KDM4A
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Official Full Name
lysine (K)-specific demethylase 4A
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Overview
The methylation state of lysine residues in histone proteins is a major determinant of the formation of active and inactive regions of the genome and is crucial for proper programming of the genome during development (1,2). Jumonji C (JmjC) domain-contain -
Synonyms
KDM4A; lysine (K)-specific demethylase 4A; JMJD2, JMJD2A, jumonji domain containing 2 , jumonji domain containing 2A; lysine-specific demethylase 4A; JHDM3A; jumonji C domain containing histone demethylase 3A; KIAA0677; jumonji domain containing 2; jumo;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- StepII
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- KDM4A Related Articles
- KDM4A Related Research Area
KDM4A involved in several pathways and played different roles in them. We selected most pathways KDM4A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | SMARCA4;HIST2H3C;KANSL3;BRMS1;EED;ELP3;ARID4A;SMARCD3B;C3orf75 |
| Chromatin organization | C17orf81;EP400;VPS72;ARID1A;EPC1;SMARCC2;GATAD2B;ARID2;KDM6AL |
| DNA Double Strand Break Response | EYA4;THRSP;KDM4A;TP53BP1;SMARCA5;HTATIP;UBE2V2;BAZ1B;BABAM1 |
| DNA Double-Strand Break Repair | RAD50;THRSP;PAXIP1;TDP2B;UIMC1;FAM175A;KDM4B;HUS1;BAZ1B |
| DNA Repair | ZBTB32;RTEL1;HUS1;MGMT;INO80C;INO80;NFRKB;USP10;RNF111 |
| HDMs demethylate histones | KDM2AA;KDM2B;KDM1B;KDM4A;KDM5A;KDM4B;KDM7AB;PHF2;KDM5D |
| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | KDM4A;EYA4;BAZ1B;EYA3;EYA2;KDM4B |
KDM4A has several biochemical functions, for example, histone demethylase activity (H3-K36 specific), methylated histone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM4A itself. We selected most functions KDM4A had, and list some proteins which have the same functions with KDM4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone demethylase activity (H3-K36 specific) | JHDM1D;KDM8;JMJD5;KDM2B;PHF8;KDM2A;C14orf169;KDM4A |
| methylated histone binding | KAT8;ING2;PHF13;SPIN1;JHDM1D;CHD1;CAPNS2;CBX7;UHRF1 |
| protein binding | FCGR2C;ADPRH;BSCL2;REEP5;ACYP2;XRCC4;NOP58;TRIM22;BEND3 |
| ubiquitin protein ligase binding | FLJ11011L;NKD2;NAE1;MUL1;XBP1;UBE2H;NGFR;UBE2N;BID |
| zinc ion binding | POLR2L;RABGGTA;SIRT2;TGFB1I1;NR2F6;NSMCE1;RASSF1;TRIM35-28;NR5A1A |
KDM4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM4A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM4A.
HIST2H4B; HIST1H3D; HIST3H3
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