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KCNMB4

Official Full Name

potassium large conductance calcium-activated channel, subfamily M, beta member 4
Overview

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.
Synonyms

KCNMB4; potassium large conductance calcium-activated channel, subfamily M, beta member 4; calcium-activated potassium channel subunit beta-4; subfamily M subunit beta-4; BK channel subunit beta 4; BK channel subunit beta-4; BKbeta4; Calcium activated potassium channel beta 4 subunit; Calcium activated potassium channel subfamily M subunit beta 4; Calcium activated potassium channel subunit beta 4; Calcium-activated potassium channel; Charybdotoxin receptor subunit beta 4; Charybdotoxin receptor subunit beta-4; Hbeta4; K(VCA)beta 4; K(VCA)beta-4; KCMB4_HUMAN; KCNMB 4; Large conductance calcium dependent potassium ion channel beta 4 subunit; Maxi K channel subunit beta 4; Maxi K channel subunit beta-4; Potassium large conductance calcium activated channel subfamily M beta member 4; Slo beta 4; Slo-beta-4; OTTHUMP00000236251; calcium-activated potassium channel, subfamily M sub;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KCNMB4-274H	Recombinant Human KCNMB4, GST-tagged	E.coli	GST	46-176aa	$319 / 25ug
Human	KCNMB4-5022HCL	Recombinant Human KCNMB4 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	KCNMB4-8541M	Recombinant Mouse KCNMB4 Protein	Mammalian Cell	His		Inquiry
Mouse	KCNMB4-4751M	Recombinant Mouse KCNMB4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	KCNMB4-4751M-B	Recombinant Mouse KCNMB4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	KCNMB4-4432C	Recombinant Chicken KCNMB4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

KCNMB4 involved in several pathways and played different roles in them. We selected most pathways KCNMB4 participated on our site, such as cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNMB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
cGMP-PKG signaling pathway	MYLK;PPP1CB;SLC25A6;MYLK4;VASP;CREB3L1;INS1;ATF4;CALM3
Vascular smooth muscle contraction	PRKCE;PPP1CAA;GNA11A;CALM2A;NPR2;PRKACA;PLCB2;CALM2;PRKACBB
Insulin secretion	GNAS;KCNMB4;Adcy4;PRKCB;RAPGEF4;ATP1A3;CAMK2B;ATP1B4;ADCYAP1

KCNMB4 has several biochemical functions, for example, calcium-activated potassium channel activity, potassium channel regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNMB4 itself. We selected most functions KCNMB4 had, and list some proteins which have the same functions with KCNMB4. You can find most of the proteins on our site.

Function	Related Protein
calcium-activated potassium channel activity	PKD2L1;KCNN1;KCNN4;KCNMB1;KCNMB2;KCNMA1A;KCNMB4;HPN;KCNMA1
potassium channel regulator activity	KCNAB2;AKAP9;DRD2;SGK1;AMIGO1;KCNAB1;KCNE1L;ABCC9;YWHAE
protein binding	ACTB;SPATA7;NISCH;SLC48A1;EFNA1;CHCHD1;TPD52L2;EID1;FZD6

KCNMB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNMB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNMB4.