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KDM4C

  • Official Full Name

    lysine (K)-specific demethylase 4C

  • Overview

    This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
  • Synonyms

    KDM4C; lysine (K)-specific demethylase 4C; GASC1; JHDM3C; JMJD2C; TDRD14C; bA146B14.1; lysine-specific demethylase 4C; GASC-1 protein; tudor domain containing 14C; jumonji domain containing 2C; jumonji domain-containing protein 2C; gene amplified in squamous cell carcinoma 1 protein; JmjC domain-containing histone demethylation protein 3C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KDM4C-51H Active Recombinant Human KDM4C, FLAG-tagged Sf9 Insect Cell Flag
Human KDM4C-428H Recombinant Human Lysine (K)-specific Demethylase 4C, GST-tagged Sf9 Insect Cell GST
Human KDM4C-757H Recombinant Human KDM4C Mammalian Cell His
Human KDM4C-203H Recombinant Human KDM4C, GST-tagged Sf9 Insect Cell GST
Human KDM4C-4994HCL Recombinant Human KDM4C 293 Cell Lysate HEK293 N/A
Human KDM4C-3199H Recombinant Human KDM4C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KDM4C-031H Recombinant Human KDM4C Protein, GST-tagged E. coli GST
Human KDM4C-575H Recombinant Human KDM4C Protein, His-tagged E.coli His Leu685~Lys871
Human KDM4C-0530H Recombinant Human KDM4C Protein (M1-K347), His tagged E.coli His M1-K347
Human KDM4C-011H Recombinant Human KDM4C Protein, GST-tagged E.coli GST
Human KDM4C-3199H-B Recombinant Human KDM4C Protein Pre-coupled Magnetic Beads HEK293
Human KDM4C-0529H Recombinant Human KDM4C Protein (M1-K347), Tag Free E.coli No tag M1-K347
Mouse KDM4C-8592M Recombinant Mouse KDM4C Protein Mammalian Cell His
Mouse Kdm4c-3682M Recombinant Mouse Kdm4c Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse KDM4C-4780M Recombinant Mouse KDM4C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KDM4C-4780M-B Recombinant Mouse KDM4C Protein Pre-coupled Magnetic Beads HEK293
Zebrafish KDM4C-5463Z Recombinant Zebrafish KDM4C Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KDM4C Related Articles
  • KDM4C Related Research Area

KDM4C involved in several pathways and played different roles in them. We selected most pathways KDM4C participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3, Chromatin modifying enzymes, Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM4C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3HIST2H3C;HIST3H2BB;KDM4C;NCOA2;HIST4H4;KDM1A
Chromatin modifying enzymesKDM6B;WDR77;BRPF1;KAT6B;ACTL6B;MSL2;SMARCD1;SAP30;SAP30L
Chromatin organizationC3orf75;PBRM1L;PHF17;CARM1;ACTL6B;KIAA1267;KDM1B;SAP30L;MSL2
Coregulation of Androgen receptor activityPIAS3;CMTM2A;CMTM2;PATZ1;CARM1;ZMIZ1;KDM3A;KDM1A;CTDSP1
HDMs demethylate histonesKDM5D;KDM4C;KDM1B;KDM2AA;KDM4A;KDM6B;PHF8;KDM5A;KDM3B
RHO GTPase EffectorsNCKAP1;NCKIPSD;EVL;SPC25;WASF3;SGOL2;AHCTF1;FMNL2;KDM4C
RHO GTPases activate PKNs
Signal TransductionEMR2;NET1;ARHGAP8;CSHL1;ARHGAP9;ALDH8A1;TMED5;ROPN1;SOX4A

KDM4C has several biochemical functions, for example, androgen receptor binding, dioxygenase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM4C itself. We selected most functions KDM4C had, and list some proteins which have the same functions with KDM4C. You can find most of the proteins on our site.

Function Related Protein
androgen receptor bindingAr;PKN1;NCOA4;PRKCB;SMARCA4;KDM4C;PRPF6;CTNNB1;RNF14
dioxygenase activityKDM4C;ASPHD2;KDM3A;ALKBH6;TDO2B;ALOX12E;P4HA1B;ALOX5B.3;KDM3B
enzyme bindingEGLN1;CCND1;PPP3CB;CYP2A4;UGT1A6B;TARBP2;TSPAN5;IL6R;IQCB1
histone demethylase activityKDM2B;KDM4C;PHF8;KDM1A
histone demethylase activity (H3-K9 specific)KDM7AB;KDM1A;PHF2;JHDM1D;PHF8;KDM4C;KDM4D
zinc ion bindingSRSF7B;ZFML;RNF150A;RAG2;PHC1;MMP3;MKRN4;ADH1;ANKIB1

KDM4C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM4C here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM4C.

CBX4; rbl1_human_gene; orc1_human_gene; cdc6_human_gene; msh2_human_gene; dpola_human_gene; ccne1_human_gene; mcm3_human_gene; pcna_human_gene; ccnb1_human_gene; mpip1_human_gene; dyr_human_gene

Guo, XQ; Tian, ZT; et al. Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2 alpha. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47:106-113(2015).
Chin, YW; Han, SY; et al. KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review. EXPERT OPINION ON THERAPEUTIC PATENTS 25:135-144(2015).
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