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ITPR1

Official Full Name

Itpr1 inositol 1,4,5-trisphosphate receptor 1
Synonyms

ITPR1; inositol 1,4,5-trisphosphate receptor 1; inositol 1,4,5-trisphosphate receptor type 1; IP3R 1; insP3R1; IP3 receptor; opisthotonus; InsP3R type I; protein PCD-6; InsP> 3< R type I; type 1 InsP3 receptor; Purkinje cell protein 1; inositol 1,4,5-triphosphate receptor 1; type 1 inositol 1,4,5-trisphosphate receptor; inositol 1,4,5-trisphosphate-binding protein P400; opt; Ip3r; P400; Pcp1; IP3R1; Pcp-1; D6Pas2; InsP3R; Itpr-1; Gm10429; ENSMUSG00000072853;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ITPR1-4945H	Recombinant Human ITPR1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ITPR1-2346H	Recombinant Human ITPR1 Protein, His-tagged	E.coli	N-His	Gly112-Val287	Inquiry
Mouse	ITPR1-8389M	Recombinant Mouse ITPR1 Protein	Mammalian Cell	His		Inquiry
Mouse	ITPR1-4655M	Recombinant Mouse ITPR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ITPR1-4655M-B	Recombinant Mouse ITPR1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	ITPR1-4075C	Recombinant Chicken ITPR1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ITPR1 Related Articles

ITPR1 involved in several pathways and played different roles in them. We selected most pathways ITPR1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	PPP3CCB;CACNA1BA;ADCY1A;TNNC1B;CACNA1B;CHRM1;PRKCB;CYSLTR2;PHKA1
cGMP-PKG signaling pathway	PPP1CB;AKT2;PPP3CB;ATP1B3;ATP1A1;BNP;AGTR1A;SLC25A31;PDE2A
Phosphatidylinositol signaling system	PRKCBB;INPP5J;INPP4A;PIK3CG;PIK3C2B;PLCB1;CALML3;PIK3R1;PIK3R3
Oocyte meiosis	REC8;RBX1;YWHAE1;YWHAG1;CUL1;PPP2R5B;BUB1;CALM2A;RPS6KA1
Vascular smooth muscle contraction	PRKCBB;KCNMB4;PPP1CAA;PRKCH;ADCY1B;NPR1;PPP1R14AB;CALM1B;GUCY1A3
Gap junction	TUBA4A;GNA11B;PRKG1;TUBA1L2;GJA1;GRB2B;PRKACBB;CX43;PRKACG
Platelet activation	MYLK2;PLA2G4D;FGB;PLCB2;MYLK4;ARHGAP35;F2RL3;ARHGEF1;GNAI3
Circadian entrainment	PLCB4;GRIA3;GNAI1;GNG12;CALM1;GRIN2D;GNB4;ADCYAP1R1;RPS6KA5
Long-term potentiation	PLCB3;GRIN2D;ITPR3;PPP1CB;HRAS;GRIA1;RPS6KA3;ARAF;MAPK1
Retrograde endocannabinoid signaling	GRM5;GABRE;GABRA2;GRM1;GNG3;GNG4;GNG7;GNG2;GNAQ
Glutamatergic synapse	DLGAP1;GRIK1;SHANK1;HOMER3;Adcy4;PLCB3;PLCB2;GRM7;GNAI2
Cholinergic synapse	CHRM5;KCNQ2;KCNJ12;GNG11;AKT1;GNG3;GNAI1;CHRNA3;KCNJ6
Serotonergic synapse	APP;GNB2;PTGS1;PLCB1;PLA2G4F;ITPR3;SLC6A4;HTR6;ALOX5
Dopaminergic synapse	CAMK2G;PRKACB;PLCB1;GNAS;PPP2R2A;PPP2CA;ITPR1;MAPK11;CREB3L3
Long-term depression	NOS1;RAF1;GRIA2;PPP2R1A;MAP2K2;NRAS;PLA2G4F;PLCB2;PRKCG
Inflammatory mediator regulation of TRP channels	MAPK10;ASIC5;PLA2G4F;CYP2J2;CAMK2G;ASIC4;MAPK11;PIK3CG;HTR2A
GnRH signaling pathway	MAP2K6;ADCY2B;ATF4;GNA15.4;PLCB3;GRB2A;MAP2K2A;MAPK11;GNRH1
Estrogen signaling pathway	CREB3L3;PLCB3;GPR30;KRAS;SHC4;CREB5;FKBP5;PIK3R1;PIK3CB
Thyroid hormone synthesis	PAX8;DUOX2;HSP90B1;PLCB1;GPX3;IYD;GNAS;PRKCA;TTF2
Oxytocin signaling pathway	Adcy4;PIK3R2;CAMK2A;CACNB2;PRKAA2;PPP1R12B;MAPK1;MAP2K2;CAMK1D
Renin secretion	ORAI1;CLCA1;GNAI2;GNAI1;PDE3A;GNAS;PRKACA;PDE1A;ITPR1
Aldosterone synthesis and secretion	ADCY8;CALML3;NETO2;ITPR3;CREB5;CYP11A1;ADCY3;GNA11;PRKACB
Salivary secretion	ATP1B3;ATP1A4;MUC7;ATP1B2;GUCY1B3;GNAQ;CALM3;CST1;PLCB3
Gastric acid secretion	KCNJ10;PRKACG;KCNJ16;KCNK10;KCNJ15;CALM1;Car2;SLC9A4;CALML5
Pancreatic secretion	PRSS2;ATP1B2;CD38;ATP2A3;SCTR;PLA2G2E;ATP2A1;ATP1B4;TRPC1
Alzheimers disease	CASP12;COX5B;COX6A1;NDUFA13;NDUFV2;NDUFC1;ATP5F1;NDUFA12;PPP3CB
Huntingtons disease	ATP5F1;TBPL1;POLR2J;POLR2C;UQCRC2;NDUFB9;NDUFS8;PLCB2;POLR2G
Proteoglycans in cancer	TNF;BRAF;PRKCG;PIK3R1;CAMK2A;HOXD10;FZD1;PDCD4;HSPB2

