ITGB2
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Official Full Name
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
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Overview
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. -
Synonyms
95 subunit beta; Beta 2 (antigen CD18 (p95); CD 18; CD18; CD18 antigen; Cell surface adhesion glycoprotein LFA 1/CR3/P150, 959 beta subunit precursor); Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p150, 95 subunit beta; Cell surface adhesion glycoproteins LFA 1/CR3/p15095 beta subunit; Cell surface adhesion glycoproteins LFA-1/CR3/p150; Complement component 3 receptor 3 and 4 subunit; Complement receptor C3 beta subunit; Complement receptor C3 subunit beta; Integrin beta 2; Integrin beta chain beta 2; Integrin beta-2; Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITB2_HUMAN; ITGB 2; ITGB2; LAD; LCAMB; Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C; Leukocyte Cell Adhesion Molecule CD18; LFA 1; LFA1; Lymphocyte function associated antigen 1; MAC 1; MAC1; Macrophage antigen 1 (mac1) beta subunit; MF17; MFI7; LFA-1; MAC-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Antibody
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Sus scrofa (Pig)
- CHO
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Rat
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|Avi
- His|T7
- Myc
- DDK
- N/A
- N
- T7|His
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ITGAM&ITGB2-692H | Active Recombinant Human ITGAM&ITGB2 | CHO | N/A |
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| Human | ITGB2-181H | Recombinant Human ITGB2 protein, T7/His-tagged | E.coli | T7/His |
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| Human | ITGB2-26325TH | Recombinant Human ITGB2 | Wheat Germ | N/A | 100 amino acids |
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| Human | ITGB2-26324TH | Recombinant Human ITGB2 | Wheat Germ | N/A | 769 amino acids |
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| Human | ITGB2-71H | Recombinant Human ITGB2 protein, His-tagged | Insect Cell | His |
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| Human | ITGAX & ITGB2-1875HCL | Recombinant Human ITGAX & ITGB2 cell lysate | Human Cell | N/A |
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| Human | ITGB2-5125HCL | Recombinant Human ITGB2 293 Cell Lysate | HEK293 | N/A |
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| Human | ITGB2-4978H | Recombinant Human ITGB2 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ITGB2-279HF | Recombinant Full Length Human ITGB2 Protein | In Vitro Cell Free System | 769 amino acids |
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| Human | ITGB2-1067H | Recombinant Human ITGB2 Protein, His-tagged | E.coli | N-His | Gln23-Val367 |
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| Human | ITGB2-248HFL | Active Recombinant Full Length Human ITGB2 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | ITGAL & ITGB2-7130H | Recombinant Human ITGAL & ITGB2 Protein, His-Avi-tagged, Biotinylated | HEK293 | His/Avi | ||
| Human | ITGB2-280HF | Recombinant Full Length Human ITGB2 Protein | In Vitro Cell Free System | 100 amino acids |
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| Human | ITGB2-5780HF | Recombinant Full Length Human ITGB2 Protein, GST-tagged | In Vitro Cell Free System | GST | 769 amino acids |
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| Human | ITGB2-1052H | Recombinant Human ITGB2 Protein (Gly124-Leu363), N-GST tagged | E.coli | N-GST | Gly124-Leu363 |
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| Human | ITGB2-1922H | Recombinant Human ITGB2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | ITGB2-1216H | Recombinant Human ITGB2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | ITGB2-1216H-B | Recombinant Human ITGB2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Human | ITGB2-2556H | Recombinant Human ITGB2 protein(451-520 aa), C-His-tagged | E. coli | C-His | 451-520 aa |
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| Human | ITGB2-4326H | Recombinant Human ITGB2 Protein (Met1-Asn700), C-His tagged | Mammalian cells | C-His | Met1-Asn700 |
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| Mouse | Itgam&Itgb2-605M | Active Recombinant Mouse Itgam&Itgb2 | CHO | N/A |
