IRF3
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Official Full Name
interferon regulatory factor 3
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Overview
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] -
Synonyms
IRF3; interferon regulatory factor 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|Myc
- His|SUMO
- His|T7
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- IRF3 Related Articles
- IRF3 Related Gene Family
- IRF3 Related Research Area
IRF3 involved in several pathways and played different roles in them. We selected most pathways IRF3 participated on our site, such as Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Toll-like receptor signaling pathway | AKT2;LY96;CD86;TBK1;MAP3K7;PIK3CG;MAPK8A;CCL4L2;TLR5 |
RIG-I-like receptor signaling pathway | MAP3K1;CXCL10;MAPK9;IL12B;IFNA16;OTUD5A;IFNA13;IL8L2;TNF |
Cytosolic DNA-sensing pathway | IKBKB;NFKB1;IL1B;POLR2EB;IFNPHI3;IFNA10;NFKBIB;POLR3D;IL6 |
Pertussis | C4BPB;IRF1;GNAI1;MAPK12;RHOA;SERPING1;CFL2;IRAK4;C4BP |
Hepatitis C | PIAS1;PIK3R1;CLDN5;ARAF;OAS1A;GRB2;IFNA21;SOCS3;Ifna15 |
Hepatitis B | MAPK8;DDB2;CXCL8;CCNE1;STAT3;PRKCB;IFNA1;CCNA1;NFATC3 |
Measles | HSPA1B;Ifna11;TBK1;CD3E;TLR7;TLR4;PIK3CB;Il2;TP53 |
Influenza A | IFNAR2;TMPRSS2;IFIH1;PRKCA;PIK3R2;PRKCB;HLA-DRB3;TNFRSF10B;HLA-DRB5 |
Herpes simplex infection | CUL1A;SKP1;OAS3;EIF2AK3;CDC34A;IFNA17;EIF2AK2;TRAF3;HLA-DQB1 |
Epstein-Barr virus infection | PIK3R1;CD19;POLR2C;EIF2AK1;YWHAZ;PSMD4;BCL2;AKT2;TRAF6 |
Viral carcinogenesis | IL6ST;TBPL2;KRAS;TRP53;BAD;RHOA;YWHAE;HIST1H4N;PXN |
IRF3 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF3 itself. We selected most functions IRF3 had, and list some proteins which have the same functions with IRF3. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | TSN;ZNF684;RAG1;ZNF37A;CROP;TRNP1;TIGD5;DNMT3A;ZBTB26 |
identical protein binding | TGFB3;GLUD1;ROBO2;JMJD6;ALCAMA;PPP1R13L;SNX33;APOH;ORAI1 |
protein binding | CRIPT;TRAM1;NUP107;PTPN11A;RNF7;EIF4A1;SRMS;DDB1;TRIM69 |
protein homodimerization activity | IRAK3;KCNE2;KCNH2;BAK1;ANXA6;ACTN3;PLEKHB1;ENO2;HELT |
regulatory region DNA binding | IRF8;IRF3;IRF4A;HMGA2;IRF1B;NFKB1;IRF1A;IRF5;IRF6 |
transcription cofactor activity | MXD1;LDB1B;MED1;NFE2L1;MED16;ELK4;LDB2B;TRIP13;TFB2M |
transcription factor activity, sequence-specific DNA binding | RARGB;HES1;HLFA;ZNF287;TBX22;ZNF544;SP3A;CEBPA;TFDP1A |
IRF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF3.
TBK1; CREBBP
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