLOT2A;INS2;PPP1CAA;PRKAB1A;G6PC3

INPPL1 has several biochemical functions, for example, SH2 domain binding, SH3 domain binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INPPL1 itself. We selected most functions INPPL1 had, and list some proteins which have the same functions with INPPL1. You can find most of the proteins on our site.

Function Related Protein
SH2 domain bindingSHCBP1;LCK;INPPL1;SYP;SH3PXD2B;IRS1;KHDRBS2;SKAP1;GNB2L1
SH3 domain bindingENKUR;EFS;INPP5D;WIPF3;USP8;PLSCR4;NCF1;FMN1;ITGB1BP2
actin bindingMYHZ1.2;TWF2B;TPM4;SVILA;PIP;GCET2;PLEKHH2;CXCR4;GMFB
hydrolase activityCTSSA;CAPN5A;BPGM;PGAM1;Adamts19;MMP13A;C6AST1;ACTG2;NUDT22
inositol-polyphosphate 5-phosphatase activityINPPL1;INPP5A;INPP5E;INPP5K;INPP5D;INPP5J
phosphatidylinositol-3,4,5-trisphosphate bindingDAPP1;ARAP1;GBF1;MYO1G;FERMT2;ANXA8;RS1;NRGN;GAB2
protein bindingDRD2;TAF7L;ARAF;FAM46B;ZSCAN16;HTR3E;PSMB10;TCP1;ATP2B1

INPPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INPPL1.

PTPN1; Sorbs3; Itsn1; Shc1; LRRK1

Iida, A; Okamoto, N; et al. Exome sequencing identifies a novel INPPL1 mutation in opsismodysplasia. JOURNAL OF HUMAN GENETICS 58:391-394(2013).
Below, JE; Earl, DL; et al. Whole-Genome Analysis Reveals that Mutations in Inositol Polyphosphate Phosphatase-like 1 Cause Opsismodysplasia. AMERICAN JOURNAL OF HUMAN GENETICS 92:137-143(2013).
  • Q&As
  • Reviews

Q&As (7)

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Which gene encodes the INPPL1 protein? 10/20/2022

The INPPL1 protein is encoded by the INPPL1 gene.

What is the primary role of INPPL1 in cells? 12/11/2021

INPPL1 plays a key role in regulating insulin signaling and glucose metabolism.

Is INPPL1 involved in lipid metabolism? 05/20/2021

Yes, INPPL1 is known to be involved in lipid metabolism and can affect insulin sensitivity.

Are there any known diseases associated with mutations in the INPPL1 gene? 09/11/2018

Mutations in INPPL1 have been linked to insulin resistance and type 2 diabetes.

What is the molecular weight of INPPL1? 11/26/2017

The molecular weight of INPPL1 is approximately 135 kDa.

What is the full name of the INPPL1 protein? 08/08/2017

INPPL1 is often referred to as "Inositol Polyphosphate Phosphatase-Like 1."

Where is INPPL1 primarily localized within cells? 11/11/2016

INPPL1 is mainly found in the cytoplasm and can translocate to the plasma membrane.

Customer Reviews (3)

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Reviews
07/18/2022

    Remarkable changes in cell behavior were attributed to the potent effects of the product.

    02/25/2019

      Despite its cost, the product's contributions to our research goals made it an invaluable asset.

      09/30/2017

        Our research benefited greatly from the product's ability to induce specific cellular responses, enriching our findings.

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