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IPO9

Official Full Name

importin 9
Overview

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.
Synonyms

IPO9; importin 9; importin-9; FLJ10402; Imp9; ranBP9; ran-binding protein 9; DKFZp761M1547;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IPO9-1690H	Recombinant Human IPO9 Protein, His&GST-tagged	E.coli	N-His&GST	Val39-Glu213	Inquiry
Zebrafish	IPO9-12694Z	Recombinant Zebrafish IPO9	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

IPO9 involved in several pathways and played different roles in them. We selected most pathways IPO9 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IPO9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

IPO9 has several biochemical functions, for example, Ran GTPase binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO9 itself. We selected most functions IPO9 had, and list some proteins which have the same functions with IPO9. You can find most of the proteins on our site.

Function	Related Protein
Ran GTPase binding	RANGAP1;IPO8;IPO13;RANBP1;RANBP2;IPO5;TNPO1;NUTF2;BIRC5
protein transporter activity	AP2S1;XPO6;CALCR;AP4S1;SNUPN;VPS26B;COG3;IPO9;KPNA2

IPO9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO9 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO9.