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ITGB8

  • Official Full Name

    integrin, beta 8

  • Overview

    This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
  • Synonyms

    ITGB8; integrin, beta 8; integrin beta-8; ITGB 8; OTTHUMP00000025212;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Oryctolagus cuniculus (Rabbit)
  • Rabbit
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGB8-183H Recombinant Human ITGB8, GST-tagged E.coli GST 76-439aa
Human ITGB8-881HCL Recombinant Human ITGB8 cell lysate N/A
Human ITGB8-4964H Recombinant Human ITGB8 Protein, GST-tagged Wheat Germ GST
Human ITGB8-255H Recombinant Human ITGB8 Protein, His-tagged E.coli His Cys471~Thr629
Rabbit ITGB8-2220R Recombinant Rabbit ITGB8 Protein, His-tagged Yeast His
Rabbit ITGB8-2297R Recombinant Rabbit ITGB8 Protein (146-384 aa), His-Myc-tagged E.coli His/Myc 146-384 aa
Homo sapiens (Human) RFL24947HF Recombinant Full Length Human Integrin Beta-8(Itgb8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (43-769)
Oryctolagus cuniculus (Rabbit) RFL30290OF Recombinant Full Length Rabbit Integrin Beta-8(Itgb8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (43-768)
Rhesus Macaque ITGB8-2317R Recombinant Rhesus monkey ITGB8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ITGB8-2138R Recombinant Rhesus Macaque ITGB8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ITGB8-2138R-B Recombinant Rhesus Macaque ITGB8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGB8 Related Research Area

ITGB8 involved in several pathways and played different roles in them. We selected most pathways ITGB8 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayITGA1;MAPK3;FGF21;SPP1;PPP2R5C;ITGA4;BCL2;CCND3;TSC2
Focal adhesionTHBS4;KDRL;MAPK4;PTEN;PDPK1B;ITGA9;GSK3AA;TNK1;LAMA4
ECM-receptor interactionLAMA5;GP5;LAMA3;SV2C;ITGB1B.2;COL2A1B;ITGA3;ITGB1;COL6A5
Cell adhesion molecules (CAMs)CD99;CLDN23;LRRC4B;ITGB1A;GLYCAM1;CLDN6;CLDN8;NLGN3A;MHC2DEB
Regulation of actin cytoskeletonFGFR3;ENAH;MYL10;PAK6;ITGA6B;PAK7;PDGFAB;CDC42L;MYLPFA
Hypertrophic cardiomyopathy (HCM)DAG1;RYR2;CACNG8;MYH7;MYBPC3;CACNG6;LAMA2;CACNG3;IL6
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ACTN4;CACNA2D4;PKP2;ITGA1;SGCG;ITGB6;CACNG7;CTNNA1;ITGA2B
Dilated cardiomyopathyCACNB4;CACNB3;ACTB;EMD;CACNG2;DAG1;Itga10&Itgb1;TNF;TGFB3

ITGB8 has several biochemical functions, for example, extracellular matrix protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB8 itself. We selected most functions ITGB8 had, and list some proteins which have the same functions with ITGB8. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix protein bindingITGAV;ITGB8;MEPE
receptor activityOR3A2;ABP1;CD86;NCR3;VMN1R52;CD46;CD2;IL10RA;CD40

ITGB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB8.

ITGAV

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