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ITPKB

  • Official Full Name

    inositol-trisphosphate 3-kinase B

  • Overview

    The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.
  • Synonyms

    ITPKB; inositol-trisphosphate 3-kinase B; inositol 1,4,5 trisphosphate 3 kinase B; IP3 3KB; IP3KB; 1D myo inositol trisphosphate 3 kinase B; Inositol 1 4 5 trisphosphate 3 kinase B; Inositol trisphosphate 3 kinase B; IP3 3 kinase; IP3 3 kinase B; IP3K; IP3K B; PIG 37; PIG37; Proliferation inducing protein 37; IP3 3-kinase B; insP 3-kinase B; OTTHUMP00000035705; proliferation-inducing protein 37; inositol 1,4,5-trisphosphate 3-kinase B; IP3K-B; IP3-3KB;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITPKB-883HCL Recombinant Human ITPKB cell lysate N/A
Human ITPKB-5840HF Recombinant Full Length Human ITPKB Protein, GST-tagged In Vitro Cell Free System GST 644 amino acids
Human ITPKB-4949H Recombinant Human ITPKB Protein, GST-tagged Wheat Germ GST
Human ITPKB-591H Recombinant Human ITPKB Protein (442-946 aa), His-SUMO-tagged E.coli His/SUMO 442-946 aa
Rat ITPKB-3124R Recombinant Rat ITPKB Protein Mammalian Cell His
Rat ITPKB-2780R Recombinant Rat ITPKB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ITPKB-2780R-B Recombinant Rat ITPKB Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ITPKB involved in several pathways and played different roles in them. We selected most pathways ITPKB participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), Calcium signaling pathway, D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)ITPKA;ITPK1;ITPKB
Calcium signaling pathwayPLCB1;VDAC2;PPIAA;ERBB3A;CHRNA7;RYR3;CACNA1SA;PPIF;ATP2B2
D-myo-inositol (1,3,4)-trisphosphate biosynthesisITPKA;ITPKB
Inositol phosphate metabolismPIK3C2G;SYNJ1;TPI1A;INPP1;MINPP1B;MINPP1A;MTMR7B;ITPKC;INPP5J
Metabolic pathwaysST8SIA5;P4HA1;IDUA;HK3;GCSHA;LIPF;CYP2C50;COMTA;FUT7
MetabolismSURF1;PDK3B;ISCUB;GLIPR1;DDAH1;COX16;CYP2A13;NOSTRIN;NUDT4
Phosphatidylinositol signaling systemCALML5;PIP5K1BB;CALM1A;PIK3R3B;MTMR3;PIP5K1C;PI4KAA;PTEN;PIP5K1AB
Synthesis of IP3 and IP4 in the cytosolITPKA;PLCD3;ITPKB

ITPKB has several biochemical functions, for example, ATP binding, calmodulin binding, inositol-1,4,5-trisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKB itself. We selected most functions ITPKB had, and list some proteins which have the same functions with ITPKB. You can find most of the proteins on our site.

Function Related Protein
ATP bindingKIF4;TRIOA;ACTBL2;DYNC1LI2;ACTR1;MTHFD1L;IARS2;ACOT12;CHD4A
calmodulin bindingCNN1A;MYO5C;SPHK1;MYO1E;MYO1D;MYO1C;MYO10;VAMP2;STRN
inositol-1,4,5-trisphosphate 3-kinase activityIP6K3;IPMKB;ITPKA;IP6K1;IPMK;ITPKB;ITPKC;IP6K2
protein bindingCLDN2;AMMECR1;THRB;TMEM67;TOR1B;RPLP1;PHC2;AURKAIP1;CLPTM1

ITPKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKB here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKB.

GOLGA2; PSME3; PDE4A; PDE4D; PDE4D; ADNP2; PIBF1; ESF1

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