KAT5
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Official Full Name
K(lysine) acetyltransferase 5
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Overview
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] -
Synonyms
KAT5; K(lysine) acetyltransferase 5; TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1; histone acetyltransferase KAT5; K-acetyltransferase 5; cPLA2 interacting protein; cPLA(2)-interacting protein; 60 kDa Tat-interactive protein; Tat interacting protein, 60kDa; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein, 60kDa;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- KAT5 Related Research Area
KAT5 involved in several pathways and played different roles in them. We selected most pathways KAT5 participated on our site, such as ATF-2 transcription factor network, Androgen receptor signaling pathway, C-MYC pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ATF-2 transcription factor network | MAPK14;CREB1;JDP2;JUN;JUND;GADD45A;DUSP1;JUNB;CDK4 |
| Androgen receptor signaling pathway | ZMIZ1;DSTN;PATZ1;CREBBP;RHOB;RNF14;RAD54L2;SMARCE1;KAT7B |
| C-MYC pathway | MYC;HBP1;RUVBL2;ACTL6A;KAT5 |
| Cell Cycle | SDCCAG8;NDC80;MYCA;MAD1L1;SFN;POLD3;DCTN1;FAM175A;TSGA14 |
| Cell Cycle Checkpoints | DBF4;BARD1;HUS1;BRCC3;MCM10;RAD9;RAD1;RAD50;TP53BP1 |
| Cellular Senescence | SUZ12B;H3F3B.1;TERF2;HIST4H4;CEBPB;EHMT2;CBX6A;HIST1H1E;SCMH1 |
| Cellular responses to stress | KIAA1967;HBXIP;TINF2;ST13;RB1CC1;WDR45;RRAGA;ATG101;CDKN2C |
| Chromatin modifying enzymes | KDM1A;WDR77;ELP4;HIST2H3C;KDM1B;KDM5D;SMARCB1;SMARCE1;HMG20B |
KAT5 has several biochemical functions, for example, acetyltransferase activity, androgen receptor binding, histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT5 itself. We selected most functions KAT5 had, and list some proteins which have the same functions with KAT5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetyltransferase activity | CREBBP;KAT6B;KAT2B;MBOAT7;HHAT;MBOAT1;LPCAT3;Acnat1;CML5 |
| androgen receptor binding | PIAS2;PRKCBB;CDK7;PIAS1;RNF6;TCF21;PRPF6;RB1;PRMT2 |
| histone acetyltransferase activity | KAT7A;NCOA1;KAT7B;CSRP2BP;METTL8;MED24;CDYL;MGEA5;KAT2A |
| contributes_to histone acetyltransferase activity | TAF12;TAF6L;KAT5;KAT2A;TEX30;TAF9;SAP130;SUPT3H;TADA3 |
| metal ion binding | CSHL1;RYBPA;ZHX1;TRIM27;ZFP750;ME2;MICAL2B;ZNF566;ZNF560 |
| protein binding | FYN;GPN1;CCDC9;PLIN5;SARM1;ESR1;POLDIP3;DPM1;CHEK2 |
| repressing transcription factor binding | NOC2L;MAGEA2;TLE4;TBP;CTBP1;EIF4E;SRI;HDAC5;CBX5 |
| transcription coactivator activity | PSMD9;TAF5L;TAF7;VGLL1;USP16;MTF1;RB1;E4F1;ESR2 |
KAT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT5.
MRGBP; ZBTB8A; RUVBL1; Myod1; CBX8
- Q&As
- Reviews
Q&As (7)
Ask a questionIt acetylates histone H4, affecting chromatin structure.
Certain cancers have identified mutations in KAT5.
KAT5 regulates gene expression via histone acetylation.
It plays a key role in repairing DNA double-strand breaks.
Dysregulation of KAT5 is linked to cancer development.
Therapies are being developed to modulate KAT5 in cancer and neurodegenerative diseases.
KAT5 is located in both the nucleus and cytoplasm.
Customer Reviews (3)
Write a reviewProduct arrived quickly, perfect.
Reliable for experiments, quality.
Great quality, worked well.
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