ITPR1 has several biochemical functions, for example, calcium channel activity, calcium channel inhibitor activity, inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR1 itself. We selected most functions ITPR1 had, and list some proteins which have the same functions with ITPR1. You can find most of the proteins on our site.

Function	Related Protein
calcium channel activity	CACNA1SB;TRPM2;ORAI1B;PANX1;CACNA1BA;TRPV3;RYR2;PSEN1;TRPC2B
calcium channel inhibitor activity	FKBP1AB;CCDC109B;FKBP1B;TNNI3;SLC30A1B;PHPT1;SLC30A1;AMBP;ITPR1
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ITPR3;ITPR1;ITPR2;AKR1C1
intracellular ligand-gated calcium channel activity	AKR1C1;ITPR3;TRPA1;ITPR1;RYR2
ion channel activity	TRPC4B;KCNA6A;SCN12AB;SCN8AA;GRIA3B;ITPR1;TRPM1A;GRIN2A;FXYD5
phosphatidylinositol binding	SNX17;SNX12;TULP2;SNX18A;NISCH;SGK3;ARHGAP32;SNX4;PLD2
protein C-terminus binding	PIAS3;PRDX3;PHB2;SDCBP;NEFL;VPS36;KCNK3;MID1IP1;DYNLL1
protein binding	OPRD1;LRP5;TEAD2;FRMPD2;HTATIP2;ATXN1L;TRIM40;DDX19A;DEFB121
protein complex binding	PDX1;HTR2A;ADM2;Casp3;VDAC1;RIPK1;BCAP31;CPD;RAP1B
protein phosphatase binding	IRS2;ERBB2;MVP;HSF4;ROS1;CSF1R;CDH5;TRAF2;MAP3K5

ITPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR1.

Erp44; Hspa9; Htt; Vdac1; Aco2; Ppif; Hap1; Hap1; PRKACB; HTT; CALM1; Ywhae; Ywhaz

Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).

Sarachana, T; Hu, VW; et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. MOLECULAR AUTISM 4:-(2013).