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KDM6A

Official Full Name

lysine (K)-specific demethylase 6A
Overview

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Synonyms

KDM6A; lysine (K)-specific demethylase 6A; UTX; KABUK2; bA386N14.2; lysine-specific demethylase 6A; histone demethylase UTX; ubiquitously-transcribed TPR gene on the X chromosome; ubiquitously-transcribed TPR protein on the X chromosome; ubiquitously transcribed tetratricopeptide repeat protein X-linked; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX));

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	KDM6A-84H	Active Recombinant Human KDM6A protein, FLAG-tagged	Insect Cell	Flag	Inquiry
Human	KDM6A-4991HCL	Recombinant Human KDM6A 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	Kdm6a-3683M	Recombinant Mouse Kdm6a Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry

Involved Pathway
Protein Function
Interacting Protein
KDM6A Related Articles
KDM6A Related Research Area

KDM6A involved in several pathways and played different roles in them. We selected most pathways KDM6A participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Transcriptional misregulation in cancer	ASPSCR1;HOXA9;LRP2BP;HOXA10;PRCC;HDAC2;FUS;MEIS1;RXRB

KDM6A has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, dioxygenase activity, histone demethylase activity (H3-K27 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by KDM6A itself. We selected most functions KDM6A had, and list some proteins which have the same functions with KDM6A. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	TCF3A;BSX;ZNF680;TBX3;NPAS4;ZNF92;GABPA;DPF2;ZNF217
dioxygenase activity	PHYHD1;PLOD1A;KDM4B;ASPHD2;HPDB;P4HA1B;TDO2A;KDM6B;ADOA
histone demethylase activity (H3-K27 specific)	PHF8;KDM6B;KDM6BB;KDM7AB;JHDM1D;KDM6A
identical protein binding	KRTAP10-5;MCIN;DDX58;IIGP1;NEFL;SDF4;TGFB3;NFKBIA;MYD88
metal ion binding	KLF6;ZNF274;ZNF548;DNAJA3;MMP13A;MOCS3;ASPHD2;NPAS2;MBNL1

KDM6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM6A here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM6A.

ASH2L; SIX4; SMAD9; KMT2D; MATR3; WDR5; NCOA6; RBBP5

Nickerson, ML; Dancik, GM; et al. Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer. CLINICAL CANCER RESEARCH 20:4935-4948(2014).

Tunovic, S; Barkovich, J; et al. De novo ANKRD11 and KDM1A gene mutations in a male with features of KBG syndrome and Kabuki syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164:1744-1749(2014).

Histone Demethylases