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KEL

Official Full Name

Kell blood group
Overview

This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains s
Synonyms

KEL; Kell blood group; kell blood group glycoprotein homolog; CD238; CD238 antigen; ECE3; Kell blood group glycoprotein; Kell blood group metallo endopeptidase; Kell blood group metalloendopeptidase; KELL NULL; Kell protein; KELL_HUMAN; OTTMUSP00000032452; Kel blood group protein; Kell blood group, metallo-endopeptidase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Mouse
Rat

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Insect cells
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

C
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KEL-26282TH	Recombinant Human KEL	Wheat Germ	N/A	732 amino acids	Inquiry
Human	KEL-1836H	Recombinant Human KEL protein, His & T7-tagged	E.coli	His/T7	Arg128~Ser332 (Accession # P23276)	Inquiry
Human	KEL-4990HCL	Recombinant Human KEL 293 Cell Lysate	HEK293	N/A		Inquiry
Human	KEL-262HF	Recombinant Full Length Human KEL Protein	In Vitro Cell Free System		732 amino acids	Inquiry
Human	KEL-1228H	Recombinant Human KEL Protein (Asn68-Ser280), N-His tagged	E.coli	N-His	Asn68-Ser280	Inquiry
Human	KEL-079H	Recombinant Human KEL Protein, His-tagged	E.coli	His		Inquiry
Human	KEL-4334H	Recombinant Human KEL Protein (Asn68-Trp732), C-His tagged	Mammalian cells	C-His	Asn68-Trp732	Inquiry
Mouse	Kel-1976M	Active Recombinant Mouse Kell Blood Group, His-tagged	Mammalian cells	His		Inquiry
Mouse	Kel-1837M	Recombinant Mouse Kel protein, His & T7-tagged	E.coli	His/T7	Ile49~Leu358 (Accession # Q9EQF2)	Inquiry
Mouse	KEL-8604M	Recombinant Mouse KEL Protein	Mammalian Cell	His		Inquiry
Mouse	Kel-4791M	Recombinant Mouse Kel Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Kel-018M	Recombinant Mouse Kel Protein, His-tagged	Insect cells	His		Inquiry
Mouse	Kel-4791M-B	Recombinant Mouse Kel Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Kel-1838R	Recombinant Rat Kel protein, His & T7-tagged	E.coli	His/T7	Ser439~Trp713 (Accession # F1M761)	Inquiry
Homo sapiens (Human)	RFL28365HF	Recombinant Full Length Human Kell Blood Group Glycoprotein(Kel) Protein, His-Tagged	E.coli expression system	His	Full Length (1-732)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
KEL Related Articles
KEL Related Research Area

KEL involved in several pathways and played different roles in them. We selected most pathways KEL participated on our site, such as Class A/1 (Rhodopsin-like receptors), GPCR ligand binding, Peptide ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with KEL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)	GPR4;ADRA2B;ADRB1;EDNRA;INSL5;GPR31B;TAC3;POMCB;NPSR1
GPCR ligand binding	AGTR2;LPAR2A;CCR9;GHRH;GPR120;ADM2A;RAMP1;RXFP2;AGT
Peptide ligand-binding receptors	APLNR;TAC1;CCL35.1;PNOC;QRFP;PROK1;CCL19A.2;UTS2D;RXFP2
Signal Transduction	GPR132B;ARHGAP31;ZNRF3;NCKIPSD;ARHGAP15;GAL;GPR37B;METAP1;CCK
Signaling by GPCR	CRHB;OPN4A;GPRC6A;OR52J3;OPN4B;OXGR1A.3;RGS4;RGS12;TAS2R7

KEL has several biochemical functions, for example, metal ion binding, metalloendopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KEL itself. We selected most functions KEL had, and list some proteins which have the same functions with KEL. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	MAT2AA;COL1A2;NUDT10;NINL;SHRPRBCK1R;PLAG1;PGCP;TYRP1B;ZBBX
metalloendopeptidase activity	PAPLN;YME1L1;MMP11;ADAMTS15A;MMP14;ADAM33;MMP13A;MEP1A.2;PAPPAB
protein binding	PMM2;LSM10;SMOC1;PYCARD;PSIP1;PVR;RDM1;CHMP1B;WTAP

KEL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KEL here. Most of them are supplied by our site. Hope this information will be useful for your research of KEL.

EWSR1; TUBA1A

Boturao-Neto, E; Yamamoto, M; et al. Molecular Basis of KELnull Phenotype in Brazilians. TRANSFUSION MEDICINE AND HEMOTHERAPY 42:52-58(2015).

Meyer, S; Vollmert, C; et al. High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. TRANSFUSION 54:3198-3207(2014).

Metalloproteases and Regulators