IRAK4
-
Official Full Name
interleukin-1 receptor-associated kinase 4
-
Overview
IRAK-4 is a member of the interleukin-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon phosphorylation, IRAK-4 interacts with IRAK-1, MYD88 and TRAF6 to form a complex, and activate NF-kB and MAPK pathways (2-3). IRAK-4 phosphorylates and activates IRAK-1 at thr387 and is also known to interact with IRAK-1 but not with the other IRAK members. Additionally, like IRAK-1, IRAK-4 possesses an auto and crossphosphorylation kinase activity (4). -
Synonyms
IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- Baculovirus-Insect cells
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- Myc
- DDK
- Flag
- GST
- His (Fc)
- Avi
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- IRAK4 Related Articles
- IRAK4 Related Research Area
IRAK4 involved in several pathways and played different roles in them. We selected most pathways IRAK4 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
NF-kappa B signaling pathway | RELA;UBE2I;TNFAIP3;LAT;MAP3K14;CXCL12;RELB;TRIM25;TNFSF14 |
Apoptosis | TNFRSF10D;ENDOG;HRK;HIST1H1A;PIK3R3A;BAXA;PIK3R2;IRF2;RNF8 |
Toll-like receptor signaling pathway | Ifna15;IKBKG;TLR2-1;MAP2K2A;MAP2K7;PIK3R1;CD86;MAPK12A;AKT3A |
Neurotrophin signaling pathway | ABL1;CAMK2A;CALM1;RAC1;CALML5;MATK;NRAS;MAP2K7;KIDINS220 |
Pertussis | ITGAM;IL1A;PYCARD;ITGB2L;C4BPA;CASP1;TICAM2;NFKB1;CD14 |
Leishmaniasis | TNF;FCGR3B;IRAK1;ITGAM;HLA-DRB3;PTPN6;FOS;NCF2;FCGR1A |
Chagas disease (American trypanosomiasis) | CD3E;FASLG;GNAI1;TLR6;IL1B;SMAD2;GNAL;C1QC;TGFBR2 |
Toxoplasmosis | LDLR;MAPK1;HLA-DMB;BIRC2;Toxoplasma Gondii Profilin Family Protein;HLA-DOB;GNAO1;IFNG;XIAP |
Tuberculosis | FCGR3;TGFB3;IFNB1;TRAF6;IL23;MYD88;HSPA9;BAD;AKT1 |
Measles | EIF2AK1;RCHY1;TRP53;IFNAR1;HSPA1B;MSN;IFNA12;IFNGR1;FCGR2B |
Influenza A | FURIN;MAP2K1;PIK3CG;Ifna15;HLA-DRB1;MAPK8;HLA-DRA;MAPK1;IRF7 |
IRAK4 has several biochemical functions, for example, ATP binding, interleukin-1 receptor binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK4 itself. We selected most functions IRAK4 had, and list some proteins which have the same functions with IRAK4. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | MARK2;DYRK1B;MYO6B;DDX24;MAP3K13;NLRP4B;XRCC5;TRMU;BMX |
interleukin-1 receptor binding | IL1F10;TLR5;TLR9;IRAK1;IL1B;TRIP6;IL1A;IL37;IL36B |
magnesium ion binding | NIM1;ERN2;IRAK4;BPNT1;NT5C1B;PKM2;TREX2;ITPK1;NLK |
protein binding | CRCT1;EWSR1A;CNTNAP4;IQUB;CDCA4;MMP15;JAK3;SRPK3;NUP205 |
protein kinase activity | SGK196;SNRKA;MAP4K6;LMTK3;MAP4K1;PRKCBA;CAMKV;SCYL1;KITB |
protein serine/threonine kinase activity | PRKCE;HIPK3;CAMK1DB;TGFBR1B;STRC;TGFBR1A;PRKD2;RPS6KA3B;CDK14 |
IRAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK4.
PELI2; IRAK1; TIRAP; PELI1; TNFRSF13B; IL1RL1; Irak3; ARNT; TBPL1; MYD88; IRAK2; KIF11
- Q&As
- Reviews
Q&As (5)
Ask a questionRheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.
Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.
Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.
Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.
By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.
Customer Reviews (3)
Write a reviewIts potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.
Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.
They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.
Ask a Question for All IRAK4 Products
Required fields are marked with *
My Review for All IRAK4 Products
Required fields are marked with *