ITK
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Official Full Name
IL2-inducible T-cell kinase
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Overview
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. -
Synonyms
ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell itk/tsk; interleukin-;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Human
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- ITK Related Articles
- ITK Related Research Area
ITK involved in several pathways and played different roles in them. We selected most pathways ITK participated on our site, such as Adaptive Immune System, B Cell Receptor Signaling Pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | AGO1;FBXO3;AP2S1;OSBPL1A;DYNC1I2;SPSB1;SPTBN2;MOV10;KIF2C |
B Cell Receptor Signaling Pathway | ARPC5;CARD11;ACTR2;STAP1;NFKBIB;RAF1;VAV1;CRK;NFATC3 |
Chemokine signaling pathway | RAC1;ADRBK1;PIK3R2;PREX1;PRKCZ;CXCL5;GNGT1;VAV2;RASGRP2 |
Class I PI3K signaling events | ARF1;PLEKHA1;BLK;ADAP1;ITK |
FCERI mediated Ca+2 mobilization | GRAP2B;IGLC2;IGKC;IGKV1-5;ITK;LCP2A;GRAP2A |
Fc epsilon receptor (FCERI) signaling | TAB1;LAT2;RASGRP2;GRAP2A;ITK;GRAP2B;LCP2A |
Fc-epsilon receptor I signaling in mast cells | PTPN13;LAT2;S1PR1;DOK1;ITK |
Generation of second messenger molecules | EVL;ITK;HLA-DQB2;GRAP2B;GRAP2A |
ITK has several biochemical functions, for example, ATP binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITK itself. We selected most functions ITK had, and list some proteins which have the same functions with ITK. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CHD1L;RAD50;ABCA7;ACTB1;ATP13A5;ERBB3;EPHB2B;UBE2M;NEK8 |
metal ion binding | ZNF134;RNF216;PFKP;INSM2;ZFP239;ZSCAN5A;ZFP36L3;CALM4;Reln |
non-membrane spanning protein tyrosine kinase activity | BAZ1B;PTK2AB;ABL1;WEE1;EIF2AK2;JAK2A;PTK6B;PTK2BB;WEE2 |
protein binding | UNKL;PCK2;MYPOP;CD300LH;DAPK2;NCBP1;FAM115A;CTDP1;MYH11 |
NOT receptor binding | TXK;BMX;BTK;LGI1;ITK;TEC;STYK1 |
ITK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITK here. Most of them are supplied by our site. Hope this information will be useful for your research of ITK.
LCP2; FASLG; ERBB2; MET; ERBB3; SPRR2A; GAB1; ABI1; IKBKG; HSP90AB1; WAS; G3BP1; EGFR; npm_alk
- Q&As
- Reviews
Q&As (5)
Ask a questionITK's involvement in Th2 cell differentiation links it to allergic diseases. Dysregulation of ITK is implicated in autoimmune diseases, influencing aberrant T-cell responses and immune system dysfunction.
Deficiencies in ITK function are associated with immunodeficiency disorders. Genetic variations in ITK may compromise its kinase activity, leading to impaired T-cell signaling and immune responses.
ITK is a tyrosine kinase involved in T-cell signaling, specifically in the activation of T-cell receptors. It plays a critical role in the regulation of immune responses and T-cell-mediated immunity.
ITK is activated by phosphorylation and participates in downstream signaling pathways, including the PLCγ1 pathway, leading to the mobilization of calcium ions and activation of NFAT transcription factors.
ITK contributes to immune synapse formation by mediating cytoskeletal changes and promoting T-cell receptor clustering. This influences T-cell activation and the subsequent effector functions.
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