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ITK

  • Official Full Name

    IL2-inducible T-cell kinase

  • Overview

    This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
  • Synonyms

    ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell itk/tsk; interleukin-;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITK-1419H Active Recombinant Human ITK, GST-tagged Sf9 Insect Cell GST 352 aa-end
Human ITK-114H Active Recombinant Human ITK(352-617) Protein, N-His-tagged Sf21 His 352-617 aa
Human ITK-55H Recombinant Human ITK protein, Flag-tagged, Biotinylated Insect Cell Flag
Human ITK-335H Recombinant Human IL2-inducible T-cell Kinase, GST-tagged, Active Sf9 Insect Cell GST
Human ITK-5438H Recombinant Human IL2-Inducible T-Cell Kinase, GST-tagged Insect Cell GST
Human ITK-576H Recombinant Human ITK protein(Arg352-Leu620), GST-tagged Insect Cells N-GST Arg352-Leu620
Human ITK-29869TH Recombinant Human ITK N/A
Human ITK-2640H Recombinant Human ITK Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ITK-2227H Recombinant Human ITK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITK-1049H Recombinant Human ITK Protein (Arg352-Leu620), GST-tagged, Actived By LCK Insect Cell GST Arg352-Leu620
Human ITK-4961H Active Recombinant Human ITK Protein Insect Cell N/A
Human ITK-1311H Recombinant Human ITK Protein (M1-L620), Tag Free Insect Cell No tag M1-L620
Human ITK-3745H Recombinant Human ITK protein, His-tagged E.coli His 151-258 aa
Human ITK-1241HF Active Recombinant Full Length Human ITK Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 2-620(end)
Human ITK-4960H Recombinant Human ITK Protein, GST-tagged Wheat Germ GST
Human ITK-1223H-B Recombinant Human ITK Protein Pre-coupled Magnetic Beads HEK293
Human ITK-2292HF Active Recombinant Full Length Human ITK Protein, GST-tagged Insect (sf21) GST 2-620(end)
Human ITK-1301HFL Recombinant Full Length Human ITK Protein, C-Flag-tagged Mammalian cells Flag
Human ITK-109H Recombinant Human ITK protein, GST-tagged E. coli GST 151-258 aa
Human ITK-5813HF Recombinant Full Length Human ITK Protein, GST-tagged In Vitro Cell Free System GST 620 amino acids
Human ITK-1223H Recombinant Human ITK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITK-1312H Recombinant Human ITK Protein (M1-L620), GST tagged Insect Cell GST M1-L620
Human ITK36899H Recombinant Human ITK (357-620) Protein
Mouse Itk-861M Recombinant Mouse Itk Protein, GST & His-tagged Insect Cell GST/His Arg 351-Leu 619
Mouse ITK-418MCL Recombinant Mouse ITK cell lysate Insect Cell N/A
Mouse Itk-3615M Recombinant Mouse Itk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Itk-1564M Recombinant Mouse Itk protein, His & GST-tagged E.coli His/GST Leu368~Leu625 (Accession # Q03526)
Rhesus Macaque ITK-2318R Recombinant Rhesus monkey ITK Protein, His-tagged Mammalian Cell His
Rhesus Macaque ITK-2139R Recombinant Rhesus Macaque ITK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ITK-2139R-B Recombinant Rhesus Macaque ITK Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ITK-8728Z Recombinant Zebrafish ITK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITK Related Articles
  • ITK Related Research Area

