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ITGAX

Official Full Name

integrin, alpha X (complement component 3 receptor 4 subunit)
Overview

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit); CD11C; SLEB6;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E. coli
E.coli
HEK293
HEK293F
Human Cell
Insect Cell
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

C
His
Flag|His
GST
His (Fc)
Avi
His|GST
His|Myc
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ITGAX-1553H	Recombinant Human ITGAX protein, His-tagged	E.coli	His	Gln143~Ser344	Inquiry
Human	ITGAX-266H	Recombinant Human ITGAX	Mammalian Cell	His		Inquiry
Human	ITGAX-4119H	Recombinant Human ITGAX, flag & His tagged	Human Cell	Flag/His		$623 / 50 µg
Human	ITGAX & ITGB2-1875HCL	Recombinant Human ITGAX & ITGB2 cell lysate	Human Cell	N/A		Inquiry
Human	ITGAX-4324H	Recombinant Human ITGAX Protein (Met1-Pro1107), C-His tagged	Mammalian cells	C-His	Met1-Pro1107	Inquiry
Human	ITGAX-4987H	Recombinant Human ITGAX Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ITGAX-183H	Recombinant Human ITGAX protein, His-tagged	E. coli	His	21-352 aa	Inquiry
Human	ITGAX-3177H-B	Recombinant Human ITGAX Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	ITGAX-1223H	Recombinant Human ITGAX Protein (Phe20-Pro1107), N-His tagged	E.coli	N-His	Phe20-Pro1107	Inquiry
Human	ITGAX-1066H	Recombinant Human ITGAX Protein, His-tagged	HEK293F	N-His	Gln143-Ser344	Inquiry
Human	ITGAX-3177H	Recombinant Human ITGAX Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Itgax-1554M	Recombinant Mouse Itgax protein, His & GST-tagged	E.coli	His/GST	Arg907~Val1115 (Accession # Q9QXH4)	Inquiry
Mouse	ITGAX-2812M	Recombinant Mouse ITGAX Protein (20-1116 aa), His-MBP-tagged	Insect Cell	His/Myc	20-1116 aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein
ITGAX Related Articles
ITGAX Related Research Area

ITGAX involved in several pathways and played different roles in them. We selected most pathways ITGAX participated on our site, such as Regulation of actin cytoskeleton, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Regulation of actin cytoskeleton	ARHGEF7A;FGF2;MLCK2;PFN4;FGD;GSNA;BAIAP2A;PPP1R12B;MAP2K2
Tuberculosis	Pla2r1;TLR2;LAMP2;RIPK2;ITGAM;NFYC;HLA-DMA;PPP3R1;IFNA1

ITGAX has several biochemical functions, for example, metal ion binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAX itself. We selected most functions ITGAX had, and list some proteins which have the same functions with ITGAX. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	ZNF486;ZNF697;FAM164A;AGMAT;BMP1A;TRIM41;PCXB;GALNT4;ACVR2AA
protein binding	TDP2;JUNB;SID4;SYT17;STX7;FGFR1B;RPP25L;KIAA0247;HSPA1A
receptor activity	ANTXRL;ANXA2R;CD33;CD2;MED4;MED16;NLGN1;GRIA3B;VMN1R41

ITGAX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAX here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAX.

ITGB2; pepT

Immig, K; Gericke, M; et al. CD11c-Positive Cells from Brain, Spleen, Lung, and Liver Exhibit Site-Specific Immune Phenotypes and Plastically Adapt to New Environments. GLIA 63:611-625(2015).

Williams, KA; Lee, M; et al. A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes. PLOS GENETICS 10:-(2014).

MDSC Phenotyping - Negative Markers

Integrins

Conventional/Classical Dendritic Cells

Inflammatory/Monocyte-derived Dendritic Cells

Langerhans and Dermal Dendritic Cells

Plasmacytoid Dendritic Cells

Basophils

Granulocyte Markers

Macrophage Markers

Monocyte Markers

Natural Killer Cells (NK Cells) Markers

B Cell Chemotaxis, Migration, and Adhesion