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ICOSLG

  • Official Full Name

    inducible T-cell co-stimulator ligand

  • Overview

    Human B7-H2, also called B7RP-1, B7h, LICOS, and GL50, is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1);, PD-L2, and B7-H3. B7 proteins are members of the immunoglobulin (Ig); su
  • Synonyms

    ICOSLG; inducible T-cell co-stimulator ligand; ICOSL; ICOS ligand; B7 homolog 2; B7 homologue 2; B7 H2; B7 related protein 1; B7H2; B7RP 1; B7RP1; CD275; GL50; ICOS L; KIAA0653; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand; B7-H2; LICOS; B7RP-1; ICOS-L;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Homo sapiens (Human)
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus monkey
  • CHO
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human Cell
  • Human cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • mFc
  • 6×His
  • DDK|His
  • Fc
  • Avi
  • hFc
  • hIgG1
  • hIgG4
  • His (Fc)
  • His|T7
  • human|IgG1|Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ICOSLG-1026H Active Recombinant Human ICOSLG Protein, Fc Chimera Mammalian cells Fc
Human ICOSLG-179H Active Recombinant Human ICOSLG, Fc-tagged CHO Fc
Human ICOSLG-1213H Active Recombinant Human ICOSLG, MIgG2a Fc-tagged CHO Fc
Human ICOSLG-3213H Active Recombinant Human ICOSLG protein, His-tagged HEK293 His Met 1-Ser 258
Human ICOSLG-1027H Active Recombinant Human ICOSLG Protein, His-tagged HEK293 His Asp19-Ser258
Human ICOSLG-1215H Active Recombinant Human ICOSLG, HIgG1 Fc-tagged CHO Fc
Human ICOSLG-1214H Active Recombinant Human ICOSLG, HIgG1 Fc-tagged, mutant CHO Fc
Human ICOSLG-539H Active Recombinant Human ICOSLG, His-tagged, Biotinylated Human Cell His
Human ICOSLG-540H Active Recombinant Human ICOSLG, His-tagged Human Cell His
Human ICOSLG-541H Active Recombinant Human ICOSLG, Fc-tagged, Biotinylated Human Cell Fc
Human ICOSLG-051H Active Recombinant Human ICOSLG protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Ala19-Thr139
Human ICOSLG-053H Active Recombinant Human ICOSLG protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Asp19-Ser258
Human ICOSLG-169H Recombinant Human ICOSLG Protein HEK293 N/A Asp19-Ser258
Human ICOSLG-2143H Recombinant Human Inducible T-cell Co-stimulator Ligand, Fc Chimera Mammalian Cell Fc
Human ICOSLG-168H Recombinant Human ICOSLG Protein, DDK/His-tagged HEK293 DDK/His Asp19 – Ser258
Human ICOSLG-7689H Recombinant Human ICOSLG protein, His & T7-tagged E.coli His/T7 Lys23~Thr249 (Accession # O75144)
Human ICOSLG-425H Recombinant Human ICOSLG protein, Fc-tagged HEK293 human/IgG1/Fc Asp19-Ser258
Human ICOSLG-1095HCL Recombinant Human ICOSLG cell lysate Human Cell N/A
Human ICOSLG-3213HAF488 Recombinant Human ICOSLG Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Asp19-Ser258
Human ICOSLG-144HB Recombinant Human ICOSLG protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Asp19-Ser258
Human ICOSLG-794H Recombinant Human ICOSLG Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ICOSLG-947HG Active GMP Recombinant Human ICOSLG protein HEK293 DNA sequence encoding Human B7-H2 (NP_056074.1) was expressed with His tag at the C-terminal.
Human ICOSLG-3213HF Recombinant Human ICOSLG Protein, His-tagged, FITC conjugated HEK293 His Asp19-Ser258
Human ICOSLG-2859H Recombinant Human ICOSLG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ICOSLG-152H Recombinant Human ICOSLG Protein, His-tagged Human cells His
Human ICOSLG-144H Recombinant Human ICOSLG protein, His-Avi-tagged HEK293 His-Avi Asp19-Ser258
Human ICOSLG-3213HB Recombinant Human ICOSLG protein, His-tagged, Biotinylated HEK293 His
Human ICOSLG-3349H Recombinant Human ICOSLG protein, His-tagged E.coli His 1-302 aa
Human ICOSLG-039H Recombinant Human ICOSLG Protein, His-tagged E.coli His
Human ICOSLG-425HAF488 Recombinant Human ICOSLG Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Asp19-Ser258
Human ICOSLG-2935H Active Recombinant Human ICOSLG protein, Fc-tagged HEK293 Fc Asp 19-Ser 258
Human ICOSLG-3213HAF555 Recombinant Human ICOSLG Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Asp19-Ser258
Human ICOSLG-90H Recombinant Human ICOSLG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ICOSLG-598H Recombinant Human ICOSLG Protein HEK293 302
Human ICOSLG-0119H Recombinant Human ICOSLG Protein (Met1-Ser258), C-His-tagged Mammalian cells C-His Met1-Ser258
Human ICOSLG-425HAF555 Recombinant Human ICOSLG Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Asp19-Ser258
Human ICOSLG-90H-B Recombinant Human ICOSLG Protein Pre-coupled Magnetic Beads HEK293
Human ICOSLG-3522H Recombinant Human ICOSLG Protein (Asp19-Ser258), C-His tagged Mammalian cells C-His Asp19-Ser258
Human ICOSLG-533H Recombinant Human ICOSLG Protein (Asp19-Thr256), C-mFc and 6×His-tagged HEK293 C-mFc and 6×His Asp19-Thr256
Human ICOSLG-3213HAF647 Recombinant Human ICOSLG Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Asp19-Ser258
Human ICOSLG-4141H Recombinant Human ICOSLG Protein (Met1-Ser259), C-His tagged Mammalian cells C-His Met1-Ser259
Human ICOSLG-425HAF647 Recombinant Human ICOSLG Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Asp19-Ser258
Human ICOSLG-425HF Recombinant Human ICOSLG Protein, hFc-tagged, FITC conjugated HEK293 hFc Asp19-Ser258
Human ICOSLG-0728H Recombinant Human ICOSLG Protein (Lys23-Thr249), N-His tagged E.coli N-His Lys23-Thr249
Mouse Icoslg-877M Recombinant Mouse Icoslg protein, Fc-tagged HEK293 human/IgG1/Fc Glu47-Lys279
Rat Icoslg-290R Recombinant Rat Icoslg protein, His-tagged HEK293 His Met1-Lys261
Rat ICOSLG-967R Active Recombinant Rat ICOSLG protein, hFc-tagged HEK293 hFc Met1-Lys261
Rat ICOSLG-2933R Active Recombinant Rat ICOSLG protein, Fc-tagged HEK293 Fc Glu 25-Lys 261
Monkey ICOSLG-1232CAF647 Recombinant Cynomolgus ICOSLG Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 249
Monkey ICOSLG-1232CAF555 Recombinant Cynomolgus ICOSLG Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 249
Monkey ICOSLG-1232CF Recombinant Cynomolgus ICOSLG Protein, His-tagged, FITC conjugated HEK293 His 249
Monkey ICOSLG-1232CAF488 Recombinant Cynomolgus ICOSLG Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 249
Rhesus monkey ICOSLG-1514R Recombinant Rhesus Monkey ICOSLG Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey ICOSLG-1515R Recombinant Rhesus Monkey ICOSLG Protein, hIgG4-tagged HEK293 hIgG4
Cynomolgus ICOSLG-291C Active Recombinant Cynomolgus ICOSLG protein, His-tagged HEK293 His Met1-Thr256
Cynomolgus ICOSLG-2934C Active Recombinant Cynomolgus ICOSLG protein, Fc-tagged HEK293 Fc Asp 19-Thr 256
Cynomolgus ICOSLG-1009C Recombinant Cynomolgus ICOSLG protein, Fc-tagged HEK293 human/IgG1/Fc Asp19-Thr256
Homo sapiens (Human) RFL36461HF Recombinant Full Length Human Icos Ligand(Icoslg) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-302)
Chicken ICOSLG-6641C Recombinant Chicken ICOSLG Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ICOSLG Related Articles

