ITGB3
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Official Full Name
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
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Overview
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. -
Synonyms
GT; CD61; GP3A; BDPLT2; GPIIIa; integrin beta-3; platelet glycoprotein IIIa; platelet membrane glycoprotein IIIa; CD41; CD41b; GP 2B; GP IIb; GTA; HPA3; Integrin alpha 2b; ITGA2B; ITGB3; Tadocizumab; 339086-80-5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human cells
- Human plasma
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- C
- His
- Strep
- DYKDDDDK
- Flag
- His (Fc)
- Avi
- His|Avi
- His|S
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ITGB3 Related Articles
ITGB3 involved in several pathways and played different roles in them. We selected most pathways ITGB3 participated on our site, such as Rap signaling pathway, Phagosome, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | FPR1;PFN2;MAPK1;LPAR5;FGFR4;FGF12;ITGA2B;FLT4;CALM4 |
| Phagosome | BMA1;ITGAM;MHC2DCB;TFRC;SCARB1;SEC61A1;MHC1UEA;HLA-DRB3;MHC2A |
| PIK-Akt signaling pathway | ITGB6;PIK3R5;GRB2;FGF6;COL27A1;CD19;ITGA5;VTN;RXRA |
| Osteoclast differentiation | CSF1R;CSF1;NCF4;PIK3R1;MAPK10;LILRB4;SFPI1;PIK3CD;IFNG |
| Focal adhesion | KDRL;PIK3R1;TNK2;RAP1B;THBS4A;COL6A3;Reln;ITGB1B.2;ERBB2 |
| ECM-receptor interaction | ITGA3;CD47;ITGA9;COL11A2;ITGA1;ITGA5;Reln;ITGA8;COL27A1 |
| Platelet activation | PLCB3;GNAQ;PRKG1;PPP1CB;GP5;MYL12B;PIK3R2;PPP1CA;SNAP23 |
| Hematopoietic cell lineage | CD3D;THPO;CD1B;CD9;Il6ra;CD19;GM13305;IL4;HLA-DRA |
| Regulation of actin cytoskeleton | CHRM2A;ARHGAP35;MAPK3;IQGAP3;MYL2B;FGF19;FGF8A;FGF11A;PXN |
| Thyroid hormone signaling pathway | MED1;TP53;PLN;NOTCH4;PRKACG;PLCB4;NOTCH3;PLCB1;MED24 |
| Proteoglycans in cancer | WNT8B;PLAU;ELK1;MAPK1;TWIST1;PTK2;TLR2;HSPG2;HIF1A |
| MicroRNAs in cancer | RECK;PTEN;HDAC4;WNT3;BMPR2;APC;TRP63;NOTCH2;CDC25A |
| Hypertrophic cardiomyopathy (HCM) | RYR2;ITGB7;PRKAB1;TNNC1;IGF1;ITGA4;ITGB5;TPM4;Itga10&Itgb1 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CTNNA3;ITGA6;ATP2A2;ITGA7;ITGA8;DAG1;TCF7L2;ACTN4;CACNB2 |
| Dilated cardiomyopathy | TGFB3;SGCA;TGFB2;CACNG6;IGF1;CACNA2D4;MYH7;CACNG7;ITGB8 |
ITGB3 has several biochemical functions, for example, cell adhesion molecule binding, enzyme binding, extracellular matrix binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB3 itself. We selected most functions ITGB3 had, and list some proteins which have the same functions with ITGB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesion molecule binding | POSTN;PVRL4;NRXN3;NRXN2;CDH1;GLYCAM1;ADAM8;SMAGP;NLGN4X |
| enzyme binding | HDHD2;PHB;Alb;HSPA6;EIF4E;PICK1;TAF10;MST1R;CD40 |
| extracellular matrix binding | CYR61;SPARC;ITGAV;GPR56;ITGA2B;BGN;SPP1;SPOCK2;DCN |
| fibronectin binding | FSTL3;IGFBP5A;FBLN1;THBS1;CTSK;CTSL1;CCDC80;CTSS;MFAP2 |
| identical protein binding | DAPK1;MAP3K11;IFI203;PDGFB;VWF;DRG1;PRDX1;PHC2;STK10 |
| platelet-derived growth factor receptor binding | PDGFAA;FIGF;PDGFRA;ITGB3;PTEN;Pdgfa&Pdgfb;PDGFA;LYN;IL1R1 |
| protease binding | BRCA2;POLG;PYCARD;Serpina1c;ALPI;PEO1;LCN2;LDLR;SERPINA1D |
| protein binding | LRRC4B;ALDH7A1;CTSG;SYNPO2L;CHMP4C;SEPHS1;BAG3;PLOD3;DICER1 |
| protein disulfide isomerase activity | GLRX2;PDIP5;TXNDC11;TMX3;P4HB;PDIA6;TMX1;TXNDC5;ZNF169 |
| vascular endothelial growth factor receptor 2 binding | ITGB3;PDCL3;VEGFA;GREM1;ITGA5 |
| virus receptor activity | F11R;ITGB3;SLC20A2;GYPA;TYRO3;ACE2;IDE;CXCR4;CLEC4M |
ITGB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB3.
ITGAV; ITGA2B
- Q&As
- Reviews
Q&As (5)
Ask a questionITGB3 is mainly found on the surface of PLT and megakaryocytes.
ITGB3 is involved in the regulation of embryonic development, wound healing, coagulation and hemostasis, and immune response.
ITGB3 is strongly associated with research into diseases such as colon and prostate cancer.
There are two types of ITGB3, αvβ3 and αIIbβ3.
ITGB3 deficiency led to reduced differentiation of circulating angiogenic cells, as well as reduced adhesion to the subendothelial membrane of injured endothelial cells, the unable to bind to fibrinogen, increasing the risk of vascular leakage or bleeding.
Customer Reviews (3)
Write a reviewThe technician modified my experimental protocol so that my experiment went smoothly.
Very good after-sales service to get my experiments going!
The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.
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