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INTS3

Official Full Name

integrator complex subunit 3
Overview

INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large;subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2;(RNU2; MIM 180690) (Baillat et al., 2005 (PubMed 16239144)). INTS3 is also a subunit of single-stranded DNA;(ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) (PubMed;19683501).
Synonyms

INTS3; integrator complex subunit 3; C1orf60, chromosome 1 open reading frame 60; FLJ21919; INT3; C1orf193; C1orf60; INT 3; SOSS complex subunit A; RP11-216N14.4; sensor of ssDNA A; OTTHUMP00000035161; OTTHUMP00000038687; OTTHUMP00000222672; sensor of ssDNA subunit A; sensor of single-strand DNA complex subunit A; SOSS-A; RP11-216N14.2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

C
His
GST
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	INTS3-130H	Recombinant Human INTS3, His-tagged	E.coli	His	91-445aa	$319 / 25ug
Human	INTS3-3618H	Recombinant Human INTS3 Protein (Thr641-Leu895), C-His tagged	E.coli	C-His	Thr641-Leu895	Inquiry
Human	INTS3-5088H	Recombinant Human INTS3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	INTS3-5672HF	Recombinant Full Length Human INTS3 Protein, GST-tagged	In Vitro Cell Free System	GST	1042 amino acids	Inquiry
Mouse	INTS3-8247M	Recombinant Mouse INTS3 Protein	Mammalian Cell	His		Inquiry
Mouse	INTS3-4567M	Recombinant Mouse INTS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Ints3-5761M	Recombinant Mouse Ints3 Protein (Thr639-Lys891), C-His tagged	E.coli	C-His	Thr639-Lys891	Inquiry
Mouse	INTS3-4567M-B	Recombinant Mouse INTS3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	INTS3-4033Z	Recombinant Zebrafish INTS3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
INTS3 Related Articles

INTS3 involved in several pathways and played different roles in them. We selected most pathways INTS3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with INTS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

INTS3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INTS3 itself. We selected most functions INTS3 had, and list some proteins which have the same functions with INTS3. You can find most of the proteins on our site.

Function	Related Protein
protein binding	S100A6;BLOC1S2;CHMP4C;CRY2;MXD3;UBE3A;LCORL;ITPKB;TUBA1B

INTS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INTS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of INTS3.

ZBTB14; UBA1; UBE2N; UBE2V1; NFKB1; ssdna_dadc; E2F3; p27958-pro_0000037566; SNW1; CDC5L

Skaar, JR; Ferris, AL; et al. The Integrator complex controls the termination of transcription at diverse classes of gene targets. CELL RESEARCH 25:288-305(2015).

Stadelmayer, B; Micas, G; et al. Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes. NATURE COMMUNICATIONS 5:-(2014).