Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

IRS4

  • Official Full Name

    Insulin receptor substrate 4

  • Overview

    IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.
  • Synonyms

    IRS4; nsulin receptor substrate 4; pp160; phosphoprotein of 160 kDa; 160 kDa phosphotyrosine protein; IRS-4; PY160;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRS4-1052H Recombinant Human IRS4 protein, His & T7-tagged E.coli His/T7 Met1~Arg196 (Accession # O14654)
Human IRS4-5157HCL Recombinant Human IRS4 293 Cell Lysate HEK293 N/A
Human IRS4-5028H Recombinant Human IRS4 Protein, GST-tagged Wheat Germ GST
Mouse IRS4-8316M Recombinant Mouse IRS4 Protein Mammalian Cell His
Mouse Irs4-1053M Recombinant Mouse Irs4 protein, His & T7-tagged E.coli His/T7 Met1~Arg299 (Accession # Q9Z0Y7)
Mouse IRS4-4612M-B Recombinant Mouse IRS4 Protein Pre-coupled Magnetic Beads HEK293
Mouse IRS4-4612M Recombinant Mouse IRS4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

IRS4 involved in several pathways and played different roles in them. We selected most pathways IRS4 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayATP2B4;NFATC1;MAP2K1;LOC100328615;CALM4;CREB3L1;ATP1A3;PIK3CD;IRS2
FoxO signaling pathwaySLC2A4;ATG12;INS1;MAPK3;NLK;PDPK1B;TGFB1;CDKN2D;HOMER3
AMPK signaling pathwayRPS6KB2;PPP2R5E;FBP2;PRKAG3;PRKAB2;SLC2A4;ADIPOR2;IGF1;CREB3
Insulin signaling pathwayRAPGEF1B;PRKAG3B;SHC4;MKNK2A;G6PCA.1;PPP1R3DA;PCK1;HK1;TSC1B
Adipocytokine signaling pathwayADIPOQ;ACSL3;TRADD;PRKAG3B;STAT3;IKBKB;NPY;MAPK9;CAMKK1
Regulation of lipolysis in adipocytesPRKACA;PTGER3;PIK3CG;INS2;PIK3CB;INS;INS1;IRS4;GNAI3
Type II diabetes mellitusPKLR;MTOR;TNF;CACNA1G;HK3;PIK3R5;SOCS1;SOCS2;INSR

IRS4 has several biochemical functions, for example, SH3/SH2 adaptor activity, insulin receptor binding, phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS4 itself. We selected most functions IRS4 had, and list some proteins which have the same functions with IRS4. You can find most of the proteins on our site.

Function Related Protein
SH3/SH2 adaptor activityGRAP;SLA2;PTPN11;LAT;SOCS2;ARHGAP4;FCRL2;CD28;SHB
insulin receptor bindingDOK1;PTPN1;SLC2A2;FRS3;INS1;DOK2;DOK7;INS;SNX1
phosphatidylinositol 3-kinase bindingCALM2;IGF1R;CALM1;IRS4;IGF1RA;DAB1;PDGFRB;BECN1;TYRO3
protein bindingATP10A;NFIX;NCBP1;C2orf29;ZBTB8A;C10orf81;IFT122;C1QL1;SOCS2
signal transducer activitySECTM1;GNGT1;LPAR6;CXXC5;OLFR469;PTK2BB;OLFR508;GPR124;GPR141

IRS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS4.

YWHAB; P; PTGES3; CRK; PPP2R2B; EGFR; ERBB2

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All IRS4 Products

Required fields are marked with *

My Review for All IRS4 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends