IDUA
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Official Full Name
iduronidase, alpha-L-
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Overview
This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). -
Synonyms
IDUA; iduronidase, alpha-L-; alpha-L-iduronidase; MPS1; Alpha L iduronidase; IDA; Iduronidase alpha L;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Therapeutic Proteins
- Chicken
- Human
- Mouse
- CHO
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Yeast
- Flag
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- IDUA Related Articles
IDUA involved in several pathways and played different roles in them. We selected most pathways IDUA participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDUA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan degradation | GALNS;GNSA;SPAM1;IDS;HYAL6;HYAL4;HPSE2;HYAL1;GLB1 |
| Metabolic pathways | RDH10;CBR2;GBGT1L4;B3GNT6;NT5C2A;CYP26C1;B4GALT6;MTR;NDUFB4 |
| Lysosome | GGA3;ATP6V0A4;AP4S1;NAGA;NAPSA;CTNS;ASAH1;PSAPL1;GNS |
IDUA has several biochemical functions, for example, L-iduronidase activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDUA itself. We selected most functions IDUA had, and list some proteins which have the same functions with IDUA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-iduronidase activity | |
| receptor binding | IDUA;NUDT7;ACOT2;CNPY4;TMEM38A;PTK2BB;ALCAM;FZD8;TNFSF13 |
IDUA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDUA here. Most of them are supplied by our site. Hope this information will be useful for your research of IDUA.
MPP3
- Q&As
- Reviews
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