KDM5A
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Official Full Name
lysine (K)-specific demethylase 5A
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Overview
Lysine-specific demethylase 5A is an enzyme that in humans is encoded by the KDM5A gene.<br/>The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. It was formally known as Retinoblastoma Binding Protein 2 (RBP2). This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<br/>The Drosophila homolog, LID, was found to be an H3K4 histone demethylase that binds to c-Myc. It was recently renamed to Lysine Demethylase 5A (KDM5A).<br/>Enzymatically can be designated as a trimethyllysine dioxygenase. -
Synonyms
RBP2; RBBP2; RBBP-2; JARID1A; lysine-specific demethylase 5A; OTTHUMP00000237742; histone demethylase JARID1A; retinoblastoma binding protein 2; retinoblastoma-binding protein 2; jumonji/ARID domain-containing protein 1A; Jumonji, AT rich interactive domain 1A (RBP2-like); Jumonji, AT rich interactive domain 1A (RBBP2-like); KDM5A; lysine (K)-specific demethylase 5A;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- DDK
- Flag
- His
- His (Fc)
- Avi
- His|SUMO
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | KDM5A-43H | Active Recombinant Human KDM5A, FLAG-tagged | Sf9 Insect Cell | Flag |
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| Human | KDM5A-29894TH | Recombinant Human KDM5A | Wheat Germ | N/A | 100 amino acids |
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| Human | KDM5A-683H | Recombinant Human KDM5A Protein, DDK-tagged | HEK293 | DDK |
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| Human | KDM5A-597H | Recombinant Human KDM5A Protein (437-603 aa), His-SUMO-tagged | E.coli | His/SUMO | 437-603 aa |
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| Human | KDM5A-1432H | Recombinant Human KDM5A Protein (437-603 aa), His-tagged | Yeast | His | 437-603 aa |
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| Mouse | KDM5A-8594M | Recombinant Mouse KDM5A Protein | Mammalian Cell | His |
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| Mouse | KDM5A-4782M | Recombinant Mouse KDM5A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | KDM5A-4782M-B | Recombinant Mouse KDM5A Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
KDM5A involved in several pathways and played different roles in them. We selected most pathways KDM5A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | MSL3;KAT7B;MBD3;SMYD3;HMG20B;MTA1;SMARCC2;ING5A;MBD3B |
| Chromatin organization | SMARCB1A;KDM5C;ATXN7L3;PRMT5;ING3;TADA3;MORF4L1;SMARCC2;KDM5D |
| HDMs demethylate histones | KDM7AB;KDM5BB;JHDM1D;PHF8;KDM5BA;KDM4C;KDM2AA;PHF2;KDM5D |
KDM5A has several biochemical functions, for example, DNA binding, chromatin binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM5A itself. We selected most functions KDM5A had, and list some proteins which have the same functions with KDM5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HNF1A;FOXQ2;CBFB;ARID1A;FOXI3B;PHOX2BB;NR5A5;ANKRD1;C5orf20 |
| chromatin binding | PPARG;BAHCC1;DLX3;YAP1;SP140;NKAP;HIST2H3C1;RERE;ATAD2 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | ALKBH5;KDM5B;P4HTM;ALKBH4;KDM5BA;KDM5BB;C14orf169;JHDM1D;KDM5A |
| protein binding | CSF3R;SSNA1;C1orf21;DCLRE1B;SLC22A7;ALKBH4;SKA3;IGFBP7;HSD17B8 |
| transcription coactivator activity | KDM5A;USP22;KMT2E;CALCOCO1;TAF5L;HCFC1;SUB1;GATA3;NFE2L3 |
| transcription factor activity, sequence-specific DNA binding | FOXP3A;ZNF573;ARNT2;RUNX1;ELK1;HOMEZA;HOXA2B;ZNF83;TEAD4 |
| zinc ion binding | NR3C2;ADAM21;RNF34B;GCM1;LMX1A;ZDHHC23;GATAD2AB;MUL1B;NR1H2 |
KDM5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM5A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM5A.
CCT6A; h3_peptide_2-18; SIN3B; HDAC1; GATAD1; TM9SF4; PHF12; Rbm8a
- Q&As
- Reviews
Q&As (5)
Ask a questionGiven its role in cancer and developmental disorders, KDM5A protein may hold promise as a target for personalized medicine approaches, particularly in the context of precision oncology.
Yes, several small molecule inhibitors targeting KDM5A protein are under investigation for their potential as anti-cancer agents.
KDM5A protein is known to interact with various cellular pathways, including those involved in chromatin remodeling, cell cycle regulation, and DNA damage response.
KDM5A protein is known to regulate the expression of genes crucial for normal development, and mutations in the KDM5A gene have been associated with developmental disorders such as intellectual disability and autism spectrum disorders.
Techniques such as immunohistochemistry and western blotting are commonly used to measure KDM5A protein levels in clinical samples.
Customer Reviews (3)
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The KDM5A Protein offers a wide range of applications, making it highly versatile for various experimental settings.
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