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KDM2A

  • Official Full Name

    lysine (K)-specific demethylase 2A

  • Overview

    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
  • Synonyms

    KDM2A; lysine (K)-specific demethylase 2A; FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA; lysine-specific demethylase 2A; F-box/LRR-repeat protein 11; CXXC-type zinc finger protein 8; [Histone-H3]-lysine-36 demethylase 1A; F-box and leucine-rich repeat protein 11; jumonji C domain-containing histone demethylase 1A; jmjC domain-containing histone demethylation protein 1A;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • FLAG
  • Flag|Avi
  • GST
  • His
  • His (Fc)
  • Avi
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KDM2A-45H Active Recombinant Human KDM2A protein, FLAG-Avi-tagged Insect Cell Flag/Avi
Human KDM2A-213H Recombinant Human KDM2A, GST-tagged Sf9 Insect Cell GST
Human KDM2A-300H Recombinant Human KDM2A, GST-tagged E.coli GST 374-558aa
Human KDM2A-46H Recombinant Human KDM2A protein, FLAG-tagged Insect Cell FLAG
Human KDM2A-3885H Recombinant Human KDM2A Protein, GST-tagged Wheat Germ GST
Human KDM2A7257H Recombinant Human KDM2A (1-383) Protein
Human KDM2A-4920HF Recombinant Full Length Human KDM2A Protein, GST-tagged In Vitro Cell Free System GST 782 amino acids
Human KDM2A-0527H Recombinant Human KDM2A Protein (R567-S681), Tag Free E.coli No tag R567-S681
Human KDM2A-0528H Recombinant Human KDM2A Protein (R567-S681), His tagged E.coli His R567-S681
Rhesus Macaque KDM2A-2381R Recombinant Rhesus monkey KDM2A Protein, His-tagged Mammalian Cell His
Rhesus Macaque KDM2A-2202R Recombinant Rhesus Macaque KDM2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque KDM2A-2202R-B Recombinant Rhesus Macaque KDM2A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KDM2A Related Articles

KDM2A involved in several pathways and played different roles in them. We selected most pathways KDM2A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesSMARCD1;PHF8;ING5;SUZ12B;SUZ12A;VPS72;DNMT3A;MBD3;SMARCC2
Chromatin organizationGATAD2A;CAPNS2;CSRP2BP;ELP2;PHF15;KDM3A;KAT8;KDM6B;BRPF3
HDMs demethylate histonesKDM4A;KDM1A;KDM5B;KDM5A;KDM5D;JHDM1D;PHF8;KDM4D;KDM4B

KDM2A has several biochemical functions, for example, histone demethylase activity (H3-K36 specific), unmethylated CpG binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM2A itself. We selected most functions KDM2A had, and list some proteins which have the same functions with KDM2A. You can find most of the proteins on our site.

Function Related Protein
histone demethylase activity (H3-K36 specific)KDM2A;KDM2B;JHDM1D;PHF8;KDM4A;KDM8;C14orf169;JMJD5
unmethylated CpG bindingDNMT3B;MLL1;DNMT3A;CXXC1;KDM2A
zinc ion bindingMARCH4;SIRT6;CIZ1B;RBM4;RFWD2;MICALL2;PML;LIN28B;KDM2B

KDM2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM2A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM2A.

h3_peptide_31-41; SKP1; SMAD7; FOS; ENO1; UBE2G2; SMAD3; phnP; FBXO32; ZNF512B; CBX4; BCL6; RAB5C; Cbx1; REEP5; KIF20B; Chmp4c; Skp1

Kawakami, E; Tokunaga, A; et al. The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. MECHANISMS OF DEVELOPMENT 135:31-42(2015).
Huang, YF; Liu, YQ; et al. Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer. TUMOR BIOLOGY 36:271-278(2015).
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