IL18R1
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Official Full Name
interleukin 18 receptor 1
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Overview
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to -
Synonyms
IL18R1; interleukin 18 receptor 1; interleukin-18 receptor 1; CD218 antigen-like family member A; CD218a; CDw218a; CDw218a antigen; IL 1Rrp; IL-18R-1; IL-18R1; IL-1Rrp; IL1 receptor related protein; IL1 receptor-related protein; IL18R_HUMAN; IL18RA; Il18ralpha; IL1R-rp; IL1RRP; Interleukin 18 receptor, alpha chain; interleukin 1 receptor related protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Antibody
- Canine
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Mammalian cells
- Rabbit
- C
- His
- Fc
- Fc|His
- Avi
- hFc
- His (Fc)
- human|IgG1|Fc
- N/A
- N
- GST
- Involved Pathway
- Protein Function
- Interacting Protein
- IL18R1 Related Articles
- IL18R1 Related Gene Family
- IL18R1 Related Research Area
IL18R1 involved in several pathways and played different roles in them. We selected most pathways IL18R1 participated on our site, such as Cytokine-cytokine receptor interaction, TNF signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | IL22RA2;IL18;CXCL12B;TNFSF14;TGFB1A;KITLGB;GH2;BMP7A;TNFRSF18 |
TNF signaling pathway | PIK3CG;TRAF1;VEGFC;DNM1L;LIF;RELA;RPS6KA4;CCL5;PGAM5 |
Inflammatory bowel disease (IBD) | RELA;IL13;IL12RB2;IL1B;HLA-DQA1;STAT3;HLA-DRA;NFKB1;HLA-DRB5 |
IL18R1 has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-18 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18R1 itself. We selected most functions IL18R1 had, and list some proteins which have the same functions with IL18R1. You can find most of the proteins on our site.
Function | Related Protein |
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interleukin-1 receptor activity | IL1RAPL2;IL1R1;IL1R2;IL1RAP;IL18R1;IL1RL2;IL1RAPL1A;IL1RL1 |
interleukin-18 receptor activity | |
protein binding | ECE1;PPARA;KMT2E;C7orf25;TLE3A;GTF3C5;G6PD;BFSP2;MRC1 |
receptor activity | CMKLR1;NEO1;CD46;PAQR4;GRIA3A;DERL1;TNFRSF13B;THRAP3;PAQR9 |
IL18R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18R1.
IL18
- Q&As
- Reviews
Q&As (10)
Ask a questionCo-immunoprecipitation, co-receptor binding assays, and functional studies unveil the cooperative roles of IL18R1 and IL18RAP in signaling.
Fluorescence microscopy, confocal imaging, and super-resolution microscopy visualize IL18R1 dynamics and clustering upon IL18 stimulation.
Mass spectrometry, phosphorylation assays, and ubiquitination studies investigate IL18R1 post-translational modifications.
Disease model assessments, patient sample analyses, and pharmacological interventions explore IL18R1's involvement in diseases and therapeutic potential.
RT-qPCR, flow cytometry, and single-cell RNA sequencing assess IL18R1 expression across different cell types and physiological states.
Knockout models, siRNA-mediated knockdown, and CRISPR/Cas9 gene editing reveal the physiological roles of IL18R1 in vivo and in vitro.
Western blotting, ELISAs, and phosphoprotein analyses decipher IL18R1-mediated signaling cascades and cytokine production.
Site-directed mutagenesis, chimera studies, and domain swapping experiments dissect the functional contributions of IL18R1's domains.
X-ray crystallography, cryo-electron microscopy, and molecular dynamics simulations elucidate the structural basis of IL18R1-IL18 recognition and activation.
Surface plasmon resonance, bio-layer interferometry, and kinetic binding assays quantify IL18R1-IL18 interactions.
Customer Reviews (3)
Write a reviewLow endotoxin levels.
Good for flow cytometry.
Potent in Th1 activation.
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