ICOSLG involved in several pathways and played different roles in them. We selected most pathways ICOSLG participated on our site, such as Cell adhesion molecules (CAMs), Intestinal i, ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICOSLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)F11R.1;NLGN2A;VTCN1;H2-Q10;HLA-DOB;LRRC4;CLDNK;ICAM3;PVRL1
Intestinal iH2-AB1;CCL28;HLA-DQA2;BMA1;CD40;CCL25;CCR10;HLA-DPB1;CCR9A
ne network for IgA productionHLA-DRB5;MHC2DCB;HLA-DRB1;BMA2;TGFB1A;CD86;CCR9A;HLA-DRB4;HLA-DQA1

ICOSLG has several biochemical functions, for example, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICOSLG itself. We selected most functions ICOSLG had, and list some proteins which have the same functions with ICOSLG. You can find most of the proteins on our site.

Function Related Protein
receptor bindingCHRNA10;IL1RAPL1;GSTM7;PVRL1B;FGF18A;PRDX5;ANXA1;ADCYAP1;FYB

ICOSLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICOSLG here. Most of them are supplied by our site. Hope this information will be useful for your research of ICOSLG.

Sakthivel, P; Gereke, M; et al. Attenuation of Immune-Mediated Influenza Pneumonia by Targeting the Inducible Co-Stimulator (ICOS) Molecule on T Cells. PLOS ONE 9:-(2014).
Fan, XZ; Quezada, SA; et al. Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy. JOURNAL OF EXPERIMENTAL MEDICINE 211:715-725(2014).
  • Q&As
  • Reviews

Q&As (6)

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How to evaluate the role of icosg proteins in the immune system? 10/06/2022

ICOSLG protein plays an important regulatory role in the immune system. It binds to ICOS receptors on the surface of T cells and promotes the activation and differentiation of T cells, which in turn affects the strength and direction of the immune response.

Which biomolecules can be used as molecular markers for ICOSLG proteins? 02/25/2022

Certain biomolecules can serve as molecular markers of ICOSLG proteins, such as mRNAs or proteins of ICOSLG proteins detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

What factors need to be considered in drug development for ICOSLG proteins? 12/10/2020

Factors to be considered in drug development for ICOSLG proteins include drug specificity, safety, pharmacokinetic properties, etc. In addition, the dosage form, route of administration, and dosage of the drug need to be considered to develop an effective treatment plan.

What factors can affect the expression of ICOSLG protein? 06/09/2020

A variety of factors can affect the expression of ICOSLG protein, including cytokines, inflammatory factors, immunostimulants, etc. These factors can stimulate or inhibit the expression of ICOSLG protein, which in turn affects the strength and direction of the immune response.

What are the therapeutic strategies for ICOSLG protein? 05/06/2020

Therapeutic strategies targeting ICOSLG proteins include inhibition of its activity, modulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against ICOSLG protein to inhibit its aberrant activity in disease, or the regulation of ICOSLG protein expression through gene knockout or overexpression technology.

How to evaluate the potential of ICOSLG protein as a drug target? 02/21/2020

Assessing the potential of ICOSLG proteins as drug targets requires a comprehensive analysis. Factors to consider include the structure and function of the ICOSLG protein, its role in the immune system, interactions with existing medications, and potential therapeutic efficacy and safety.

Customer Reviews (3)

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Reviews
12/17/2022

    ICOSLG performed very well in the experiments, with reliable and reproducible results.

    11/14/2021

      The stability is very strong, and it can maintain the stability of its structure and function even after a lot of use, which shows its excellent quality and reliability.

      06/30/2020

        The storage conditions are simple, and it will not be denatured even at ultra-low temperatures.

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