Il28b
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Official Full Name
interleukin 28B
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Overview
Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29. Their classification as Interferons is due to their ability to induce an antiviral state, while their additional classification as cytokines is due to their chromosomal location as well as the fact that they are encoded by multiple exons, as opposed to a single exon, as most type-I IFNs are. -
Synonyms
Cytokine Zcyto20;IFN lambda 2;IFNL2;IL28A;Interferon lambda 2;Interleukin 28A;ZCYTO20;Il28; IFL-1; IL-28B; INF-alpha; INF-lambda; interleukin-28B; IFN-lambda-3; interleukin 28; interferon alpha; interferon lambda-3; Il28b; interleukin 28B;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Equine
- Human
- Mouse
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Yeast
- C
- His
- His (Fc)
- Avi
- His|Myc
- N/A
- N
- Il28b Related Articles
- Il28b Related Gene Family
- Il28b Related Research Area
Il28b involved in several pathways and played different roles in them. We selected most pathways Il28b participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Il28b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Il28b has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Il28b itself. We selected most functions Il28b had, and list some proteins which have the same functions with Il28b. You can find most of the proteins on our site.
| Function | Related Protein |
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Il28b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il28b here. Most of them are supplied by our site. Hope this information will be useful for your research of Il28b.
- Q&As
- Reviews
Q&As (6)
Ask a questionIL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.
IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.
The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.
The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.
The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.
IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.
Customer Reviews (3)
Write a reviewActivity retention time is very long and can be maintained for a long time.
High cost performance and low preparation cost.
It has a wide range of applications and can be used in various biological experiments.
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