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KCNH1

  • Official Full Name

    potassium voltage-gated channel, subfamily H (eag-related), member 1

  • Overview

    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
  • Synonyms

    KCNH1; potassium voltage-gated channel, subfamily H (eag-related), member 1; potassium voltage-gated channel subfamily H member 1; eag; eag1; h eag; Kv10.1; Voltage gated potassium channel subunit Kv10.1; MGC124420; MGC142269; EAG channel 1; Ether a go go potassium channel 1; Ether-a-go-go potassium channel 1; h-eag; hEAG1; KCNH1_HUMAN; M eag; MGC124419; Potassium voltage gated channel subfamily H (eag related), member 1; Voltage-gated potassium channel subunit Kv10.1; OTTHUMP00000034451; OTTHUMP00000034569; ether-a-go-go, Drosophila, homolog of;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Rhesus Macaque
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KCNH1-29891TH Recombinant Human KCNH1 Wheat Germ N/A 99 amino acids
Human KCNH1-5060HCL Recombinant Human KCNH1 293 Cell Lysate HEK293 N/A
Rat KCNH1-3182R Recombinant Rat KCNH1 Protein Mammalian Cell His
Rat KCNH1-2838R Recombinant Rat KCNH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KCNH1-2838R-B Recombinant Rat KCNH1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque KCNH1-2353R Recombinant Rhesus monkey KCNH1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque KCNH1-2174R Recombinant Rhesus Macaque KCNH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque KCNH1-2174R-B Recombinant Rhesus Macaque KCNH1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

KCNH1 involved in several pathways and played different roles in them. We selected most pathways KCNH1 participated on our site, such as Neuronal System, Potassium Channels, Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuronal SystemPANX1A;PPFIA1;KCNH5A;KCNJ1A.1;KCNQ1;CHRNA7;KCNJ1A.2;CHRNA2;KCNS2
Potassium ChannelsKCNAB2B;KCNMB1;KCNK18;KCNK2B;KCNS3;KCNS3A;KCNMB2;KCNH6;KCNJ1A.6
Voltage gated Potassium channelsKCNAB2B;KCND3;KCNC3A;KCNQ2A;KCNC4;KCNC1B;KCNQ3;KCNA10;KCNH2A

KCNH1 has several biochemical functions, for example, 14-3-3 protein binding, calmodulin binding, NOT cyclic nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH1 itself. We selected most functions KCNH1 had, and list some proteins which have the same functions with KCNH1. You can find most of the proteins on our site.

Function Related Protein
14-3-3 protein bindingPRKCE;HDAC7;PRKCZ;KIF13B;AANAT;IRS2;HDAC7A;AKT1;ZFP36
calmodulin bindingMKNK2B;PDE1A;RIT2;CAMKK2;MKNK1;CNN3;CAMK2G;CASK;TRPC2
NOT cyclic nucleotide binding
delayed rectifier potassium channel activityKCNA5;KCND1;KCNC1B;KCNG4A;KCNA1;KCNA2;KCNH1;KCNE1;KCNC3A
ion channel bindingKCND3;CTNNB1;LYN;KCNB2;YWHAH;NEDD4L;YES1;RNF207;SRI
phosphorelay sensor kinase activityKCNH5A;CASS4;KCNH1A;KCNH1;KCNH5;KCNH8;KCNH1B;KCNH2
protein bindingBTG1;HTN1;SSX2;GPR37L1;FAS;SLC9A3R1;KRT7;STT3A;PALB2
protein heterodimerization activityTGFB2;PBX1;HOMER1;HIST1H4J;TAF4B;MEF2A;ALX4;IKZF4;SUPT5H
protein kinase bindingCDH2;CDK5;PTEN;RPTOR;RB1CC1;LAT;CCNL1A;AURKA;CLTC

KCNH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH1.

CALM1; SDCBP; FASTKD5; WDYHV1; S100B; Rabep1; Kcnh1; RAB7A

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