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| Mouse | Itgb2-7145M | Recombinant Mouse Itgb2 protein, His & T7-tagged | E.coli | His/T7 | Ala431~Met652 (Accession # P11835) |
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| Mouse | DMABT-H24736 | Rat Anti-ITGB2 Monoclonal Antibody | Rat | N/A |
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| Mouse | Itgb2-3605M | Recombinant Mouse Itgb2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | Itgb2-7146R | Recombinant Rat Itgb2 protein, His & T7-tagged | E.coli | His/T7 | Val415~Gln678 (Accession # NM_001037780.2) |
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| Bos taurus (Bovine) | RFL798BF | Recombinant Full Length Bovine Integrin Beta-2(Itgb2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (23-769) |
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| Homo sapiens (Human) | RFL179HF | Recombinant Full Length Human Integrin Beta-2(Itgb2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (23-769) |
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| Mus musculus (Mouse) | RFL20219MF | Recombinant Full Length Mouse Integrin Beta-2(Itgb2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (24-771) |
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| Sus scrofa (Pig) | RFL9256SF | Recombinant Full Length Pig Integrin Beta-2(Itgb2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (23-769) |
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| Chicken | ITGB2-6803C | Recombinant Chicken ITGB2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ITGB2 Related Articles
ITGB2 involved in several pathways and played different roles in them. We selected most pathways ITGB2 participated on our site, such as Rap signaling pathway, Phagosome, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | FGF10;PIK3R1;SKAP1;LPAR5;PFN1;RAC3;FYB;Kitl;FGF9 |
| Phagosome | TUBA4A;HLA-A;FCAR;COLEC12;TLR4BB;BLB2;ITGB5;C3A.3;ATP6V0A4 |
| Hippo signaling pathway | ACTG1;WNT7A;STK3;FZD7;BTRC;GDF7;CCND3;CTNNA3;FZD8 |
| Cell adhesion molecules (CAMs) | HLA-DRB1;CD8A;BMA1;ITGA8;SELPLG;CLDN5A;HLA-DQA2;CLDN1;HLA-DRB3 |
| Natural killer cell mediated cytotoxicity | NCR2;NCR1;MICB;IFNA13;PIK3R2;IFNA12;TNFRSF10D;IFNA17;Raet1a |
| Leukocyte transendothelial migration | VAV2;ESAM;CXCL12;ICAM1;F11R;TXK;GNAI3;PIK3CG;EZR |
| Regulation of actin cytoskeleton | RAC1B;DIAP3;ITGB8;ROCK2A;GSNB;NRAS;ITGB2L;ACTN3;FGFR3 |
| Pertussis | C1QA;C1S;IRAK1;Il23a; Il12b;CD14;PYCARD;CFL2;CALML3;CALM4 |
| Legionellosis | NFKB2;HSPD1;BCL2L13;RAB1B;RAB1;APAF1;NFKB1;EEF1G;Itgam&Itgb2 |
| Leishmaniasis | FCGR3;HLA-DRB4;ITGB2;HLA-DMA;PTPN6;FCGR4;H2-AB1;HLA-DPA1;HLA-DPB1 |
| Malaria | ITGB2;HBA-A2;COMP;SELE;GYPA;LRP1;HBA2;HBB-B1;SDC1 |
| Amoebiasis | GM-CSF;NFKB1;CD14;PRKACA;ARG1;LAMB2;PIK3R3;LAMB3;COL4A6 |
| Staphylococcus aureus infection | C1QC;H2-AA;C3;FCGR4;SELP;FPR3;SELPLG;FCGR2C;HLA-DRB1 |
| Tuberculosis | ITGB2;TGFB2;Il23a; Il12b;IFNGR2;TRADD;PPP3CB;CALML5;HSPA9;ATP6V0B |
| HTLV-I infection | MSX1;SMAD4;HLA-DPA1;VDAC1;TGFBR2;BUB3;RAN;HLA-DRB1;WNT9B |
| Rheumatoid arthritis | ATP6V0E1;CCL3L3;TNFSF11;ATP6V1E1;H2-AB1;ATP6V1B1;ATP6V1G1;CCL3L1;TNFRSF11A |
| Viral myocarditis | HLA-DRB3;MYH7;ABL1;ITGB2;CCND1;HLA-DRB5;HLA-A;SGCA;HLA-DRB1 |
ITGB2 has several biochemical functions, for example, ICAM-3 receptor activity, cell adhesion molecule binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB2 itself. We selected most functions ITGB2 had, and list some proteins which have the same functions with ITGB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ICAM-3 receptor activity | ITGB2;CLEC4M;ITGAL |
| cell adhesion molecule binding | PTPRD;CADM4;CD1D;NCR3;CD200;FGG;SELL;CADM2;CADM3 |
| glycoprotein binding | PTBP3;FLNA;FBXO17;ITGB2;SERPINA1;Itgam&Itgb2;B2M;FBXO27;BMPR1B |
| metal ion binding | MBNL1;CYP2AA7;GMPR2;ZFP503;RNF121;ZFP36L3;PLAGL1;ASPA;NCS1A |
| protein binding | TUBB;PCSK5;HIST1H4L;SNAP47;OAS1A;STATH;NR5A1;RSAD2;ZNF79 |
| protein kinase binding | LAX1;HDAC4;IL12RB2;DCX;PRKAG1;NEK6;STAP1;CHEK2;CDC42 |
ITGB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB2.
RANBP9; TLN2; NOTCH2NL; RDX; COPS3; ABL1
Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
Madkaikar, M; Italia, K; et al. Molecular characterization of leukocyte adhesion deficiency-I in Indian patients: Identification of 9 novel mutations. BLOOD CELLS MOLECULES AND DISEASES 54:217-223(2015).
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