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KCNJ8

  • Official Full Name

    potassium inwardly-rectifying channel, subfamily J, member 8

  • Overview

    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.
  • Synonyms

    KCNJ8; potassium inwardly-rectifying channel, subfamily J, member 8; ATP-sensitive inward rectifier potassium channel 8; Kir6.1; inward rectifier K(+) channel Kir6.1; inwardly rectifying potassium channel KIR6.1; potassium channel, inwardly rectifying sub;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KCNJ8-260H Recombinant Human KCNJ8, GST-tagged E.coli GST 181-424aa
Human KCNJ8-5043HCL Recombinant Human KCNJ8 293 Cell Lysate HEK293 N/A
Mouse KCNJ8-8522M Recombinant Mouse KCNJ8 Protein Mammalian Cell His
Mouse Kcnj8-3760M Recombinant Mouse Kcnj8, His-tagged E.Coli or Yeast His 424
Mouse KCNJ8-4743M-B Recombinant Mouse KCNJ8 Protein Pre-coupled Magnetic Beads HEK293
Mouse KCNJ8-4743M Recombinant Mouse KCNJ8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KCNJ8-3204R Recombinant Rat KCNJ8 Protein Mammalian Cell His
Rat KCNJ8-2860R Recombinant Rat KCNJ8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KCNJ8-2860R-B Recombinant Rat KCNJ8 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL13675HF Recombinant Full Length Human Atp-Sensitive Inward Rectifier Potassium Channel 8(Kcnj8) Protein, His-Tagged E.coli expression system His Full Length (1-424)
Mus musculus (Mouse) RFL322MF Recombinant Full Length Mouse Atp-Sensitive Inward Rectifier Potassium Channel 8(Kcnj8) Protein, His-Tagged E.coli expression system His Full Length (1-424)
Rattus norvegicus (Rat) RFL30252RF Recombinant Full Length Rat Atp-Sensitive Inward Rectifier Potassium Channel 8(Kcnj8) Protein, His-Tagged E.coli expression system His Full Length (1-424)
Rhesus Macaque KCNJ8-2361R Recombinant Rhesus monkey KCNJ8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque KCNJ8-2182R Recombinant Rhesus Macaque KCNJ8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque KCNJ8-2182R-B Recombinant Rhesus Macaque KCNJ8 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish KCNJ8-3266Z Recombinant Zebrafish KCNJ8 Mammalian Cell His
Chicken KCNJ8-5572C Recombinant Chicken KCNJ8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KCNJ8 Related Articles

KCNJ8 involved in several pathways and played different roles in them. We selected most pathways KCNJ8 participated on our site, such as ATP sensitive Potassium channels, Inwardly rectifying K+ channels, Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ATP sensitive Potassium channelsKCNJ8;KCNJ11;ABCC9
Inwardly rectifying K+ channelsKCNJ8;KCNJ1A.4;KCNJ14;KCNJ1A.6;KCNJ1A.1;KCNJ1B;ABCC9;KCNJ1A.3;KCNJ10
Neuronal SystemKCNK7;GLS2B;CHRNE;KCNC3A;KCNA10;CHRNA7;GJC1;KCNJ1A.1;KCNK10B
Potassium ChannelsKCNA7;KCNA2B;KCNAB3;KCNH2;KCNH1A;KCNJ14;KCNN3;KCNB1;KCNAB1A
SIDS Susceptibility PathwaysPOU3F2;MECP2;KCNQ1;RUNX3;PHOX2A;PLP1;CREM;FOXM1;MAZ
cGMP-PKG signaling pathwayATP2A1;RHOA;GNAI1;GUCY1B3;NPR1;CALM1;CREB3L3;CREB3L1;PPP1CC

KCNJ8 has several biochemical functions, for example, ATP binding, ATP-activated inward rectifier potassium channel activity, NOT G-protein activated inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ8 itself. We selected most functions KCNJ8 had, and list some proteins which have the same functions with KCNJ8. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP6V1A;PTK2AA;MYO15;TAOK1;ACSS3;DAPK3;ATP2B2;TAE1;MARS
ATP-activated inward rectifier potassium channel activityKCNJ1;KCNJ1A.1;KCNJ1A.2;KCNJ11L;KCNJ8;KCNJ1A.3;KCNJ1A.4;KCNJ1A.6;KCNJ1A.5
NOT G-protein activated inward rectifier potassium channel activityKCNJ8;KCNJ11;KCNJ11L
inward rectifier potassium channel activityKCNJ1A.4;KCNJ1A.6;KCNJ1B;KCNJ11L;KCNJ16;KCNK6;KCNJ15;KCNJ1A.5;KCNQ5
sulfonylurea receptor bindingHSP90AB1;KCNJ8

KCNJ8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ8.

Li, Q; Chen, M; et al. KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41:748-754(2014).
Qin, LJ; Lv, Y; et al. Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes. GENETICS AND MOLECULAR RESEARCH 12:2990-3002(2013).
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