ITK involved in several pathways and played different roles in them. We selected most pathways ITK participated on our site, such as Adaptive Immune System, B Cell Receptor Signaling Pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemAGO1;FBXO3;AP2S1;OSBPL1A;DYNC1I2;SPSB1;SPTBN2;MOV10;KIF2C
B Cell Receptor Signaling PathwayARPC5;CARD11;ACTR2;STAP1;NFKBIB;RAF1;VAV1;CRK;NFATC3
Chemokine signaling pathwayRAC1;ADRBK1;PIK3R2;PREX1;PRKCZ;CXCL5;GNGT1;VAV2;RASGRP2
Class I PI3K signaling eventsARF1;PLEKHA1;BLK;ADAP1;ITK
FCERI mediated Ca+2 mobilizationGRAP2B;IGLC2;IGKC;IGKV1-5;ITK;LCP2A;GRAP2A
Fc epsilon receptor (FCERI) signalingTAB1;LAT2;RASGRP2;GRAP2A;ITK;GRAP2B;LCP2A
Fc-epsilon receptor I signaling in mast cellsPTPN13;LAT2;S1PR1;DOK1;ITK
Generation of second messenger moleculesEVL;ITK;HLA-DQB2;GRAP2B;GRAP2A

ITK has several biochemical functions, for example, ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITK itself. We selected most functions ITK had, and list some proteins which have the same functions with ITK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCHD1L;RAD50;ABCA7;ACTB1;ATP13A5;ERBB3;EPHB2B;UBE2M;NEK8
metal ion bindingZNF134;RNF216;PFKP;INSM2;ZFP239;ZSCAN5A;ZFP36L3;CALM4;Reln
non-membrane spanning protein tyrosine kinase activityBAZ1B;PTK2AB;ABL1;WEE1;EIF2AK2;JAK2A;PTK6B;PTK2BB;WEE2
protein bindingUNKL;PCK2;MYPOP;CD300LH;DAPK2;NCBP1;FAM115A;CTDP1;MYH11
NOT receptor bindingTXK;BMX;BTK;LGI1;ITK;TEC;STYK1

ITK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITK here. Most of them are supplied by our site. Hope this information will be useful for your research of ITK.

LCP2; FASLG; ERBB2; MET; ERBB3; SPRR2A; GAB1; ABI1; IKBKG; HSP90AB1; WAS; G3BP1; EGFR; npm_alk

Sagiv-Barfi, I; Kohrt, HEK; et al. Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E966-E972(2015).
Bansal, Y; Silakari, O; et al. 2-Aminobenzimidazole conjugates of NSAIDS: novel compounds with immunomodulatory, anti-inflammatory and antioxidant actions. MEDICINAL CHEMISTRY RESEARCH 24:1170-1179(2015).
  • Q&As
  • Reviews

Q&As (5)

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What is the significance of ITK in allergic and autoimmune diseases, and how does it contribute to immune dysregulation in these conditions? 01/10/2022

ITK's involvement in Th2 cell differentiation links it to allergic diseases. Dysregulation of ITK is implicated in autoimmune diseases, influencing aberrant T-cell responses and immune system dysfunction.

Can you discuss the role of ITK in the context of immunodeficiency disorders, and how genetic variations impact its function? 12/01/2021

Deficiencies in ITK function are associated with immunodeficiency disorders. Genetic variations in ITK may compromise its kinase activity, leading to impaired T-cell signaling and immune responses.

What is the primary role of the ITK protein in T-cell signaling, and how does it contribute to immune responses? 10/17/2020

ITK is a tyrosine kinase involved in T-cell signaling, specifically in the activation of T-cell receptors. It plays a critical role in the regulation of immune responses and T-cell-mediated immunity.

Can you discuss the molecular mechanisms by which ITK is activated and its downstream signaling pathways in T cells? 02/27/2019

ITK is activated by phosphorylation and participates in downstream signaling pathways, including the PLCγ1 pathway, leading to the mobilization of calcium ions and activation of NFAT transcription factors.

How does ITK participate in the regulation of immune synapse formation, and what are the implications for T-cell activation and effector functions? 09/03/2018

ITK contributes to immune synapse formation by mediating cytoskeletal changes and promoting T-cell receptor clustering. This influences T-cell activation and the subsequent effector functions.

Customer Reviews (3)

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Reviews
06/28/2021

    Research-grade excellence. This product has simplified our experiments, and the quality is unmatched.

    06/15/2020

      The shipping speed surprised me! Got what I needed for our experiments right on schedule.

      10/06/2018

        Customer service that goes above and beyond. They truly understand our lab's needs

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